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公开(公告)号：US5300687A
公开(公告)日：1994-04-05
申请号：US732267
申请日：1991-07-18
申请人： Charles Schwender , Keith Demarest , David Wustrow
发明人： Charles Schwender , Keith Demarest , David Wustrow
IPC分类号： A61K31/66 , A61P3/00 , C07F9/38 , C07F9/40 , C07F9/6533 , C07F9/02 , C07D265/30 , C07D279/12 , C07F9/28
CPC分类号： C07F9/6533 , C07F9/3882 , C07F9/4056
摘要： Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.
摘要翻译： 公开了通式I的新型苄基膦酸盐化合物：（*化学结构*）I可用于治疗哺乳动物骨形成和骨量增加中包括绝经后骨质疏松症的骨消耗疾病。
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公开(公告)号：US20090318332A1
公开(公告)日：2009-12-24
申请号：US12549426
申请日：2009-08-28
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
CPC分类号： C07C59/68 , C07C323/20
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译： 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号：US20070197590A1
公开(公告)日：2007-08-23
申请号：US11669284
申请日：2007-01-31
申请人： Duane DeMong , Mingde Xia , Scott Pollack , Xiaoping Zheng , James Brackley , Michael Wachter , Druie Cavender , Keith Demarest
发明人： Duane DeMong , Mingde Xia , Scott Pollack , Xiaoping Zheng , James Brackley , Michael Wachter , Druie Cavender , Keith Demarest
IPC分类号： A61K31/4545 , C07D401/14
CPC分类号： C07D401/14 , C07D211/26 , C07D211/48 , C07D405/14 , C07D471/04
摘要： Substituted dipiperidine compounds of Formula (I) or a form thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
摘要翻译： 式（I）的取代二哌啶化合物或其形式，其是CCR2拮抗剂，并且可用于预防，治疗或改善有需要的受试者中CCR2介导的炎性综合征，病症或疾病。
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公开(公告)号：US20060058382A1
公开(公告)日：2006-03-16
申请号：US11226645
申请日：2005-09-14
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号： A61K31/277 , A61K31/192 , A61K31/195 , C07C255/40 , C07C59/64
CPC分类号： C07C59/68 , C07C323/20
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
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公开(公告)号：US20050239782A1
公开(公告)日：2005-10-27
申请号：US11148114
申请日：2005-06-08
申请人： Geoffrey Heintzelman , Kristin Averill , John Dodd , Keith Demarest , Yuting Tang , Paul Jackson
发明人： Geoffrey Heintzelman , Kristin Averill , John Dodd , Keith Demarest , Yuting Tang , Paul Jackson
IPC分类号： A61K31/496 , A61K31/5377 , C07D221/16 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D413/02 , C07D491/04 , C07D43/02
CPC分类号： A61K31/473 , C07D221/16 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , C07D491/04
摘要： This invention provides novel arylindenopyridines of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing Adensine A2a receptors or reducing PDE activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
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公开(公告)号：US07875744B2
公开(公告)日：2011-01-25
申请号：US12549426
申请日：2009-08-28
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号： C07C59/00 , C07C53/135 , C07C255/00 , A61K31/275 , A61K31/20 , A61K31/195
CPC分类号： C07C59/68 , C07C323/20
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译： 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号：US07425649B2
公开(公告)日：2008-09-16
申请号：US11226645
申请日：2005-09-14
申请人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
发明人： Gee-Hong Kuo , Rui Zhang , Aihua Wang , Alan DeAngelis , Keith Demarest , Patricia Pelton
IPC分类号： C07C59/00 , C07C53/134 , C07C255/00 , A61K31/275 , A61K31/20 , A61K31/195
CPC分类号： C07C59/68 , C07C323/20
摘要： The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.
摘要翻译： 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。
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公开(公告)号：US20070213386A1
公开(公告)日：2007-09-13
申请号：US11800878
申请日：2007-05-08
申请人： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
发明人： Han-Cheng Zhang , Bruce Maryanoff , David McComsey , Kimberly White , Hong Ye , Leonard Hecker , Bruce Conway , Keith Demarest
IPC分类号： A61K31/40 , A61K31/415 , C07D209/02 , C07D221/00 , C07D231/56 , C07D239/02 , C07D401/02
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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公开(公告)号：US07232906B2
公开(公告)日：2007-06-19
申请号：US10454561
申请日：2003-06-04
申请人： Han Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
发明人： Han Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly White , Hong Ye , Leonard R. Hecker , Bruce Conway , Keith Demarest
IPC分类号： C07D239/24 , C07D209/02
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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公开(公告)号：US20060205762A1
公开(公告)日：2006-09-14
申请号：US11435999
申请日：2006-05-17
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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