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公开(公告)号:US08088815B2
公开(公告)日:2012-01-03
申请号:US12939234
申请日:2010-11-04
申请人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Bradford James Graves , Nan Jiang , Jing Zhang , Zhuming Zhang
发明人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Bradford James Graves , Nan Jiang , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/4015 , C07D487/10
CPC分类号: C07D487/10
摘要: There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物其中X,Y和R 1至R 8与本文所述的对映异构体,其药学上可接受的盐和酯一起描述。 这些化合物可用作抗癌剂。
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公开(公告)号:US20110118283A1
公开(公告)日:2011-05-19
申请号:US12898955
申请日:2010-10-06
申请人: Qingjie Ding , Nan Jiang , Jin-Jun Liu , Jing Zhang , Zhuming Zhang
发明人: Qingjie Ding , Nan Jiang , Jin-Jun Liu , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/506 , C07D409/14 , C07D409/04 , C07D401/14 , C07D401/04 , C07D405/14 , C07D403/04 , A61K31/4025 , A61K31/4439 , A61P35/00
CPC分类号: C07D403/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/04 , C07D409/14
摘要: There are provided compounds of the formula wherein R1, R2, R3, R3, R4, R5 are as described herein and enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物其中R 1,R 2,R 3,R 3,R 4,R 5如本文所述,其对映异构体,药学上可接受的盐和酯。 这些化合物可用作抗癌剂。
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公开(公告)号:US20100075948A1
公开(公告)日:2010-03-25
申请号:US12556656
申请日:2009-09-10
申请人: Qingjie Ding , Nan Jiang , Jin-Jun Liu , Tina Morgan Ross , Jing Zhang , Zhuming Zhang
发明人: Qingjie Ding , Nan Jiang , Jin-Jun Liu , Tina Morgan Ross , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/4025 , C07D207/00 , A61K31/40 , A61K31/44 , C07D401/12 , C07D403/06 , A61K31/497 , C07D413/14 , A61K31/5377
CPC分类号: C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/107
摘要: There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, R5, R6 and R7 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物其中X,Y,R 1,R 2,R 3,R 3,R 4,R 5,R 6和R 7如本文所述,其对映异构体及其药学上可接受的盐和酯。 这些化合物可用作抗癌剂。
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公开(公告)号:US08134001B2
公开(公告)日:2012-03-13
申请号:US12272870
申请日:2008-11-18
申请人: Qingjie Ding , Nan Jiang , Song Yang , Jing Zhang , Zhuming Zhang
发明人: Qingjie Ding , Nan Jiang , Song Yang , Jing Zhang , Zhuming Zhang
IPC分类号: C07D471/10 , A61K31/44
CPC分类号: C07D471/10
摘要: There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R′ are as described herein. The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物及其药学上可接受的盐和酯,其中W,V,X,Y,A,R和R'如本文所述。 这些化合物可用作抗癌剂。
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公开(公告)号:US20090156610A1
公开(公告)日:2009-06-18
申请号:US12272870
申请日:2008-11-18
申请人: Qingjie Ding , Nan Jiang , Song Yang , Jing Zhang , Zhuming Zhang
发明人: Qingjie Ding , Nan Jiang , Song Yang , Jing Zhang , Zhuming Zhang
IPC分类号: A61K31/438 , C07D471/10 , A61K31/496 , A61K31/497 , A61P35/00
CPC分类号: C07D471/10
摘要: There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereofwherein W, V, X, Y, A, R and R′ are as described herein.The compounds are useful as anticancer agents.
摘要翻译: 提供下式的化合物及其药学上可接受的盐和酯,其中W,V,X,Y,A,R和R'如本文所述。 这些化合物可用作抗癌剂。
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公开(公告)号:US07615634B2
公开(公告)日:2009-11-10
申请号:US11471001
申请日:2006-06-20
申请人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Nan Jiang , Allen John Lovey , John Anthony Moliterni , John Guilfoyle Mullin, Jr. , Binh Thanh Vu , Peter Michael Wovkulich
发明人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Nan Jiang , Allen John Lovey , John Anthony Moliterni , John Guilfoyle Mullin, Jr. , Binh Thanh Vu , Peter Michael Wovkulich
IPC分类号: C07D239/47 , C07D239/48
CPC分类号: C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14
摘要: Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.
摘要翻译: 公开了新的中间体化合物。 这些化合物可用于合成抑制细胞周期蛋白依赖性激酶,特别是细胞周期蛋白依赖性激酶4(Cdk4)的4-氨基嘧啶-5-酮衍生物。 4-氨基嘧啶-5-酮衍生物及其药学上可接受的盐具有抗增殖活性,并且可用于治疗或控制癌症,特别是实体瘤。
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公开(公告)号:US06818663B2
公开(公告)日:2004-11-16
申请号:US10429551
申请日:2003-05-05
申请人: Xin-Jie Chu , Qingjie Ding , Nan Jiang , Kyungjin Kim , Allen John Lovey , Warren William McComas , John Guifoyle Mullin, Jr. , Jefferson Wright Tilley
发明人: Xin-Jie Chu , Qingjie Ding , Nan Jiang , Kyungjin Kim , Allen John Lovey , Warren William McComas , John Guifoyle Mullin, Jr. , Jefferson Wright Tilley
IPC分类号: C07D27742
CPC分类号: C07D417/06 , C07D277/42 , C07D417/12 , C07D417/14
摘要: The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung and colon and prostate tumors.
摘要翻译: 本发明涉及新型式的二氨基噻唑,这些化合物抑制细胞周期蛋白依赖性激酶4(Cdk4),并且对Cdk2和Cdk1具有选择性。 这些化合物及其药学上可接受的盐和酯具有抗增殖活性,并且可用于治疗或控制癌症,特别是实体瘤。 本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法,特别是乳腺癌,肺癌和结肠癌和前列腺肿瘤的治疗或控制。
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公开(公告)号:US07157455B2
公开(公告)日:2007-01-02
申请号:US10770379
申请日:2004-02-02
申请人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Nan Jiang , Allen John Lovey , John Anthony Moliterni , John Guilfoyle Mullin, Jr. , Binh Thanh Vu , Peter Michael Wovkulich
发明人: David Joseph Bartkovitz , Xin-Jie Chu , Qingjie Ding , Nan Jiang , Allen John Lovey , John Anthony Moliterni , John Guilfoyle Mullin, Jr. , Binh Thanh Vu , Peter Michael Wovkulich
IPC分类号: C07D401/12 , C07D403/12 , C07D413/12 , A61K31/4468 , C07D239/42
CPC分类号: C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14
摘要: Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 4-aminopyrimidine-5-one derivatives.
摘要翻译: 公开了新的4-氨基嘧啶-5-酮衍生物。 这些化合物抑制细胞周期蛋白依赖性激酶,特别是细胞周期蛋白依赖性激酶4(Cdk4)。 这些化合物及其药学上可接受的盐和酯具有抗增殖活性,并且可用于治疗或控制癌症,特别是实体瘤。 本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法,特别是乳腺癌,肺癌,结肠癌和前列腺肿瘤的治疗或控制。 还公开了可用于制备这些新型4-氨基嘧啶-5-酮衍生物的中间体。
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公开(公告)号:US20080188506A1
公开(公告)日:2008-08-07
申请号:US12023142
申请日:2008-01-31
申请人: Qingjie Ding , Jin-Jun Liu , Zhuming Zhang
发明人: Qingjie Ding , Jin-Jun Liu , Zhuming Zhang
IPC分类号: A61K31/438 , C07D471/10 , C07D471/20
CPC分类号: C07D471/10 , C07D471/20
摘要: There are provided spiroindolinones of the formula and enantiomers and pharmaceutically acceptable salts and esters thereof which have utility as antiproliferative agents, especially, as anticancer agents.
摘要翻译: 提供具有式和对映异构体的螺二吲哚啉酮及其药学上可接受的盐和酯,其可用作抗增殖剂,特别是作为抗癌剂。
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公开(公告)号:US20080009486A1
公开(公告)日:2008-01-10
申请号:US11846597
申请日:2007-08-29
申请人: Li Chen , Qingjie Ding , Jin-Jun Liu , Song Yang , Zhuming Zhang
发明人: Li Chen , Qingjie Ding , Jin-Jun Liu , Song Yang , Zhuming Zhang
IPC分类号: A61K31/438 , A61K31/5377 , A61K31/541 , A61P35/00 , C07D221/20 , C07D273/01 , C07D279/12
CPC分类号: C07D471/10
摘要: The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described. The compounds have utility as antiproliferative agents, especially, as anticancer agents.
摘要翻译: 本发明涉及下式的螺二吲哚啉酮衍生物及其对映体及其药学上可接受的盐和酯,其中R 1,R 2,R 3, R 4,R 5,R 6,R 7和R 8, ,如本文所述。 这些化合物具有抗增生剂的作用,特别是作为抗癌剂。
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