公开(公告)号：US06440663B1

公开(公告)日：2002-08-27

申请号：US09166350

申请日：1998-10-05

申请人： Matthew J. Scanlan ,  Elisabeth Stockert ,  Yao-Tseng Chen ,  Lloyd J. Old ,  Elke Jager ,  Alex Knuth

发明人： Matthew J. Scanlan ,  Elisabeth Stockert ,  Yao-Tseng Chen ,  Lloyd J. Old ,  Elke Jager ,  Alex Knuth

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K35/00 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/11 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492

摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in renal cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with renal cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

摘要翻译： 已经通过使用来自癌症患者的抗血清的肾癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。 本发明涉及在患有肾癌的患者中表达的癌症相关抗原的核酸和编码多肽。 本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。 本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。 还提供了前述的片段，包括功能片段和变体。 另外提供了含有上述分子的试剂盒。 本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

公开(公告)号：US06291658B1

公开(公告)日：2001-09-18

申请号：US08851138

申请日：1997-05-05

申请人： Ali O. Gure ,  Ozlem Tureci ,  Ugur Sahin ,  Solam Tsang ,  Matthew J. Scanlan ,  Alexander Knuth ,  Michael Pfreundschuh ,  Lloyd J. Old ,  Yao-Tseng Chen

发明人： Ali O. Gure ,  Ozlem Tureci ,  Ugur Sahin ,  Solam Tsang ,  Matthew J. Scanlan ,  Alexander Knuth ,  Michael Pfreundschuh ,  Lloyd J. Old ,  Yao-Tseng Chen

IPC分类号： C07H2102

CPC分类号： C07K14/47

摘要： The invention relates to members of the SSX family of genes, as well as their uses.

摘要翻译： 本发明涉及SSX家族基因的成员及其用途

公开(公告)号：US06982316B1

公开(公告)日：2006-01-03

申请号：US09502945

申请日：2000-02-11

申请人： Matthew J. Scanlan ,  Yao-Tseng Chen ,  Elisabeth Stockert ,  Lloyd J. Old

发明人： Matthew J. Scanlan ,  Yao-Tseng Chen ,  Elisabeth Stockert ,  Lloyd J. Old

IPC分类号： C07K14/47 ,  C07K7/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C12Q1/6886 ,  G01N33/56977 ,  G01N33/5748

摘要： Various molecules associated with disorders such as cancer are disclosed. The invention also discloses diagnostic aid therapeutic methods based upon these molecules, as well as compositions for stimulating an immune response and methods for identifying cancer-associated nucleic acid and polypeptide molecules.

摘要翻译： 公开了与疾病如癌症相关的各种分子。 本发明还公开了基于这些分子的诊断辅助治疗方法，以及用于刺激免疫应答的组合物和用于鉴定癌症相关核酸和多肽分子的方法。

公开(公告)号：US06794501B2

公开(公告)日：2004-09-21

申请号：US09849602

申请日：2001-05-04

申请人： Yao-Tseng Chen ,  Lloyd J. Old ,  Matthew J. Scanlan ,  Elisabeth Stockert

发明人： Yao-Tseng Chen ,  Lloyd J. Old ,  Matthew J. Scanlan ,  Elisabeth Stockert

IPC分类号： C07H2104

CPC分类号： G01N33/57419 ,  A61K38/00 ,  C07K14/4748 ,  C07K16/3046 ,  C12Q1/6886 ,  C12Q2600/156

摘要： The invention provides methods for diagnosing cancer including colon cancer, based on the identification of certain colon cancer-associated polypeptides as antigens that elicit immune responses in colon cancer. The identified antigens can be utilized as markers for diagnosing colon cancer, and for following the course of treatment of colon cancer.

摘要翻译： 本发明基于鉴定某些结肠癌相关多肽作为在结肠癌中引起免疫应答的抗原，提供诊断包括结肠癌的癌症的方法。 所鉴定的抗原可用作诊断结肠癌的标志物，以及用于治疗结肠癌的过程。

公开(公告)号：US06686147B1

公开(公告)日：2004-02-03

申请号：US09392714

申请日：1999-09-09

申请人： Matthew J. Scanlan ,  Ali Gure ,  Lloyd J. Old ,  Yao-Tseng Chen ,  Barbara Williamson

发明人： Matthew J. Scanlan ,  Ali Gure ,  Lloyd J. Old ,  Yao-Tseng Chen ,  Barbara Williamson

IPC分类号： C12Q168

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in testis cells using antisera from seminoma patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with a variety of cancers. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

摘要翻译： 已经通过使用来自精原细胞瘤患者的抗血清的睾丸细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。 本发明涉及在患有多种癌症的患者中表达的癌症相关抗原的核酸和编码多肽。 本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。 本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。 还提供了前述的片段，包括功能片段和变体。 另外提供了含有上述分子的试剂盒。 本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

公开(公告)号：US06517837B1

公开(公告)日：2003-02-11

申请号：US09510543

申请日：2000-02-22

申请人： Matthew J. Scanlan ,  Yao-Tseng Chen ,  Elisabeth Stockert ,  Lloyd J. Old

发明人： Matthew J. Scanlan ,  Yao-Tseng Chen ,  Elisabeth Stockert ,  Lloyd J. Old

IPC分类号： A61K3900

CPC分类号： G01N33/56977 ,  A61K38/00 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/5748

摘要： Various molecules associated with disorders such as cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules, as well as compositions for stimulating an immune response and methods for identifying cancer-associated nucleic acid and polypeptide molecules.

摘要翻译： 公开了与疾病如癌症相关的各种分子。 本发明还公开了基于这些分子的诊断和治疗方法，以及用于刺激免疫应答的组合物和用于鉴定癌症相关核酸和多肽分子的方法。

公开(公告)号：US07560537B2

公开(公告)日：2009-07-14

申请号：US10260708

申请日：2002-09-30

申请人： Matthew J. Scanlan ,  Sang-Yull Lee ,  Lloyd J. Old

发明人： Matthew J. Scanlan ,  Sang-Yull Lee ,  Lloyd J. Old

IPC分类号： C07H21/02

CPC分类号： C07K14/4748 ,  C07H21/04 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  G01N33/57488

摘要： The invention relates to sarcoma-associated antigens and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments thereof associated with sarcoma in methods and compositions for the diagnosis and treatment of diseases, such as cancer. More specifically, the invention relates to the discovery of a novel cancer/testis (CT) antigen, NY-SAR-35.

摘要翻译： 本发明涉及肉瘤相关抗原和编码它们的核酸分子。 本发明进一步涉及与肉瘤相关的核酸分子，多肽及其片段在用于诊断和治疗诸如癌症的疾病的方法和组合物中的用途。 更具体地，本发明涉及新型癌/睾丸（CT）抗原NY-SAR-35的发现。

公开(公告)号：US5587299A

公开(公告)日：1996-12-24

申请号：US230491

申请日：1994-04-20

申请人： Wolfgang J. Rettig ,  Matthew J. Scanlan ,  Pilar Garin-Chesa ,  Lloyd J. Old

发明人： Wolfgang J. Rettig ,  Matthew J. Scanlan ,  Pilar Garin-Chesa ,  Lloyd J. Old

IPC分类号： C12N15/09 ,  C07K14/705 ,  C12N5/00 ,  C12N5/10 ,  C12N9/48 ,  C12N9/64 ,  C12N15/12 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91 ,  C12N15/19

CPC分类号： C12N9/6424 ,  C07K14/705 ,  C07K14/70517 ,  C12N9/48 ,  C12P21/06 ,  C07K2319/00 ,  C12N2799/026

摘要： The invention describes the identification and isolation of nucleic acid molecules which code for fibroblast activation protein alpha, or "FAP.alpha.". Various applications of the isolated molecules are also described.

摘要翻译： 本发明描述了编码成纤维细胞激活蛋白α或“FAPα”的核酸分子的鉴定和分离。 还描述了分离的分子的各种应用。