公开(公告)号：US4115392A

公开(公告)日：1978-09-19

申请号：US734312

申请日：1976-10-20

申请人： Hideo Kato ,  Eiichi Koshinaka ,  Sakae Kurata ,  Ikuo Uesaka

发明人： Hideo Kato ,  Eiichi Koshinaka ,  Sakae Kurata ,  Ikuo Uesaka

IPC分类号： C07D213/80 ,  C07C57/15 ,  C07D213/55

CPC分类号： C07C57/15

摘要： The monofumarate of 3-pyridylmethyl nicotinate and the method of making same. The monofumaric acid addition salt of 3-pyridylmethyl nicotinate is prepared by reacting approximately equimolar amounts of fumaric acid and 3-pyridylmethyl nicotinate.

摘要翻译： 3-吡啶基甲基烟酸的单富马酸及其制备方法。 通过使大约等摩尔量的富马酸和3-吡啶基甲基烟酸酯反应制备烟酸3-吡啶基甲基甲基酮的单富马酸加成盐。

公开(公告)号：US4971990A

公开(公告)日：1990-11-20

申请号：US301354

申请日：1989-01-24

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani ,  Shunichiro Sakurai

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani ,  Shunichiro Sakurai

IPC分类号： C07C311/27 ,  C07D295/26

CPC分类号： C07D295/26 ,  C07C311/27

摘要： Phenoxyethylamine derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.5 represent lower-alkyl, R.sub.2 and R.sub.3, which may be the same or different, each represents hydrogen or lower-alkyl, or ##STR2## represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R.sub.4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha..sub.1 -blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.

公开(公告)号：US4638009A

公开(公告)日：1987-01-20

申请号：US573862

申请日：1984-01-25

申请人： Yasuo Itho ,  Hideo Kato ,  Nobuo Ogawa ,  Kagari Yamagishi ,  Eiichi Koshinaka ,  Hiroyuki Nishino

发明人： Yasuo Itho ,  Hideo Kato ,  Nobuo Ogawa ,  Kagari Yamagishi ,  Eiichi Koshinaka ,  Hiroyuki Nishino

IPC分类号： C07D295/108 ,  A61K31/41 ,  C07D207/06

CPC分类号： C07D295/108

摘要： Certain 4'-alkyl-2-methyl-3-pyrrolidinopropiophenones, acid addition salts thereof, their method of preparation, pharmaceutical compositions embodying the same, and a method of muscle relaxation therewith, are disclosed.

摘要翻译： 公开了某些4'-烷基-2-甲基-3-吡咯烷基苯丙酮，其酸加成盐，其制备方法，含有其的药物组合物及其与肌肉松弛的方法。

公开(公告)号：US4612329A

公开(公告)日：1986-09-16

申请号：US786742

申请日：1985-10-11

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Hiroyuki Nishino ,  Toshihiko Yoshida

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Hiroyuki Nishino ,  Toshihiko Yoshida

IPC分类号： A61K31/275 ,  A61K31/445 ,  C07C20060101 ,  C07C255/58 ,  C07D20060101 ,  C07D211/08 ,  C07D295/08 ,  C07C121/78

CPC分类号： C07C255/00

摘要： Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cartino vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.

摘要翻译： 公开了用于治疗纸浆血管疾病，外周循环功能不全和脑循环衰竭的新型α-氨基烷基-α-烷基苯基乙腈衍生物。

公开(公告)号：US4478838A

公开(公告)日：1984-10-23

申请号：US441635

申请日：1982-11-15

申请人： Yasuo Itho ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Kagari Yamagishi

发明人： Yasuo Itho ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Kagari Yamagishi

IPC分类号： C07D243/08 ,  A61K31/55 ,  A61P9/08 ,  C07D295/18 ,  C07D295/185 ,  A61K31/495 ,  C07D241/04

CPC分类号： C07D295/185 ,  Y10S514/929

摘要： 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives represented by general formula (I): ##STR1## wherein R is a straight- or branched-chain alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 5 to 7 carbon atoms, and pharmaceutically acceptable acid addition salts thereof are disclosed.The 1-(3,4,5-trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives are useful as vasodilator agents.

摘要翻译： 由通式（I）表示的1-（3,4,5-三甲氧基肉桂酰基）-4-氨基羰基乙基取代的哌嗪衍生物：其中R是具有1至6个碳原子的直链或支链烷基或 公开了具有5至7个碳原子的环烷基基团及其药学上可接受的酸加成盐。 1-（3,4,5-三甲氧基肉桂酰基）-4-氨基羰基乙基取代的哌嗪衍生物可用作血管舒张剂。

公开(公告)号：US4166180A

公开(公告)日：1979-08-28

申请号：US795869

申请日：1977-05-11

申请人： Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa

发明人： Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa

IPC分类号： A61K31/495 ,  A61P9/08 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  C07D241/04 ,  C07D317/58 ,  C07D405/04 ,  C07D241/12

CPC分类号： C07D241/04 ,  C07D317/58

摘要： A process is provided for preparing 2-arylpiperazine derivatives and more particularly, 2-phenylpiperazine derivatives of the formula ##STR1## wherein R represents a group selected from the group consisting of a halogen atom, a lower alkyl group (having carbon atoms of 1 to about 8, preferably 1 to 4), a lower alkoxy group (having carbon atoms of 1 to about 8, preferably 1 to 4), a nitro group, a cyano group, a benzyloxy group, a hydroxy group and when n is 2 R is a methylenedioxy group, and n represents 1, 2 or 3.

公开(公告)号：US4792547A

公开(公告)日：1988-12-20

申请号：US941918

申请日：1986-12-15

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  A61K31/55 ,  A61K31/495

CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14

摘要： Novel pyrazine derivatives useful for treatment of bronchial asthma, allergic gastorenteric trouble, hay fever urticaria, allertic rhinitis, and allergic conjunctivitis, and pharmaceutical compositions thereof, are disclosed. The compounds have the formula I as follows: ##STR1## wherein R represents hydrogen or ##STR2## wherein R.sub.1 and R.sub.2 may be the same or different and each independently represents hydrogen, straight or branched-chain lower-alkyl, or cycloalkyl having three to six carbon atoms inclusive, phenyl which may be substituted with halogen, lower-alkyl, or lower-alkoxy, or wherein R.sub.1 and R.sub.2 together represent alkylene of four to six carbon atoms, inclusive, optionally interrupted by one or two nitrogen atoms or one oxygen atom and said ring being optionally substituted by straight or branched-chain lower-alkyl having one to six carbon atoms inclusive, hydroxy, or phenyl,and pharmaceutically-acceptable salts thereof.

摘要翻译： 用于治疗支气管哮喘，过敏性胃炎，花粉荨麻疹，过敏性鼻炎和过敏性结膜炎的新颖吡嗪衍生物及其药物组合物。 化合物具有如下式I：其中R表示氢或者其中R 1和R 2可以相同或不同，并且各自独立地表示氢，直链或支链低级烷基或具有三个至 6个碳原子，可被卤素，低级烷基或低级烷氧基取代的苯基，或其中R 1和R 2一起代表四至六个碳原子的亚烷基，包括任选地被一个或两个氮原子或一个氧 所述环任选被具有1-6个碳原子的直链或支链低级烷基，羟基或苯基取代，及其药学上可接受的盐。

公开(公告)号：US4528287A

公开(公告)日：1985-07-09

申请号：US651423

申请日：1984-09-17

申请人： Yasuo Itoh ,  Hideo Kato ,  Nobuo Ogawa ,  Eiichi Koshinaka ,  Tomio Suzuki ,  Noriyuki Yagi

发明人： Yasuo Itoh ,  Hideo Kato ,  Nobuo Ogawa ,  Eiichi Koshinaka ,  Tomio Suzuki ,  Noriyuki Yagi

IPC分类号： C07D401/02 ,  C07D215/56 ,  A61K31/47 ,  C07D401/04

CPC分类号： C07D215/56

摘要： The invention is concerned with the novel piperazinylquinoline-3-carboxylic acids represented by formula (I) ##STR1## or a pharmacologically-acceptable salt thereof, a process for the preparation of them, and a pharmaceutical composition which contains these new compounds as active ingredient and can be used as the therapeutic agent against bacteria.

摘要翻译： 本发明涉及由式（I）表示的新型哌嗪基喹啉-3-羧酸或其药学上可接受的盐，其制备方法和含有这些新化合物的药物组合物 作为活性成分，可以用作抗细菌的治疗剂。

公开(公告)号：US3936460A

公开(公告)日：1976-02-03

申请号：US531322

申请日：1974-12-10

申请人： Hideo Kato ,  Eiichi Koshinaka

发明人： Hideo Kato ,  Eiichi Koshinaka

IPC分类号： C07D471/10 ,  C07D215/38

CPC分类号： C07D471/10

摘要： Spiro-compounds of the formula: ##SPC1##Are disclosed. These compounds are useful as analgetic, antihistamine and spasmolytic agents. They are indicated in the management of conditions such as headache, seasonal allergies and the like.

摘要翻译： 下式的螺环化合物：

公开(公告)号：US3936459A

公开(公告)日：1976-02-03

申请号：US531452

申请日：1974-12-11

申请人： Hideo Kato ,  Eiichi Koshinaka

发明人： Hideo Kato ,  Eiichi Koshinaka

IPC分类号： C07D471/10 ,  C07D215/38 ,  C07D215/22

CPC分类号： C07D471/10

摘要： Spiro compounds having the structural formula ##SPC1##Where n is an integer of 1 or 2,Are disclosed. These compounds are useful as analgetic, antihistamine and spasmolytic agents. They are indicated in the management of conditions such as headache, seasonal allergies and the like.

摘要翻译： 螺旋化合物具有结构式，其中N为1或2的整数，被披露。 这些化合物可用作止痛药，抗组胺药和解痉药。 它们在诸如头痛，季节性过敏等条件的管理中被指出。