公开(公告)号：US4792547A

公开(公告)日：1988-12-20

申请号：US941918

申请日：1986-12-15

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  A61K31/55 ,  A61K31/495

CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14

摘要： Novel pyrazine derivatives useful for treatment of bronchial asthma, allergic gastorenteric trouble, hay fever urticaria, allertic rhinitis, and allergic conjunctivitis, and pharmaceutical compositions thereof, are disclosed. The compounds have the formula I as follows: ##STR1## wherein R represents hydrogen or ##STR2## wherein R.sub.1 and R.sub.2 may be the same or different and each independently represents hydrogen, straight or branched-chain lower-alkyl, or cycloalkyl having three to six carbon atoms inclusive, phenyl which may be substituted with halogen, lower-alkyl, or lower-alkoxy, or wherein R.sub.1 and R.sub.2 together represent alkylene of four to six carbon atoms, inclusive, optionally interrupted by one or two nitrogen atoms or one oxygen atom and said ring being optionally substituted by straight or branched-chain lower-alkyl having one to six carbon atoms inclusive, hydroxy, or phenyl,and pharmaceutically-acceptable salts thereof.

摘要翻译： 用于治疗支气管哮喘，过敏性胃炎，花粉荨麻疹，过敏性鼻炎和过敏性结膜炎的新颖吡嗪衍生物及其药物组合物。 化合物具有如下式I：其中R表示氢或者其中R 1和R 2可以相同或不同，并且各自独立地表示氢，直链或支链低级烷基或具有三个至 6个碳原子，可被卤素，低级烷基或低级烷氧基取代的苯基，或其中R 1和R 2一起代表四至六个碳原子的亚烷基，包括任选地被一个或两个氮原子或一个氧 所述环任选被具有1-6个碳原子的直链或支链低级烷基，羟基或苯基取代，及其药学上可接受的盐。

公开(公告)号：US4971990A

公开(公告)日：1990-11-20

申请号：US301354

申请日：1989-01-24

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani ,  Shunichiro Sakurai

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Kazuya Mitani ,  Shunichiro Sakurai

IPC分类号： C07C311/27 ,  C07D295/26

CPC分类号： C07D295/26 ,  C07C311/27

摘要： Phenoxyethylamine derivatives represented by the general formula (I): ##STR1## wherein R.sub.1 and R.sub.5 represent lower-alkyl, R.sub.2 and R.sub.3, which may be the same or different, each represents hydrogen or lower-alkyl, or ##STR2## represents a 5- or 6-membered ring system which may include nitrogen, oxygen or sulfur as a ring membered atom, R.sub.4 represents hydrogen or lower-alkyl, and n represents an integer selected from 1 to 3, their optical isomers and pharmacologically-acceptable acid addition salts, which exhibit excellent .alpha..sub.1 -blocking activity, a process for their preparation, pharmaceutical compositions thereof, and a method for the treatment of a subject afflicted with hypertension or dysuria by administrating such a compound, are all disclosed.

公开(公告)号：US4943581A

公开(公告)日：1990-07-24

申请号：US371392

申请日：1989-06-26

申请人： Hiroyoshi Hidaka ,  Toshio Tanaka ,  Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kazuya Mitani ,  Shunichiro Sakurai

发明人： Hiroyoshi Hidaka ,  Toshio Tanaka ,  Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kazuya Mitani ,  Shunichiro Sakurai

IPC分类号： C07D217/02 ,  A61K31/47 ,  A61K31/472 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D217/04

CPC分类号： C07D217/04 ,  Y02P20/55

摘要： An isoquinolinesulfonamide selected from those represented by the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different, and each represent hydrogen or lower-alkyl, and X represents hydrogen or halogen, and pharmacologically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and use thereof in the treatment of circular disorders, are disclosed.

摘要翻译： 选自由下式表示的异喹啉磺酰胺：其中R 1，R 2和R 3可以相同或不同，并且各自表示氢或低级烷基，X表示氢或卤素，以及其药学上可接受的酸加成盐 ，其药物组合物及其在治疗循环障碍中的用途。

公开(公告)号：US4528287A

公开(公告)日：1985-07-09

申请号：US651423

申请日：1984-09-17

申请人： Yasuo Itoh ,  Hideo Kato ,  Nobuo Ogawa ,  Eiichi Koshinaka ,  Tomio Suzuki ,  Noriyuki Yagi

发明人： Yasuo Itoh ,  Hideo Kato ,  Nobuo Ogawa ,  Eiichi Koshinaka ,  Tomio Suzuki ,  Noriyuki Yagi

IPC分类号： C07D401/02 ,  C07D215/56 ,  A61K31/47 ,  C07D401/04

CPC分类号： C07D215/56

摘要： The invention is concerned with the novel piperazinylquinoline-3-carboxylic acids represented by formula (I) ##STR1## or a pharmacologically-acceptable salt thereof, a process for the preparation of them, and a pharmaceutical composition which contains these new compounds as active ingredient and can be used as the therapeutic agent against bacteria.

摘要翻译： 本发明涉及由式（I）表示的新型哌嗪基喹啉-3-羧酸或其药学上可接受的盐，其制备方法和含有这些新化合物的药物组合物 作为活性成分，可以用作抗细菌的治疗剂。

公开(公告)号：US4612329A

公开(公告)日：1986-09-16

申请号：US786742

申请日：1985-10-11

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Hiroyuki Nishino ,  Toshihiko Yoshida

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Hiroyuki Nishino ,  Toshihiko Yoshida

IPC分类号： A61K31/275 ,  A61K31/445 ,  C07C20060101 ,  C07C255/58 ,  C07D20060101 ,  C07D211/08 ,  C07D295/08 ,  C07C121/78

CPC分类号： C07C255/00

摘要： Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cartino vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.

摘要翻译： 公开了用于治疗纸浆血管疾病，外周循环功能不全和脑循环衰竭的新型α-氨基烷基-α-烷基苯基乙腈衍生物。

公开(公告)号：US4983633A

公开(公告)日：1991-01-08

申请号：US241028

申请日：1988-09-02

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

IPC分类号： A61K31/165 ,  C07C233/12 ,  C07C233/73 ,  C07C235/48 ,  C07C311/15 ,  C07D295/08 ,  C07D295/092 ,  C07D317/68

CPC分类号： C07D295/088 ,  C07C255/00 ,  C07D317/68

摘要： Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.

公开(公告)号：US4912116A

公开(公告)日：1990-03-27

申请号：US136912

申请日：1987-12-22

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kouji Morikawa ,  Toshie Yamauchi

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Kouji Morikawa ,  Toshie Yamauchi

IPC分类号： C07D295/10 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P13/02 ,  A61P15/00 ,  C07D307/79 ,  C07D317/58 ,  C07D405/06

CPC分类号： A61K31/535 ,  A61K31/40 ,  A61K31/445 ,  A61K31/55 ,  Y10S514/906

摘要： A method for the treatment of pollakiurea in a subject in need thereof, comprising the step of administering to said subject an effective antipollakiurea amount of a propiophenone of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each independently represents hydrogen, halogen, lower alkyl- or halogeno-lower-alkyl, lower-alkoxy, or cycloalkyl having 3-8 carbon atoms, two of which R.sub.1, R.sub.2, and R.sub.3 groups may combine to form methylenedioxy or ethyleneoxy, R.sub.4 represents hydrogen or a lower-alkyl, and A represents pyrrolidinyl-, piperidinyl-, morpholinyl-, or azepinyl or a pharmaceutically-acceptable acid addition salt thereof, is disclosed.

公开(公告)号：US4534980A

公开(公告)日：1985-08-13

申请号：US633139

申请日：1984-07-23

申请人： Yasuo Itoh ,  Hideo Kato ,  Kugako Matsumura ,  Tomoyasu Nishikawa ,  Akira Hisano ,  Takehisa Yamada ,  Eiichi Koshinaka

发明人： Yasuo Itoh ,  Hideo Kato ,  Kugako Matsumura ,  Tomoyasu Nishikawa ,  Akira Hisano ,  Takehisa Yamada ,  Eiichi Koshinaka

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K31/165 ,  A61K31/19 ,  A61K47/00 ,  A61K47/16 ,  A61K47/18 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00

CPC分类号： A61K9/0014 ,  A61K31/165 ,  A61K31/19 ,  A61K47/18 ,  Y10S514/871

摘要： Creams for external or topical use comprising ketoprofen as an effective component and crotamiton as an agent for preventing crystalline precipitation of the effective component. The creams possess an antiinflammatory and antipyretic effect and are excellent in permeation and absorption into the skin which enables the topical and external use of the creams.

摘要翻译： 用于外用或局部用途的霜剂，其包含酮洛芬作为有效成分，克罗他米通作为用于防止有效成分的结晶沉淀的试剂。 乳霜具有抗炎和解热作用，并且在皮肤中的渗透和吸收优异，能够局部和外部使用霜剂。

公开(公告)号：US07139201B2

公开(公告)日：2006-11-21

申请号：US11243985

申请日：2005-10-06

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G11C11/34

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3445 ,  G11C16/3454 ,  G11C16/3459 ,  G11C29/34 ,  G11C29/52

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite operation, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

摘要翻译： 可以缩短程序验证和擦除验证操作所需的时间。 即使重复执行写入和擦除操作，也可以抑制存储单元的阈值变化。 在编程和擦除操作之后，可以根据每个位线上的电位的预充电之后的所有位线同时判断操作，而不改变列地址。 在数据重写操作中，通过改变数据寄存器中的数据，对具有一次适当写入的数据的存储单元不进行重写操作。

公开(公告)号：US06781895B1

公开(公告)日：2004-08-24

申请号：US09722474

申请日：2000-11-28

申请人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

发明人： Tomoharu Tanaka ,  Masaki Momodomi ,  Hideo Kato ,  Hiroto Nakai ,  Yoshiyuki Tanaka ,  Riichiro Shirota ,  Seiichi Aritome ,  Yasuo Itoh ,  Yoshihisa Iwata ,  Hiroshi Nakamura ,  Hideko Odaira ,  Yutaka Okamoto ,  Masamichi Asano ,  Kaoru Tokushige

IPC分类号： G11C700

CPC分类号： G11C29/785 ,  G06F11/1008 ,  G06F11/1068 ,  G06F2201/81 ,  G06F2212/2022 ,  G11C16/10 ,  G11C16/12 ,  G11C16/24 ,  G11C16/3436 ,  G11C16/344 ,  G11C16/3445 ,  G11C16/3454 ,  G11C16/3459 ,  G11C29/34 ,  G11C29/52

摘要： The time required for the program verify and erase verify operations can be shortened. The change of threshold values of memory cells can be suppressed even if the write and erase operations are executed repetitively. After the program and erase operations, whether the operations were properly executed can be judged simultaneously for all bit lines basing upon a change, after the pre-charge, of the potential at each bit line, without changing the column address. In the data rewrite oepration, the rewrite operation is not effected for a memory cell with the data once properly written, by changing the data in the data register.

摘要翻译： 可以缩短程序验证和擦除验证操作所需的时间。 即使重复执行写入和擦除操作，也可以抑制存储单元的阈值变化。 在编程和擦除操作之后，可以根据每个位线上的电位的预充电之后的所有位线同时判断操作，而不改变列地址。 在数据重写过程中，通过改变数据寄存器中的数据，对数据一次正确写入的存储单元不会影响重写操作。