公开(公告)号：US4985573A

公开(公告)日：1991-01-15

申请号：US355623

申请日：1989-05-23

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

IPC分类号： C07D311/24 ,  C07D491/10 ,  C07D495/10

CPC分类号： C07D491/10 ,  C07D311/24 ,  C07D495/10

摘要： Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group, in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitrogen or oxygen atom, ##STR3## in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group,X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group.The derivatives and salts thereof are useful for the treatment of complications of diabetes.

摘要翻译： 乙内酰脲衍生物及其盐，其中间体，其制备方法和含有该衍生物的药物，其中所述衍生物具有式“IMAGE”，其中V和W之一是氢，另一个是卤代甲基，1H-四唑 - 其中R为氢原子，烷基， - （CH 2 CH 2 O）n CH 3基（n为1至113的整数）或取代的苯基，其中R 1和R 2相同的-COOR基团 或独立地不同，各自为氢原子，烷基，取代的苯基或 - （CH 2 CH 2 O）n CH 3基团（n具有所述的含义）或R 1可以与R 2和氮或氧原子一起形成杂环， 其中R3和R4独立地相同或不同，各自为氢原子或烷基，X为氧或硫原子，Y和Z独立地相同或不同，各自为氢原子，卤素原子，烷基，烷氧基 基团，烷基巯基，硝基或-NHR 5基团 ch R5是氢原子或酰基。 其衍生物和盐可​​用于治疗糖尿病并发症。

公开(公告)号：US5561489A

公开(公告)日：1996-10-01

申请号：US419928

申请日：1995-04-11

申请人： Takuji Yamaguchi ,  Masasuke Funase

发明人： Takuji Yamaguchi ,  Masasuke Funase

IPC分类号： G03D3/13 ,  G03D13/00 ,  G03D3/08

CPC分类号： G03D3/132 ,  G03D13/003 ,  G03D3/135

摘要： An automatic film developing apparatus for developing a photographic film being guided by a leader, comprising a film separating and forming mechanism for separating the developed film conveyed from the developing section of the apparatus from the leader, and forming the separated portion of the film into a specified shape. The developed film is automatically separated from the leader by the film separating and forming mechanism, and, at the same time, the separated portion is formed in a predetermined shape so as not to be caught in the guide of the negative mask or in a predetermined shape so as to be easily wound up in the cartridge, thereby saving the labor and enhancing the job efficiency.

摘要翻译： 一种用于显影由引导件引导的照相胶片的自动胶片显影装置，包括一个胶片分离和形成机构，用于将从装置的显影部分输送的显影胶片与引导件分离，并将胶片的分离部分形成为 指定形状。 显影的膜通过膜分离和形成机构自动地与引导件分离，并且同时，分离部分形成为预定的形状，以便不被捕获在负面掩模的引导件中或以预定的形式 形状，以便容易地卷绕在盒中，从而节省劳动力并提高作业效率。

公开(公告)号：US5521216A

公开(公告)日：1996-05-28

申请号：US182028

申请日：1994-05-12

申请人： Yasushi Igarashi ,  Takuji Yamaguchi ,  Kunio Hosaka

发明人： Yasushi Igarashi ,  Takuji Yamaguchi ,  Kunio Hosaka

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P3/08 ,  A61P3/10 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/12 ,  C07D311/54 ,  C07D311/16

CPC分类号： C07D311/54

摘要： The present invention relates to a chromone derivative of formula (1): ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and independently represent a hydrogen atom or a lower alkyl group) as well as a synthetic intermediate thereof and an aldose reductase inhibitor comprising said derivative as an active ingredient. The chromone derivatives of the present invention can be easily synthesized, and are useful as aldose reductase inhibitor with an excellent inhibitory action on aldose reductase.

摘要翻译： PCT No.PCT / JP93 / 00699 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年5月26日PCT公布。 第WO93 / 24477号PCT公告 本发明涉及式（1）的色酮衍生物：其中R1和R2相同或不同并且独立地表示氢原子或低级烷基）作为 以及其合成中间体和包含所述衍生物作为活性成分的醛糖还原酶抑制剂。 本发明的色酮衍生物可以容易地合成，可用作对醛糖还原酶具有优异抑制作用的醛糖还原酶抑制剂。

公开(公告)号：US5475463A

公开(公告)日：1995-12-12

申请号：US219935

申请日：1994-03-30

申请人： Takuji Yamaguchi ,  Tohgo Kinoshita ,  Yasunobu Shimamura ,  Yuji Yamazoe ,  Shinji Fukushima ,  Masayuki Kojima

发明人： Takuji Yamaguchi ,  Tohgo Kinoshita ,  Yasunobu Shimamura ,  Yuji Yamazoe ,  Shinji Fukushima ,  Masayuki Kojima

IPC分类号： G03D3/13 ,  G03D13/00 ,  G03D3/08

CPC分类号： G03D13/003 ,  G03D3/135

摘要： Various arrangements are proposed for coupling films to a leader. A hole is formed in one of the films and the leader to receive a tab which is formed on the other. These arrangements allow stable coupling of the films to the leader and easy uncoupling. They eliminate the use of splice tape.

摘要翻译： 提出了将膜耦合到引导件的各种布置。 在一个膜和引导件中形成孔，以接收在另一个上形成的突片。 这些布置允许膜稳定地连接到引导件并且易于解耦。 它们消除了使用拼接胶带。

公开(公告)号：US5463441A

公开(公告)日：1995-10-31

申请号：US219473

申请日：1994-03-29

申请人： Takuji Yamaguchi

发明人： Takuji Yamaguchi

IPC分类号： B65H19/10 ,  G03D3/13 ,  G03D13/00 ,  G03D3/08

CPC分类号： G03D3/135 ,  G03D13/003

摘要： There are disclosed a leader for use in developing a film, methods for attaching the leader to the film and for detaching it therefrom, and an apparatus for automatically attaching the leader to the film and detaching it therefrom. The apparatus for automatically attaching the leader to the film includes a leader set cover for holding the leader, a leader guide defining an arcuate path, leader feed means for feeding the leader from the leader set cover to the leader guide, leader backing means for backing the leader to a leader controlling part to curve the leader, and film feed means for feeding the film toward an elongated opening of the leader.

摘要翻译： 已经公开了用于显影胶片的领导者，将引导件附接到胶片上并将其从中分离的方法，以及用于将引导件自动地附接到胶片并从纸张上拆下的装置。 用于将引导件自动附接到胶片的装置包括用于保持引导件的引导件组盖，限定弓形路径的引导引导件，用于将引导件从引导器组盖子馈送到引导引导件的引导器输送装置， 领导者控制部分的领导者，以引导领导者，以及胶片馈送装置，用于将胶卷送入领导者的细长开口。

公开(公告)号：US5373338A

公开(公告)日：1994-12-13

申请号：US44391

申请日：1993-04-08

申请人： Takuji Yamaguchi ,  Yuji Yamamoto ,  Hiroshi Minami

发明人： Takuji Yamaguchi ,  Yuji Yamamoto ,  Hiroshi Minami

IPC分类号： G03D13/00 ,  G03D3/08

CPC分类号： G03D13/003

摘要： A film feeding apparatus feeds films in cartridges secured to leaders into a film developing section, A film insertion box provided adjacent to the film developing section has a film setting chamber and a film feeding chamber. An inlet slit is formed in the film feeding chamber. Mounted in the film feeding chamber are a first carrier device for feeding the leaders inserted into the slit downwards with the cartridges disposed thereunder, a second carrier device (50) for intermittently feeding the leaders toward a deep area of the film feeding chamber, and a third carrier device for feeding the leaders up into the film setting chamber. In the chamber are provided leader guides for guiding the leaders toward the film developing section, and an infeed device for feeding the leaders into the film developing section.

摘要翻译： 胶片供给装置将固定在前头的盒中的胶片送入胶片显影部。与胶片显影部相邻设置的胶片插入盒具有胶片设定室和胶片供给室。 在送膜室中形成入口狭缝。 安装在胶片供给室中的是第一载体装置，用于将插入到狭缝中的引导件向下进给，其中设置在其下方的墨盒，第二载体装置（50），用于间歇地将引导物送入胶片输送室的深部区域， 第三载体装置，用于将引导件送入胶片设置室。 在室中设置有引导引导件朝向胶片显影部分的引导引导件，以及用于将引导件送入胶片显影部分的进给装置。

公开(公告)号：US5001240A

公开(公告)日：1991-03-19

申请号：US507608

申请日：1990-04-12

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai

IPC分类号： C07D311/24 ,  C07D491/10 ,  C07D491/107 ,  C07D495/10

CPC分类号： C07D491/10 ,  C07D311/24 ,  C07D495/10

摘要： Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivatives, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group,in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## group, in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitrogen or oxygen atom, --CH.sub.2 OR.sub.3 group or ##STR3## group, in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group,X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group.The derivatives and salts thereof are useful for the treatment of complications of diabetes.

公开(公告)号：US4861792A

公开(公告)日：1989-08-29

申请号：US90729

申请日：1987-08-28

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

IPC分类号： C07D311/24 ,  C07D491/10 ,  C07D491/107 ,  C07D495/10

CPC分类号： C07D491/10 ,  C07D311/24 ,  C07D495/10

摘要： Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group,in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitrogen or oxygen atom, ##STR3## in which R.sub.2 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group,X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group.The derivatives and salts thereof are useful for the treatment of complications of diabetes.

公开(公告)号：US4734411A

公开(公告)日：1988-03-29

申请号：US895099

申请日：1986-08-11

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Toshinao Usui ,  Ryoichi Unno ,  Hiromoto Kimura ,  Masato Fukushima ,  Mitsuru Oka ,  Shinichi Ikeda ,  Noboru Kuboyama ,  Takashi Ito ,  Seiji Miyano ,  Kunihiro Sumoto

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Toshinao Usui ,  Ryoichi Unno ,  Hiromoto Kimura ,  Masato Fukushima ,  Mitsuru Oka ,  Shinichi Ikeda ,  Noboru Kuboyama ,  Takashi Ito ,  Seiji Miyano ,  Kunihiro Sumoto

IPC分类号： A61K31/40 ,  A61K31/54 ,  A61P1/04 ,  C07D487/04 ,  C07D519/00 ,  C07F7/08 ,  A61K31/55 ,  C07D521/00

CPC分类号： C07D487/04 ,  C07F7/0814

摘要： Novel pyrrolizidine compounds represented by the formula ##STR1## wherein R is a radical of ##STR2## R.sup.1 is hydrogen, halogen, alkyl group, alkoxy group, alkanoyl group, trifluoromethyl radical, trimethylsilyl radical or ##STR3## R.sup.2 and R.sup.3 are same or different and are hydrogen or alkyl group, respectively, R.sup.4 is hydrogen, halogen, alkyl group or alkoxy group and m is an integer of 0 to 5,salts thereof, a process for the preparation of same as well as a pharmaceutical agent comprising same.

摘要翻译： 由式（I）表示的新型吡咯烷酮化合物，其中R是R 1的基团是氢，卤素，烷基，烷氧基，烷酰基，三氟甲基，三甲基甲硅烷基或者R 2是 相同或不同，分别为氢或烷基，R4为氢，卤素，烷基或烷氧基，m为0-5的整数，其盐，其制备方法以及药剂，其包含 相同。

公开(公告)号：US5984227A

公开(公告)日：1999-11-16

申请号：US252934

申请日：1999-02-19

申请人： Takuji Yamaguchi ,  Masasuke Funase

发明人： Takuji Yamaguchi ,  Masasuke Funase

IPC分类号： G03D15/00 ,  B65H19/12 ,  G03D13/00 ,  G03B23/02

CPC分类号： G03D13/003

摘要： A film-rewinding apparatus to rewind a film from a cartridge into a container which can accommodate the film therein by inserting the film from an opening of the container. The apparatus comprises a cartridge-supporting portion which supports the cartridge; a shielding door driving mechanism for opening and closing the shielding door; a spool-driving mechanism for feeding the film out by driving the spool; a container-supporting portion for supporting the container; an opening and closing driving mechanism for opening and closing the opening; and a film-dismounting mechanism for dismounting the film from the spool. The film-rewinding apparatus can easily perform rewinding by only operating a handle or lever, or by a switching operation, after the cartridge and the intermediate magazine are set and the cover is locked.

摘要翻译： 一种胶片重绕装置，用于将胶片从胶卷盒中倒带到容器中，该容器可以通过从容器的开口插入胶片来容纳胶片。 该装置包括支撑盒的盒支撑部分; 用于打开和关闭屏蔽门的屏蔽门驱动机构; 卷轴驱动机构，用于通过驱动卷轴来输送胶卷; 用于支撑容器的容器支撑部分; 用于打开和关闭开口的打开和关闭驱动机构; 以及用于从卷轴拆卸胶片的胶片拆卸机构。 在盒和中间盒被设置并且盖被锁定之后，通过仅操作手柄或杠杆或通过切换操作，胶卷重绕装置可以容易地进行倒带。