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    Hydantoin derivatives for treating complications of diabetes
    2.
    发明授权
    Hydantoin derivatives for treating complications of diabetes 失效
    用于治疗糖尿病并发症的乙内酰脲衍生物

    公开(公告)号：US4985573A

    公开(公告)日：1991-01-15

    申请号：US355623

    申请日：1989-05-23

    申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

    发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

    IPC分类号： C07D311/24 ,  C07D491/10 ,  C07D495/10

    CPC分类号： C07D491/10 ,  C07D311/24 ,  C07D495/10

    摘要： Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group, in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitrogen or oxygen atom, ##STR3## in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group,X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group.The derivatives and salts thereof are useful for the treatment of complications of diabetes.

    摘要翻译： 乙内酰脲衍生物及其盐，其中间体，其制备方法和含有该衍生物的药物，其中所述衍生物具有式“IMAGE”，其中V和W之一是氢，另一个是卤代甲基，1H-四唑 - 其中R为氢原子，烷基， - （CH 2 CH 2 O）n CH 3基（n为1至113的整数）或取代的苯基，其中R 1和R 2相同的-COOR基团 或独立地不同，各自为氢原子，烷基，取代的苯基或 - （CH 2 CH 2 O）n CH 3基团（n具有所述的含义）或R 1可以与R 2和氮或氧原子一起形成杂环， 其中R3和R4独立地相同或不同，各自为氢原子或烷基，X为氧或硫原子，Y和Z独立地相同或不同，各自为氢原子，卤素原子，烷基，烷氧基 基团，烷基巯基，硝基或-NHR 5基团 ch R5是氢原子或酰基。 其衍生物和盐可​​用于治疗糖尿病并发症。

    Hydantoin derivatives for treating complications of diabetes
    4.
    发明授权
    Hydantoin derivatives for treating complications of diabetes 失效
    用于治疗糖尿病并发症的乙内酰脲衍生物

    公开(公告)号：US5447946A

    公开(公告)日：1995-09-05

    申请号：US311005

    申请日：1994-09-23

    申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

    发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Kenji Miura ,  Toshinao Usui ,  Naofumi Terada ,  Kyoichi Asano ,  Kuniharu Mizuno ,  Akira Matsubara ,  Noriaki Kato ,  Kiichi Sawai ,  Ryoichi Unno ,  Hiroshi Ozawa ,  Masato Fukushima

    IPC分类号： C07D311/24 ,  C07D491/10 ,  C07D491/107 ,  C07D495/10 ,  A61K31/415 ,  C07D405/02

    CPC分类号： C07D491/10 ,  C07D311/24 ,  C07D495/10

    摘要： Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group,in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitogen or oxygen atom,--CH.sub.2 OH.sub.3 group or ##STR3## group, in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group,X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group.The derivatives and salts thereof are useful for the treatment of complications of diabetes.

    摘要翻译： 乙内酰脲衍生物及其盐，其中间体，其制备方法和含有该衍生物的药物，其中所述衍生物具有下式的化合物：其中V和W之一是氢，另一个是卤代甲基，1H-四唑 - 其中R为氢原子，烷基， - （CH 2 CH 2 O）n CH 3基（n为1至113的整数）或取代的苯基，其中R 1和R 2相同的-COOR基团 或独立地不同，各自为氢原子，烷基，取代的苯基或 - （CH 2 CH 2 O）n CH 3基（n具有所述的含义）或R 1可以与R 2和硝基或氧原子一起形成杂环，-CH 2 OH 3基 或基，其中R3和R4独立地相同或不同，各自为氢原子或烷基，X为氧或硫原子，Y和Z各自独立地相同或不同，各自为氢原子，卤素 原子，烷基，烷氧基，烷基巯基，硝基 或-NHR 5基团，其中R 5是氢原子或酰基。 其衍生物和盐可​​用于治疗糖尿病并发症。