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公开(公告)号：US12051488B2
公开(公告)日：2024-07-30
申请号：US17163438
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC分类号： G16H10/20 , G06F30/27 , G06N5/04 , G06N20/00 , G06Q10/067 , G06Q10/101 , G16H40/20 , G16H50/50 , G06F3/0484 , G06F111/06
CPC分类号： G16H10/20 , G06F30/27 , G06N5/04 , G06N20/00 , G06Q10/067 , G06Q10/101 , G16H40/20 , G16H50/50 , G06F3/0484 , G06F2111/06
摘要： A method for trial design includes presenting on a graphical interface, a set of cards, wherein each card in the set is representative of a different trial design from a set of trial designs. The method further includes: monitoring a first set of user interactions with the set of cards; determining a user preference for one or more values of one or more parameters of the set of trial designs from the first set of user interactions; and presenting on the graphical interface a new card that is representative of a trial design consistent with the determined user preference. The method may also include monitoring a second set of user interactions with the new card and refining the determined user preference based at least in part on the second set of user interactions with the new card.
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12.发明申请公开(公告)号：US20210319158A1
公开(公告)日：2021-10-14
申请号：US17354639
申请日：2021-06-22
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes generating a plurality of base datasets using a random number generator and determining scenario specifications. The method may further include identifying at least one transformation function for at least one of the plurality of base datasets based on the scenario specifications and transforming the at least one of the plurality of base datasets using the at least one transformation function. In some cases, the method may also include generating scenario parameters based on the at least one transformed datasets.
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公开(公告)号：US20210241862A1
公开(公告)日：2021-08-05
申请号：US17163432
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC分类号： G16H10/20
摘要： A method, according to some implementations, includes receiving, via at least one processor, output data of a plurality of trial design simulations for a plurality of scenarios and evaluating, via the at least one processor, the output data to determine changes in performance over the plurality of scenarios. The method may further include generating, via the at least one processor, visual tornado diagram data structured to generate a visual tornado diagram on an electronic display of an electronic device and transmitting, via the at least one processor, the visual tornado diagram data to the electronic device.
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公开(公告)号：US20210240886A1
公开(公告)日：2021-08-05
申请号：US17163435
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes displaying an interface structured to evaluate design data by a group of users and identifying user parameters for each user in the group. The method ma further include configuring the interface for each user in the group based at least in part on the user parameters, receiving, via the interface, user input data from one or more users in the group, and scoring designs based on the user input and user parameters.
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公开(公告)号：US12040059B2
公开(公告)日：2024-07-16
申请号：US17163425
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC分类号： G16H10/20 , G06F30/10 , G06F30/12 , G06F30/20 , G06N5/04 , G06N20/00 , G06Q10/0631 , G06Q10/067 , G06Q30/0204 , G16H40/20 , G16H50/70 , G06F111/02 , G06F111/04 , G06F111/06 , G06F111/08 , G06F111/16
CPC分类号： G16H10/20 , G06F30/10 , G06F30/12 , G06F30/20 , G06N5/04 , G06N20/00 , G06Q10/06315 , G06Q10/067 , G06Q30/0205 , G16H40/20 , G16H50/70 , G06F2111/02 , G06F2111/04 , G06F2111/06 , G06F2111/08 , G06F2111/16
摘要： A method for determining trial designs is provided. The method includes receiving, via at least one processor, one or more trial design criteria and one or more scenarios corresponding to a set of trial designs, and generating, via the at least one processor, simulation data based at least in part on replicating each of the set of trial designs with the one or more trial design criteria and the one or more scenarios. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria. The method further includes determining, via the at least one processor, an optimality criteria for evaluating the trial designs, searching, within the set of trial designs, via the at least one processor, for globally optimum designs based on the optimality criteria, and transmitting, via the at least one processor, globally optimum designs.
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公开(公告)号：US20240004910A1
公开(公告)日：2024-01-04
申请号：US18344205
申请日：2023-06-29
申请人： Cytel Inc.
发明人： Reza Jafar , Anna Forsythe , Kristian Thorlund , Junhan Liu
CPC分类号： G06F16/3346 , G06F16/3334 , G06F16/35
摘要： Publication pre-screening may include the use of a trained model. A trained language model may be fine-tuned on a question-and-answer task and may be configured to receive a question that includes inclusion and exclusion criteria for a publication. The question may be formulated to include context information such as a title and abstract of the publication. An output of the model may be used to determine a selection of the publication.
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公开(公告)号：US20220382935A1
公开(公告)日：2022-12-01
申请号：US17847025
申请日：2022-06-22
申请人： Cytel Inc.
发明人： Nitin Patel , Jaydeep Bhattacharyya , Albert M. Kim , Yannis Jemiai , Jay Kyle Wathen , Sagar Mehta , Christopher Michael Porayko
IPC分类号： G06F30/20
摘要： A method, according to some implementations, receiving, for each trial design of a set of trial designs, a simulated performance and presenting, for at least two criteria, a plot of the simulated performance. The method may further include presenting, for at least one additional criteria, a plurality of contour lines on the plot and selecting a subset of the set of trial designs based on the plurality of contour lines.
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公开(公告)号：US20210241865A1
公开(公告)日：2021-08-05
申请号：US17163437
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes providing inputs to a plurality of trial design simulation engines, receiving first outputs of the plurality of trial design simulation engines in response to the inputs, and providing variations of the inputs to the plurality of trial design simulation engines. The method may further include receiving second outputs of the plurality of trial design simulation engines in response to the variations evaluating the first and the second outputs to determine delta values, and determining, based in part on the delta values, a plurality of normalization factors for the plurality of trial design simulation engines.
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公开(公告)号：US20210241861A1
公开(公告)日：2021-08-05
申请号：US17163431
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method, according to some implementations, includes determining, via at least one processor, a plurality of possible sites for recruiting patients from for a trial and determining, via the at least one processor and for each of one or more subgroupings of the plurality of possible sites, a predicted patient recruitment value. The method may include determining, via the at least one processor, a candidate subgrouping of the plurality of possible sites having a predicted patient recruitment value that globally optimizes a desired site selection criteria, and transmitting, via the at least one processor, data corresponding to the candidate subgrouping.
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公开(公告)号：US20210240885A1
公开(公告)日：2021-08-05
申请号：US17163430
申请日：2021-01-30
申请人： Cytel Inc.
发明人： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
摘要： A method for trial design with pareto techniques is provided. The method includes obtaining trial design simulation results for a set of trial designs and determining a score for each trial design based on a performance criteria. The method further includes evaluating Pareto optimality for each design in the set of trial designs to determine a Pareto frontier, filtering designs that are not on the Pareto frontier, and communicating the Pareto frontier designs.
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