利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

116 条记录 (耗时 0.028 秒)

    PREPARATION OF CHALCONE DERIVATIVES
    12.
    发明申请
    PREPARATION OF CHALCONE DERIVATIVES 有权
    喹诺酮衍生物的制备

    公开(公告)号：US20130131372A1

    公开(公告)日：2013-05-23

    申请号：US13698832

    申请日：2011-05-16

    申请人： Karine Bertrand ,  Alice Roudot ,  Patrice Rool

    发明人： Karine Bertrand ,  Alice Roudot ,  Patrice Rool

    IPC分类号： C07C319/12 ,  C07C67/08 ,  C07C45/45

    CPC分类号： C07C319/12 ,  C07C45/45 ,  C07C67/08 ,  C07C67/31 ,  C07C319/20 ,  C07C69/738 ,  C07C323/22

    摘要： The invention relates to methods for producing chalcone (1,3-diphenylprop-2-en-1-one) derivatives that have multiple substitutions on a phenyl ring. Intermediate chalcone derivatives are modified by Phase Transfer Catalysis (PTC) for introducing a substituted alkyl group that is provided by a sulfonic acid derivative on a phenyl ring already containing substituent groups on one or two carbon atoms adjacent to the carbon atom where a substituent group is being introduced. The methods of the invention allow producing efficiently, by either S-alkylation or O-alkylation, chalcones derivatives that are characterized for their biological activities that are intermediate compounds for producing molecules having such activities, or that can be used for generating libraries of compounds to be screened by means of in vitro and/or in vivo assays and establishing structure-activity relationships.

    摘要翻译： 本发明涉及在苯环上具有多个取代基的查尔酮（1,3-二苯基丙-2-烯-1-酮）衍生物的方法。 中间查耳酮衍生物通过相转移催化剂（PTC）进行改性，用于将由磺酸衍生物提供的取代的烷基引入到已经含有一个或两个邻近碳原子上的取代基的取代基的苯环上，其中取代基为 被介绍 本发明的方法允许通过S-烷基化或O-烷基化有效生产由其生物活性表征的作为用于产生具有这种活性的分子的中间体化合物的或可以用于产生化合物文库的查尔酮衍生物 通过体外和/或体内测定法筛选并建立结构 - 活性关系。

    Compositions and methods for apo-b48 and apo-b100 assay
    17.
    发明申请
    Compositions and methods for apo-b48 and apo-b100 assay 审中-公开
    apo-b48和apo-b100测定的组合物和方法

    公开(公告)号：US20050152900A1

    公开(公告)日：2005-07-14

    申请号：US10513916

    申请日：2003-06-19

    申请人： Jamila Najib ,  Zouher Majd

    发明人： Jamila Najib ,  Zouher Majd

    IPC分类号： C07K14/775 ,  C07K16/18 ,  A61K39/395

    CPC分类号： C07K14/775 ,  C07K16/18

    摘要： The invention concerns compositions and methods for assay or detection of apolipoprotein-B48 in samples. In particular, it concerns a method for differential measurement of apolipoprotein-B48 (“Apo-B48”) and apolipoprotein-B100 (“Apo-B100”) in biological samples. The invention also concerns synthetic products of Apo-B100, the corresponding antibodies, kits containing same, and their uses for detecting, differentially quantifying and/or recording an amount of Apo-B48 and/or Apo-B100 in a sample, or for quantifying and/or recording atherogenic lipoparticles in a sample. The products, materials and kits hereinabove can also be used for differentially modulating the levels of Apo-B48 and/or Apo-B100 or their activity, in vitro or in vivo, and for regulating lipid metabolism in a subject.

    摘要翻译： 本发明涉及样品中载脂蛋白-B48的测定或检测的组合物和方法。 特别涉及生物样品中载脂蛋白-B48（“Apo-B48”）和载脂蛋白-B100（“Apo-B100”）差异测量的方法。 本发明还涉及Apo-B100的合成产品，相应的抗体，含有该抗体的试剂盒，以及其用于检测，差异量化和/或记录样品中Apo-B48和/或Apo-B100的量的用途，或用于量化 和/或记录样品中的致动脉粥样化脂质颗粒。 上述产品，材料和试剂盒也可以用于在体外或体内差异调节Apo-B48和/或Apo-B100的水平或其活性，并用于调节受试者中的脂质代谢。