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40 条记录 (耗时 0.013 秒)

    Antiviral treatment
    11.
    发明授权
    Antiviral treatment 失效
    抗病毒治疗

    公开(公告)号：US3859433A

    公开(公告)日：1975-01-07

    申请号：US35561073

    申请日：1973-04-30

    申请人： HERCULES INC

    发明人： REGELSON WILLIAM

    IPC分类号： A61K31/765 ,  A61K15/00 ,  A61K23/00

    CPC分类号： A61K31/765 ,  Y10S514/889

    摘要： Certain water-soluble copolymers prepared from divinyl ether and maleic anhydride have been found to suppress virus growth. Administration of said copolymers not only suppresses growth in infected animals but also increases resistance to virus infection in healthy animals by stimulating the production of interferon.

    Pharmaceutical carriers of plasticized dried milled particles of hydrated cooked rice endosperm
    12.
    发明授权
    Pharmaceutical carriers of plasticized dried milled particles of hydrated cooked rice endosperm 失效
    水化碾磨米糠OF OF OF OF ERM ERM ERM ERM ERM ERM ERM ERM ERM ERM ERM ERM ERM

    公开(公告)号：US3806603A

    公开(公告)日：1974-04-23

    申请号：US12153271

    申请日：1971-03-05

    申请人： GAUNT W ,  GAUNT M

    发明人： GAUNT W ,  GAUNT M

    IPC分类号： A61K9/14 ,  A61K9/20 ,  A61K15/00 ,  A61K27/00

    CPC分类号： A61K9/2068 ,  A61K9/146 ,  Y10S514/904 ,  Y10S514/974

    摘要： Water-soluble bad-tasting drugs and vitamins are put into chewable tablet form wherein the drugs and vitamins have a pleasant taste and are readily available upon ingestion. A water solution or water-alcohol solution of the bad-tasting substance is absorbed into rice endosperm using about enough solution for complete hydration or slightly less, followed by drying. Precooked rice endosperm can also be used. The drugs include phenothiazine tranquilizers and barbiturates and the vitamins include thiamin, niacinamide and pyridoxine. The water-soluble substance may constitute up to 60 percent of the finished product, with the rice endosperms, which may be previously comminuted, making up the balance. The pleasant tasting chewable tablets contain the bad tasting substance with the bad taste masked, conventional chewable tablet base constituents for the tableting of the rice endosperm-drug particles being combined with the treated rice endosperms.

    摘要翻译： 将水溶性不良品和维生素加入咀嚼片形式中，其中药物和维生素具有令人愉悦的味道，并且在摄入时容易获得。 使用约足够的溶液进行完全水化或略少，然后干燥，将不良品质的水溶液或水 - 醇溶液吸收到水稻胚乳中。 也可以使用预煮的米胚乳。 药物包括吩噻嗪镇静剂和巴比妥类，维生素包括硫胺素，烟酰胺和吡哆醇。 水溶性物质最多可占成品的60％，其中可能预先粉碎的水稻胚乳弥补了平衡。 令人愉快的品尝咀嚼片包含不良口味掩味的常规咀嚼片基质成分，用于将水稻胚乳药物颗粒与经处理的水稻胚乳结合进行压片。

    Dermal protective film
    13.
    发明授权
    Dermal protective film 失效
    防护膜

    公开(公告)号：US3749772A

    公开(公告)日：1973-07-31

    申请号：US3749772D

    申请日：1970-12-04

    申请人： UNIV AKRON

    发明人： CARDARELLI N ,  MANSDORF S

    IPC分类号： A61K9/70 ,  A61K15/00

    CPC分类号： A61K9/7015

    摘要： COMPOSITION OF MATTER FOR PREVENTING SKIN IRRITATION FROM CONTACT WITH "POISON IVY." THE COMPOSITION IS BASED UPON A FILM-FORMING ACRYLIC POLYMER AND INCLUDES A LINKING AGENT SO THAT UPON APPLICATION BY A SOLVENT CARRIER TO THE SKIN A SELECTIVE MEMBRANE IS FORMED. THE COMPOSITION MAY ALSO INCLUDE AN OXIDIZING AGENT FOR BREAKDOWN OF IRRITATION CAUSING ALLERGENS SELECTIVELY RETAINED BY THE MEMBRANE.

    Pleasant tasting chewable tablets and their production
    14.
    发明授权
    Pleasant tasting chewable tablets and their production 失效
    舒适的品尝茶几及其生产

    公开(公告)号：US3629394A

    公开(公告)日：1971-12-21

    申请号：US3629394D

    申请日：1969-10-13

    申请人： WILLIAM E GAUNT ,  MARJORIE CLAIRE GAUNT

    发明人： GAUNT WILLIAM E ,  GAUNT MARJORIE CLAIRE

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/20 ,  A61K15/00

    CPC分类号： A61K9/0056 ,  A61K9/146 ,  A61K9/2068

    摘要： WATER-SOLUBLE BAD-TASTING DRUGS AND VITAMINS ARE PUT INTO CHEWABLE TABLET FORM WHEREIN THE DRUGS AND VITAMINS HAVE A PLEASTANT TASTE AND ARE READILY AVAILABLE UPON INGESTION. A WATER SOLUTION OR WATER-ALCOHOL SOLUTION OF THE BAD-TASTING SUBSTANCE IS ABSORBED INTO RICE ENDOSPERM USING ABOUT ENOUGH SOLUTION FOR COMPLETE HYDRATION OR SLIGHTLY LESS, FOLLOWED BY DRYING. PRECOOKED RICE ENDOSPERM CAN ALSO BE USED. THE DRUGS INCLUDE PHENOTHIAZINE TRANQUILIZERS AND BARBITURATES AND THE VITAMINS INCLUDE THIAMIN, NIACINAMIDE AND PYRIDOXINE. THE WATER-SOLUBLE SUBSTANCE MAY CONSTITUTE UP TO 60% OF THE FINISHED PRODUCT, WITH THE RICE ENDOSPERMS, WHICH MAY BE PREVIOUSLY COMMINUTED, MAKING UP THE BALANCE. THE PLEASANT TASTING CHEWABLE TABLETS CONTAIN THE BAD TASTING SUBSTANCE WITH THE BAD TASTE MASKED, CONVENTIONAL CHEWABLE TABLET BASE CONSTITUENTS FOR THE TABLETING OF THE RICE ENDOSPERM-DRUG PARTICLES BEING COMBINED WITH THE TREATED RICE ENDOSPERMS.

    Quick-liquifying, chewable tablet
    18.
    发明授权
    Quick-liquifying, chewable tablet 失效
    快速液化，咀嚼片

    公开(公告)号：US4684534A

    公开(公告)日：1987-08-04

    申请号：US702818

    申请日：1985-02-19

    申请人： William Valentine

    发明人： William Valentine

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K15/00 ,  A61K21/00

    CPC分类号： A61K9/0056 ,  A61K9/2095 ,  Y10S514/96

    摘要： This application discloses tablets having a harder outer shell which inhibits penetration of liquid into the interior of the tablet, and a softer interior which quickly liquifies when the tablet and shell are broken into pieces and contacted by the liquid. The tablet has particular utility as a chewable tablet which resists absorption of moisture but which quickly liquifies and melts in the mouth within seconds after mastication, even if the tablet contains considerable amounts of active ingredients that do not dissolve well or at all in the mouth. Also disclosed are agglomerates from which the tablets are directly compressed, and processes for making the agglomerates and tablets. The tablets contain increased quantities of active ingredients of up to about 75% by weight. The excipient or base material of the tablet is made from carbohydrates including dextrose, dextrose monohydrate, maltodextrin, fructose, sucrose, lactose, maltose and xylose held together by small quantities of a carbohydrate binder such as maltodextrin. Tablets according to the invention can contain active ingredients such a pharmaceuticals (e.g., antacids, analgesics, cough medicine, drugs, etc.) breath sweeteners, vitamins and dietary supplements, to name a few.

    摘要翻译： 本申请公开了具有较硬外壳的片剂，其抑制液体进入片剂内部的渗透性，以及较软的内部，当片剂和壳体被破碎成块并被液体接触时，其迅速液化。 该片剂作为咀嚼片具有特别的用途，其抗吸收水分，但在咀嚼后几秒钟内即可快速液化和熔化口腔，即使片剂含有相当量的不能很好地溶解或完全溶解于口中的活性成分。 还公开了直接压制片剂的附聚物，以及用于制备附聚物和片剂的方法。 片剂含有高达约75重量％的增加量的活性成分。 片剂的赋形剂或基材由碳水化合物制成，包括葡萄糖，葡萄糖一水合物，麦芽糖糊精，果糖，蔗糖，乳糖，麦芽糖和木糖，通过少量的碳水化合物粘合剂如麦芽糖糊精组合在一起。 根据本发明的片剂可以含有活性成分，例如药物（例如抗酸剂，止痛剂，止咳药，药物等）呼吸甜味剂，维生素和膳食补充剂。

    Xanthines in pharmaceutical preparations and for stabilization of vitamins
    20.
    发明授权
    Xanthines in pharmaceutical preparations and for stabilization of vitamins 失效
    药物制剂中的黄嘌呤和维生素的稳定化

    公开(公告)号：US3864469A

    公开(公告)日：1975-02-04

    申请号：US33065473

    申请日：1973-02-08

    申请人： HOECHST AG

    发明人： REISER MARIO ,  NOOK LOTHAR ,  EIDEBENZ EMIL

    IPC分类号： A61K31/52 ,  A61K31/525 ,  A61K31/59 ,  A61K27/12 ,  A61K15/00 ,  A61K15/12

    CPC分类号： A61K31/525 ,  A61K31/52 ,  A61K31/59 ,  A61K31/455 ,  A61K31/07 ,  A61K31/51 ,  A61K31/375 ,  A61K31/44 ,  A61K31/355 ,  A61K2300/00

    摘要： The invention relates to a process for the production of pharmaceutical preparations exhibiting delayed release of an active substance which comprises intimately mixing a more slowly absorbable therapeutically-active substance with one which is more rapidly absorbable, one of these therapeutically-active substances being present in the non-solid state in which the other one is homogeneously incorporated, solidifying the mixture obtained and forming it into a solid pharmaceutical preparation. The invention also relates to a process for the stabilization of vitamins in a mixture containing certain substituted xanthines which are also suitable in the afore-mentioned process by homogeneously incorporating one component in the other one which is in the non-solid state, and to preparations comprising a combination of a vitamin stabilized with one of said substituted xanthines.

    摘要翻译： 本发明涉及一种生产显示出延迟释放活性物质的药物制剂的方法，其包括将更缓慢吸收的治疗活性物质与更快吸收的治疗活性物质紧密地混合，这些治疗活性物质之一存在于 非固态，其中另一个被均匀地结合，固化所获得的混合物并将其形成固体药物制剂。 本发明还涉及在含有某些取代黄嘌呤的混合物中使维生素稳定化的方法，其也适用于上述方法中，通过均匀地引入另一种在非固体状态的一种组分，以及制剂 其包含与所述取代的黄嘌呤中的一种稳定的维生素的组合。