利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

370 条记录 (耗时 0.029 秒)

    Electrical device for the release of active substances
    13.
    发明申请
    Electrical device for the release of active substances 有权
    用于释放活性物质的电气装置

    公开(公告)号：US20050249673A1

    公开(公告)日：2005-11-10

    申请号：US10527644

    申请日：2003-03-12

    申请人： Andrea Caserta ,  Julio Ruiz Ballesteros ,  Cedric Morhain

    发明人： Andrea Caserta ,  Julio Ruiz Ballesteros ,  Cedric Morhain

    IPC分类号： A01M1/20 ,  A61L9/03 ,  A61L9/02 ,  A61K9/72

    CPC分类号： A61L9/037 ,  A01M1/2077

    摘要： The device comprises conventionally a plug (2) for the electrical supply of a heater element (14) to bring about the heating and evaporation, by way of a flat wick (10), of an active substance contained in a main receptacle (5). The novelty lies in the fact that said container (5) is heat-formed and defines a triangular configuration reservoir (6) with a flat extension (7) that accommodates the flat “Y”-shaped wick (10) in which the ends of its divergent arms (11) are engaged in recesses (9) in the mouth of the active substance reservoir (6), said wick (10) being pressed by an impermeable strip (12) which is heat-sealed to the body of the reservoir (6), so that the heater element (14) positioned facing the front end of the extension (7) brings about the warming of the wick (10) and the corresponding evaporation of the active substance, which will issue by way of a hole (16) in the impermeable strip (12) to be diffused in the environment. In the plug-in position the device remains with the container (5) of the wick (10) in the vertical position, and in direct contact of this with the active substance contained in the reservoir (6).

    摘要翻译： 该装置通常包括用于供电加热器元件（14）的插头（2），以通过扁平灯芯（10）使包含在主容器（5）中的活性物质实现加热和蒸发， 。 新颖之处在于，所述容器（5）被热成型并且限定具有平坦的延伸部（7）的三角形构造储存器（6），该平坦的延伸部（7）容纳平坦的“Y”形的灯芯（10） 其发散臂（11）接合在活性物质储存器（6）的口中的凹部（9）中，所述芯（10）被不可渗透的带（12）挤压，所述不透液条被热密封到储存器 （6），使得位于延伸部（7）的前端的加热器元件（14）导致油绳（10）的升温和活性物质的相应蒸发，这将通过孔 （16）在不透气条（12）中以在环境中扩散。 在插入位置，装置保持在油绳（10）的容器（5）处于垂直位置，并且与包含在储存器（6）中的活性物质直接接触。

    Method of producing hollow, microporous particles which are intended, in particular to be inhaled
    15.
    发明申请
    Method of producing hollow, microporous particles which are intended, in particular to be inhaled 审中-公开
    制造特别是被吸入的中空微孔颗粒的方法

    公开(公告)号：US20050214226A1

    公开(公告)日：2005-09-29

    申请号：US10501485

    申请日：2003-01-14

    申请人： El Larhrib ,  Joseph Okpala

    发明人： El Larhrib ,  Joseph Okpala

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61L9/04 ,  A61P11/00

    CPC分类号： A61K9/1688 ,  A61K9/0073 ,  A61K9/1694

    摘要： The invention relates to a method of producing hollow, microporous particles which are intended, in particular, to be inhaled or for any other application. The inventive method consists in: providing a composition, in a given form, comprising at least one active principle and at least one blowing agent; cooling the aforementioned composition to below the solidification point of said at least one blowing agent so as to increase the volume of the given form and to create ruptures in the surface and/or in all of said given form, thereby enabling the structure of the hollow, microporous particle to be obtained; and removing all or part of said at least one blowing agent.

    摘要翻译： 本发明涉及一种生产中空微孔颗粒的方法，特别是要被吸入或用于任何其他应用。 本发明的方法在于：提供给定形式的包含至少一种活性成分和至少一种发泡剂的组合物; 将上述组合物冷却至低于所述至少一种发泡剂的固化点，以增加给定形式的体积并在表面和/或所有给定形式中产生破裂，从而使得空心结构 ，得到微孔颗粒; 并且除去所述或部分所述至少一种发泡剂。

    Aerodynamically light particles for pulmonary drug delivery
    18.
    发明授权
    Aerodynamically light particles for pulmonary drug delivery 失效
    用于肺部药物递送的空气动力学轻微颗粒

    公开(公告)号：US06942868B2

    公开(公告)日：2005-09-13

    申请号：US10441948

    申请日：2003-05-20

    申请人： David A. Edwards ,  Giovanni Caponetti ,  Jeffrey S. Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdellaziz Ben-Jebria ,  Robert S. Langer

    发明人： David A. Edwards ,  Giovanni Caponetti ,  Jeffrey S. Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdellaziz Ben-Jebria ,  Robert S. Langer

    IPC分类号： A61K9/12 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61K31/137 ,  A61K47/32 ,  A61K49/00 ,  A61L15/00

    CPC分类号： A61K9/0075 ,  A61K9/1647 ,  A61K31/137

    摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

    摘要翻译： 提供用于向肺系统输送药物的空气动力学轻微颗粒，以及用于其合成和给药的方法。 在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且具有小于0.4g / cm 3的振实密度和5μm和30μm之间的质量平均直径。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的聚（氨基酸）侧链组成 集团在聚酯骨干。 在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻微颗粒可用于增强治疗剂递送至肺的肺泡区域。 掺入治疗剂的空气动力学轻微颗粒可以被有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。