公开(公告)号：US20030138487A1

公开(公告)日：2003-07-24

申请号：US09988223

申请日：2001-11-19

Applicant: Phoqus Limited

Inventor： John E. Hogan ,  Trevor Page ,  Linda Reeves ,  John N. Staniforth

IPC: A61K009/28 ,  B01J013/00

CPC classification number: A61K9/2866 ,  A61J3/005 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/2893 ,  B05B5/08 ,  B05B5/081 ,  B05B5/082 ,  B05B5/087 ,  B05D1/045 ,  B05D1/06 ,  B05D2258/00 ,  F41A17/44 ,  Y10T428/2982

Abstract: An apparatus and method for locking a gun. The apparatus includes a dummy round configured for insertion into a firing chamber of a gun, a locking component configured for coupling with the dummy round, and an elongated sleeve rotatably coupled with the locking component. The locking component includes a keyed head positioned within a longitudinal channel of the elongated sleeve. The locking component and elongated sleeve are insertable through the discharge end of a gun's barrel. An actuating mechanism, such as a key is insertable through the channel of the elongated sleeve to engage with the keyed head and rotate the locking mechanism relative to the elongated sleeve. Rotation of the locking mechanism effects a friction lock between the locking mechanism and the dummy round.

Abstract translation: 一种用于锁定枪的装置和方法。 该装置包括：被配置用于插入到枪的击发室中的虚拟圆形，配置成与虚拟圆形结合的锁定部件，以及与锁定部件可旋转地连接的细长套筒。 锁定部件包括位于细长套筒的纵向通道内的带键头。 锁定部件和细长套筒可通过枪管的排放端插入。 诸如钥匙的致动机构可以通过细长套筒的通道插入以与钥匙头接合并相对于细长套筒旋转锁定机构。 锁定机构的旋转会影响锁定机构和虚拟轮之间的摩擦锁定。

公开(公告)号：US20030091636A1

公开(公告)日：2003-05-15

申请号：US10282383

申请日：2002-10-29

Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.

Inventor： Michael Cappola ,  George W. Gereg ,  Susan Way

IPC: A61K031/724 ,  B05D003/00 ,  B01J013/00 ,  A61K009/28

CPC classification number: B82Y5/00 ,  A61K31/5377 ,  A61K47/6951

Abstract: A formulation comprising, and process for preparing, improved oral dosage forms of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-null4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylnull-urea, a chemical entity with anti-inflammatory properties. Granulation of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-null4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylnull-urea within specified ranges provides improved dissolution of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-null4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylnull-urea and oral bioavailability, as well as content uniformity. Incorporation into the formulation of an aqueous soluble inclusion compound capable of forming a complex with 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-null4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylnull-urea, such as beta-cyclodextrin provides enhanced stability of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-null4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-ylnull-urea, in particular in highly ionic environments. Chipping and disintegration of tablets containing more than about 10% betacyclodextrin can be prevented by applying a polymeric coat to the surface of the tablet at a temperature below 40null C.

Abstract translation: 包含改善口服剂型1-（5-叔丁基-2-对甲苯基-2H-吡唑-3-基）-3- [4-（2-吗啉-4-基 - 乙氧基） - 萘-1-基] - 脲，具有抗炎特性的化学物质。 1-（5-叔丁基-2-对甲苯基-2H-吡唑-3-基）-3- [4-（2-吗啉-4-基 - 乙氧基） - 萘-1-基] - 脲在特定范围内提供1-（5-叔丁基-2-对甲苯基-2H-吡唑-3-基）-3- [4-（2-吗啉-4-基 - 乙氧基） - 萘 -1-基] - 脲和口服生物利用度，以及含量均匀性。 加入能够与1-（5-叔丁基-2-对甲苯基-2H-吡唑-3-基）-3- [4-（2-吗啉-4-基） 乙氧基） - 萘-1-基] - 脲如β-环糊精提供了增强的1-（5-叔丁基-2-对甲苯基-2H-吡唑-3-基）-3 - [4-（2-吗啉-4-基 - 乙氧基） - 萘-1-基] - 脲，特别是在高离子环境中。 通过在低于40℃的温度下将片剂的表面施加聚合物涂层，可以防止包含超过约10％的β-环糊精的片剂的碎裂和崩解。

公开(公告)号：US20020176926A1

公开(公告)日：2002-11-28

申请号：US10047183

申请日：2001-10-23

Inventor： Timothy Allen Pletcher ,  Pabitra Datta ,  Christopher Just Poux ,  Randall Eugene McCoy

IPC: B05D001/04 ,  B05D001/12 ,  A61J001/00 ,  B05D003/00 ,  B01J013/00

CPC classification number: A61K9/0075 ,  A61J3/00 ,  A61K9/0073 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/02 ,  A61M15/025 ,  B05B5/025 ,  B05B5/047 ,  G03G15/04045 ,  G03G15/221 ,  G03G15/323

Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate. Consequently, this apparatus accurately controls both medicament dosage and deposition location. Furthermore, since the substrate can be of any dielectric material that retains an electrostatic charge, the apparatus can be used to deposit medicament on substrates that are presently used in oral medicament consumption, e.g., substrates that are used to fabricate suppositories, inhalants, tablets, capsules and the like.

Abstract translation: 用于在基底上的选定位置静电沉积选择剂量的药物粉末的装置和伴随方法。 具体地，该装置包含用于产生对基板的预定区域充电的带电粒子的带电粒子发射器和用于计算在基板上累积的电荷量并且在已选择的电荷积累时停用发射极的电荷累积控制电路。 此外，摩擦带电装置对药物粉末进行充电，并在基底的带电区域附近形成带电药物云。 药物云内的药物颗粒静电附着到带电区域。 在预定区域上积累在基底上的电荷量和云中的药物粉末的电荷与质量比控制由基底沉积和保留的药物的量（剂量）。 因此，该装置精确地控制药物剂量和沉积位置。 此外，由于衬底可以是保持静电电荷的任何电介质材料，所以该装置可用于在目前用于口服药物消耗的基底上沉积药物，例如用于制造栓剂，吸入剂，片剂， 胶囊等。

公开(公告)号：US20020086908A1

公开(公告)日：2002-07-04

申请号：US09954132

申请日：2001-09-17

Inventor： Chuen-Shyong Chou ,  Edward Ewart LaFleur ,  Dennis Paul Lorah ,  Robert Victor Slone ,  Katerina Dukes Neglia

IPC: B01J013/00

CPC classification number: B82Y30/00 ,  C08F2/00 ,  C08F2/44 ,  C08F265/06 ,  C08F292/00 ,  C08K9/04 ,  C08K9/08 ,  C08K2201/011

Abstract: Processes for utilizing various emulsion polymerization procedures for preparing aqueous nanocomposite dispersions are disclosed. The disclosed processes include both in-situ polymerizations in the presence of at least partially exfoliated unmodified clays as well as admixtures of polymer dispersions with at least partially exfoliated unmodified clay dispersions. The disclosed nanocomposite dispersions are useful for preparing a variety of materials, such as coatings, adhesives, caulks, sealants, plastics additives, and thermoplastic resins. Processes for preparing polymer clay nanocomposite powders and use of these powders as plastic resin and plastics additives are also disclosed.

Abstract translation: 公开了利用各种乳液聚合方法制备水性纳米复合物分散体的方法。 所公开的方法包括在存在至少部分脱落的未改性粘土的情况下的原位聚合以及聚合物分散体与至少部分脱落的未改性粘土分散体的混合物。 所公开的纳米复合物分散体可用于制备各种材料，例如涂料，粘合剂，填缝剂，密封剂，塑料添加剂和热塑性树脂。 还公开了制备聚合物粘土纳米复合粉末和使用这些粉末作为塑料树脂和塑料添加剂的方法。

公开(公告)号：US20040186203A1

公开(公告)日：2004-09-23

申请号：US10805745

申请日：2004-03-22

Inventor： Yasuhiro Koyanagi

IPC: A61J001/00 ,  B05D003/00 ,  B01J013/00 ,  C08J003/00 ,  C08L089/00 ,  C09D001/00

CPC classification number: C23C24/08 ,  C23C4/04 ,  C23C30/00 ,  Y02T50/67

Abstract: A coating material includes sodium in a range of from 0.1% to 10%; magnesium in a range of from 0.01% to 1%; aluminum in a range of from 0.1% to 15%; potassium in a range of from 1% to 30%; silicon in a range of from 10% to 30%; and iron in a range of from 0.1% to 1%.

Abstract translation: 涂层材料包括0.1％至10％范围内的钠; 在0.01％至1％的范围内的镁; 铝在0.1％至15％的范围内; 钾在1％至30％的范围内; 在10％至30％的范围内的硅; 和铁在0.1％至1％的范围内。

公开(公告)号：US20040041306A1

公开(公告)日：2004-03-04

申请号：US10234775

申请日：2002-09-03

Inventor： Anandaraman Subramaniam ,  Anne Reilly

IPC: B01J013/00

CPC classification number: B01J13/10 ,  A23L27/72 ,  A23L29/284 ,  A23P10/30 ,  A23V2002/00 ,  Y10T428/2985 ,  A23V2200/224 ,  A23V2200/266 ,  A23V2250/5028 ,  A23V2250/5432

Abstract: The invention relates to a complex coacervation process based on the use of type B gelatin as polycationic colloid, for the preparation of nullHalalnull certified flavor-containing microcapsules.

Abstract translation: 本发明涉及一种基于B型明胶作为聚阳离子胶体的复合凝聚方法，用于制备“清真”认证的含味微囊。

公开(公告)号：US20030170312A1

公开(公告)日：2003-09-11

申请号：US10333501

申请日：2003-01-21

Inventor： Hassan Benameur ,  Philippe Barthelemy

IPC: A61K009/16 ,  A61K009/50 ,  B05D003/00 ,  B01J013/00 ,  A61K031/192

CPC classification number: A61K9/5089 ,  A61K9/1617 ,  A61K9/1694 ,  A61K9/5015

Abstract: The invention concerns a method for coating solid particles with a thermofusible agent which consists in: fluidizing the solid particles in an ascending air movement in spiral rotation to obtain a homogeneous individualised distribution of the particles in the air fluidized bed, the temperature of the air fluidized bed being lower than the melting point of the thermofusible agent; spraying on the particles the melted thermofusible agent in the form of atomised droplets, said droplets being distributed in a spraying cone included in an air zone, whereof the temperature enables to maintain, throughout said spraying process, a temperature of the thermofusible agent substantially equal its melting point, the spraying being carried out in the same direction and tangentially to the movement followed by the solid particles; finally, after the coating process, cooling the resulting coated particles so as to solidify the thermofusible agent around the particles.

Abstract translation: 本发明涉及用热熔融剂涂覆固体颗粒的方法，该方法包括：以螺旋旋转的上升空气运动使固体颗粒流化，以获得颗粒在空气流化床中的均匀的个体化分布，空气流化的温度 床低于热熔剂的熔点; 以雾化的液滴的形式将熔融的热熔融剂喷涂在颗粒上，所述液滴分布在包括在空气区域中的喷雾锥体中，其中温度使得能够在整个喷涂过程中保持热熔性试剂的温度基本上等于其 熔点，喷涂方向与固体颗粒随后的运动相切地进行; 最后，在涂布过程之后，冷却所得到的涂覆颗粒，以使颗粒周围的热熔体固化。

公开(公告)号：US20030032682A1

公开(公告)日：2003-02-13

申请号：US10255418

申请日：2002-09-26

Inventor： Mark L. Jarand

IPC: B01J013/00

CPC classification number: C09K3/14 ,  D21H19/14 ,  D21H21/14

Abstract: There is disclosed a frictionizing composition for imparting long-term anti-slip properties to the surface of a paper product comprising an aqueous sol of colloidal silica, glycerin, and at least one agent selected from the group consisting of N-methyl pyrrolidone, N,N-dimethyl acetoacetamide, urea, sorbitol, fructose and dextrose. The composition remains fluid, even after prolonged exposure to drying conditions, and thus is readily dispersible in water for easy cleanup of residue from apparatus and the work environment.

公开(公告)号：US20020102308A1

公开(公告)日：2002-08-01

申请号：US10059635

申请日：2002-01-29

Inventor： Shifeng Bill Wei ,  Herling Uang

IPC: A61K009/14 ,  B01J013/00

CPC classification number: A61K9/2095 ,  A61K9/2086

Abstract: The invention relates to a substrate coating for the electrostatic deposition of dry powder medicaments for use in the manufacture of pharmaceutical dosage forms comprising micronized polyethylene glycol (PEG), with A molecular weight in the range of 1,000 to 20,000, and having a particle size of 1-100 nullm. The invention also relates to pharmaceutical compositions having such a substrate coating, and processes for manufacturing such pharmaceutical compositions. The invention also relates to the technology of reversing negative charge of medicaments so that they can be electrostatically deposited on a negatively charged substrate.

Abstract translation: 本发明涉及一种用于制造包含微粉化聚乙二醇（PEG）的药物剂型的干粉药物的静电沉积用基材涂层，其分子量范围为1,000至20,000，具有粒径为 1-100妈妈 本发明还涉及具有这种基底涂层的药物组合物，以及制造这种药物组合物的方法。 本发明还涉及逆向负药物的技术，使得它们可以静电沉积在带负电的基底上。

公开(公告)号：US20020035162A1

公开(公告)日：2002-03-21

申请号：US09825824

申请日：2001-04-04

Inventor： Gerard K. Newman ,  Jeffrey H. Harwell ,  Lance Lobban

IPC: B01J013/00 ,  B01J008/00 ,  B01D021/01 ,  A61L009/00 ,  C07C011/24

CPC classification number: B01J35/0026 ,  B01J21/063 ,  B01J35/002 ,  B01J35/004

Abstract: A method of enhancing oxidation of air contaminants on an ultra-low density, UV light accessible aerogel photocatalyst is provided. The method includes the steps of providing a photocatalytic reactor system broadly comprising a photocatalytic reactor cell, a UV light source, and a pump to force the contaminated air stream through the photocatalytic reactor cell. The photocatalytic reactor cell includes glass cell. A catalyst bed formed of a titanium dioxide aerogel is provided in the glass cell whereby a high fraction of the titanium dioxide aerogel is accessible to UV light and gas. The catalyst bed is exposed to UV light from the UV light source and a contaminated air stream is introduced into the photocatalytic reactor cell such that the air stream passes through the catalyst bed causing oxidation of the contaminants of the air stream.

Abstract translation: 提供了一种在超低密度紫外线可及的气凝胶光催化剂上增强空气污染物氧化的方法。 该方法包括提供广泛包含光催化反应器电池，UV光源和泵的光催化反应器系统的步骤，以迫使污染的空气流通过光催化反应器电池。 光催化反应器电池包括玻璃电池。 在玻璃电池中提供由二氧化钛气凝胶形成的催化剂床，由此可以使紫外光和气体接近高比例的二氧化钛气凝胶。 将催化剂床暴露于来自UV光源的UV光，并将污染的空气流引入光催化反应器电池中，使得空气流通过催化剂床，引起空气流的污染物的氧化。