公开(公告)号：US11267832B2

公开(公告)日：2022-03-08

申请号：US16658471

申请日：2019-10-21

申请人： The Board of Regents of the University of Texas System

发明人： Sara Chirayil ,  Veronica Clavijo Jordan ,  Andre F. Martins ,  A. Dean Sherry

IPC分类号： C07F13/00 ,  A61K9/00 ,  A61K49/10 ,  C07D213/82

摘要： In some aspects, the present disclosure provides compounds of the formula: wherein the variables are defined herein. In some aspects, the present disclosure provides methods of preparing imaging agents, compositions thereof, and methods of imaging using said imaging agents or compositions thereof.

公开(公告)号：US11214586B2

公开(公告)日：2022-01-04

申请号：US16767786

申请日：2018-08-16

申请人： SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

发明人： Keith Man Chung Wong ,  Chuangjun Liu ,  Ping Gong ,  Lihua Zhou ,  Lintao Cai

IPC分类号： C07F15/00 ,  C07F13/00 ,  A61P35/00

摘要： Through the use of a rhodamine appended chelate, a versatile strategy has been demonstrated to generate mitochondria-targeting photosensitizers via the incorporation of variety of luminescent transition metal systems. The generation of triplet excited state of rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (1O2) for use as photodynamic therapy (PDT) agent. The combination of rhodamine organic dye and luminescent transition metal centers in such hybrid systems exhibits the synergistic merits, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity for low-energy excitation in the visible region, and high photostability.

公开(公告)号：US20210347796A1

公开(公告)日：2021-11-11

申请号：US17378852

申请日：2021-07-19

申请人： Galera Labs, LLC

发明人： Jeffery L. KEENE ,  Otto F. SCHALL ,  Dennis P. RILEY

IPC分类号： C07F13/00 ,  A61K31/28 ,  A61K9/00 ,  A61K47/14 ,  A61K9/28 ,  A61K9/48 ,  A61K31/555 ,  A61K47/38 ,  A61K47/44

摘要： Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula —OC(O)X1. each of the two axial ligands has the formula —OC(═O)X1 wherein each X1 is independently substituted or unsubstituted phenyl or —C(—X2)(—X3)(—X4); each X2 is independently substituted or unsubstituted phenyl, or substituted or unsubstituted alkyl; each X3 is independently hydrogen, hydroxyl, alkyl, amino, —X5C(═O)R13 where X5 is NH or O, and R13 is C1-C18 alkyl, substituted or unsubstituted aryl or C1-C18 aralkyl, or —OR14, where R14 is C1-C18 alkyl, substituted or unsubstituted aryl or C1-C18 aralkyl, or together with X4 is (═O); and each X4 is independently hydrogen or together with X3 is (═O).

公开(公告)号：US20210317151A1

公开(公告)日：2021-10-14

申请号：US17267687

申请日：2019-08-16

申请人： CORNELL UNIVERSITY

发明人： Arthur Paden KING ,  Sierra C. MARKER ,  Robert SWANDA ,  Shu-Bing QIAN ,  Justin J. WILSON

IPC分类号： C07F13/00 ,  A61P35/00

摘要： A composition comprising the following structure: (1) wherein Re represents a rhenium ion having a +1 charge; (I) represents an uncharged bidentate ligand containing at least one ring containing a ring nitrogen atom bound to the rhenium (Re), and the bidentate ligand containing another nitrogen atom, either in a ring or not in a ring, bound to the rhenium (Re); and L1, L2, L3, and L4 are neutral ligands with at least one neutral ligand being an isonitrile ligand of the formula —CN—R, wherein R is an aliphatic or aromatic hydrocarbon group containing 1-20 carbon atoms; and X− represents a non-coordinating monovalent anion; wherein the bidentate ligand and R are optionally substituted by one or more groups selected from (i)-(xi) as further discussed above. Methods for treating a condition that benefits from ER stress induction, such as cancer, by administering the above rhenium complex are also disclosed.

公开(公告)号：US20210230513A1

公开(公告)日：2021-07-29

申请号：US17228524

申请日：2021-04-12

申请人： Henkel AG & Co. KGaA

发明人： Frank Meier ,  Mareile Job ,  Christian Kropf ,  Ulrich Pegelow

IPC分类号： C11D3/16 ,  C11D11/00 ,  C11D1/83 ,  C11D3/40 ,  C11D17/04 ,  C09B57/10 ,  C07F15/02 ,  C07F13/00 ,  C07F11/00

摘要： Catechol metal complex compounds of formula (I) are colored and can be used to give color to surfactant compositions. Detergents containing these catechol metal complex compounds do not stain the textile even after repeated use.

公开(公告)号：US11072621B2

公开(公告)日：2021-07-27

申请号：US16630902

申请日：2018-07-06

申请人： CJ CHEILJEDANG CORPORATION

发明人： Jun-Woo Kim ,  Min Kyu Kang ,  Gyeonghwan Kim ,  Il Chul Kim ,  Juun Park ,  Yong Bum Seo ,  In Sung Lee ,  Jun Young Jung ,  Je-won Hong

IPC分类号： C07F3/06 ,  A23K20/142 ,  C01F11/24 ,  C07C319/20 ,  C07C323/58 ,  C07F13/00 ,  C07F15/02 ,  C07F1/08

摘要： The present disclosure relates to a preparation method of a methionine-metal chelate, and the methionine-metal chelate, which is prepared by first reacting Ca(OH)2 and methionine and adding metal chloride salts, can be used as feeds and feed additives.

公开(公告)号：US11021450B2

公开(公告)日：2021-06-01

申请号：US16820052

申请日：2020-03-16

申请人： The Johns Hopkins University

发明人： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07D257/02 ,  C07D311/20 ,  A61K51/04 ,  C07D311/82 ,  C07D213/04 ,  C07D209/14 ,  C07D249/04 ,  C07F13/00 ,  C07D209/12 ,  C07D255/02 ,  A61K49/00 ,  G01N33/50 ,  C07D311/14 ,  C07F5/02 ,  C07D209/24

摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

公开(公告)号：US11005108B2

公开(公告)日：2021-05-11

申请号：US15236963

申请日：2016-08-15

申请人： Massachusetts Institute of Technology

发明人： Yogesh Surendranath ,  Tomohiro Fukushima ,  Matthew E. O'Reilly ,  Seokjoon Oh ,  Alexander T. Murray ,  Corey Jarin Kaminsky ,  Sterling Ben Chu ,  Megan N. Jackson

IPC分类号： C07F15/00 ,  H01M4/90 ,  C07F13/00 ,  H01M8/083

摘要： Disclosed are surface immobilized (electro)catalysts that may be prepared by a condensation reaction that generates an aromatic unit that is robust to acid and base and elevated temperatures. Among their many desirable characteristics, the catalysts are far less prone to the bimolecular deactivation pathways commonly observed for homogeneous catalysts, and may be used in solvents with a range of polarities and dielectric strengths. The catalysts are suitable for a wide array of thermal catalytic reactions (polymerization, oxidation, hydrogenation, cross-coupling etc.) and as anodes and/or cathodes in fuel cells, electrolyzers, and in batteries and supercapacitors.

公开(公告)号：US20210070686A1

公开(公告)日：2021-03-11

申请号：US16955618

申请日：2018-12-19

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： Markus E. Hirschberg ,  Klaus Hintzer ,  William M. Lamanna ,  Sean M. Smith ,  Gerd-Volker Röschenthaler ,  Romana Pajkert ,  Sergey N. Tverdomed

IPC分类号： C07C51/31 ,  C07F13/00 ,  C07C41/02

摘要： A method of making a polyfunctional polyfluorinated compound includes combining first components that include a polyfluorinated cyclic compound having 4 to 7 ring carbon atoms and at least one of osmium tetroxide, ruthenium tetroxide or a precursor thereof and forming a polyfluorinated dicarboxylic acid. Two of the ring carbon atoms of the polyfluorinated cyclic compound form a double bond or an epoxide. The precursor reacts with an oxidant to form ruthenium tetroxide. Methods also include converting the polyfluorinated dicarboxylic acid to a polyfluorinated dicarboxylic acid halide and converting the polyfluorinated dicarboxylic acid halide to other polyfunctional polyfluorinated compounds.

公开(公告)号：US10858381B2

公开(公告)日：2020-12-08

申请号：US16513064

申请日：2019-07-16

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Xinyan Cui ,  Noah Snyder ,  Kasey Catt ,  James Eles

IPC分类号： C07F13/00 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  C07D487/22 ,  C07F3/02 ,  C07F15/02 ,  A61L27/28 ,  A61B5/04 ,  A61B17/68 ,  A61C8/00 ,  A61F2/24 ,  A61F2/82 ,  A61L26/00 ,  A61L27/52 ,  A61M25/00 ,  A61N1/36 ,  C08K5/3432 ,  C09D5/16 ,  A61N1/362 ,  A61B17/00

摘要： Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.