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公开(公告)号：US20210070877A1
公开(公告)日：2021-03-11
申请号：US17077376
申请日：2020-10-22
Applicant: GENMAB A/S
Inventor： David SATIJN , Esther C. W. BREIJ , Bart E. C. G. DE GOEIJ , Kristel KEMPER , Patrick ENGELBERTS , Edward N. VAN DEN BRINK , Rik RADEMAKER , Dennis VERZIJL , Sjeng HORBACH , Paul PARREN
Abstract: The present invention relates to antibodies binding to 5T4, including bispecific antibodies binding to 5T4 and CD3. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
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公开(公告)号：US20200332022A1
公开(公告)日：2020-10-22
申请号：US16783720
申请日：2020-02-06
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Joost J. NEIJSSEN , Edward Norbert VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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公开(公告)号：US10544220B2
公开(公告)日：2020-01-28
申请号：US15541594
申请日：2016-01-08
Applicant: GENMAB A/S
Inventor： Patrick Engelberts , Esther Breij , Rik Rademaker , Isil Altintas , David Satijn , Sandra Verploegen , Riemke Van Dijkhuizen Radersma , Edward Van Den Brink , Janine Schuurman , Paul Parren
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K39/00
Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.
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公开(公告)号：US10465006B2
公开(公告)日：2019-11-05
申请号：US14902757
申请日：2014-07-04
Applicant: GENMAB
Inventor： Edward Van Den Brink , Joost J. Neijssen , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Paul Parren
Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.
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公开(公告)号：US10351629B2
公开(公告)日：2019-07-16
申请号：US15072983
申请日：2016-03-17
Applicant: GENMAB A/S
Inventor： Janine Schuurman , Tom Vink , Jan Van De Winkel , Aran Frank Labrijn , Paul Parren , Willem Karel Bleeker , Frank Beurskens , Patrick Van Berkel
Abstract: The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
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Patent Agency Ranking
公开(公告)号：US20180022816A1
公开(公告)日：2018-01-25
申请号：US15627921
申请日：2017-06-20
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Edward N. VAN DEN BRINK , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD, D.M.Sc. , David SATIJN , Jan VAN DE WINKEL , Paul PARREN
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US09540433B2
公开(公告)日：2017-01-10
申请号：US13982959
申请日：2012-02-01
Applicant: Sandra Verploegen , Marije Overdijk , Riemke Van Dijkhuizen , Willem Karel Bleeker , Patrick Van Berkel , Paul Parren , Steen Lisby
Inventor： Sandra Verploegen , Marije Overdijk , Riemke Van Dijkhuizen , Willem Karel Bleeker , Patrick Van Berkel , Paul Parren , Steen Lisby
IPC: A61K39/395 , C07K16/28 , C07K16/30 , C07K16/42 , C07K16/18 , A61K47/48 , A61K51/10 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/16 , A61K38/19 , A61K45/06 , A61K39/00
CPC classification number: A61K39/39541 , A61K31/7088 , A61K35/17 , A61K35/76 , A61K38/162 , A61K38/19 , A61K39/39533 , A61K39/39566 , A61K45/06 , A61K47/6849 , A61K51/1027 , A61K2039/505 , A61K2121/00 , C07K16/18 , C07K16/2833 , C07K2317/21 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92 , Y02A50/472
Abstract: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.
Abstract translation: 公开了与人CD74和相关抗体 - 药物偶联物结合的分离的人单克隆抗体。 还公开了包含抗体或抗体 - 药物偶联物的药物组合物，以及使用抗体和/或抗体 - 药物偶联物的治疗和诊断方法。
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公开(公告)号：US09492565B2
公开(公告)日：2016-11-15
申请号：US14854613
申请日：2015-09-15
Applicant: GENMAB A/S
Inventor： David Satijn , Sandra Verploegen , Wim Bleeker , Steen Lisby , Jan Van De Winkel , Patrick Van Berkel , Paul Parren
IPC: A61K39/395 , A61K47/48 , C07K16/36 , A61K45/06 , C07K16/30
CPC classification number: A61K47/48561 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/30 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.
Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物共轭物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。
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公开(公告)号：US09068011B2
公开(公告)日：2015-06-30
申请号：US13583743
申请日：2011-03-10
Applicant: Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
Inventor： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
CPC classification number: C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
Abstract translation: 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20140170148A1
公开(公告)日：2014-06-19
申请号：US14112848
申请日：2012-04-20
Applicant: Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
Inventor： Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
IPC: C07K16/32 , A61K45/06 , A61K39/395 , A61K51/10 , A61K47/48
CPC classification number: C07K16/32 , A61K45/06 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6813 , A61K47/6825 , A61K47/6827 , A61K47/6829 , A61K47/6855 , A61K47/6879 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
Abstract translation: 公开了包含与人表皮生长因子受体2（HER2）的两个不同表位结合的抗原结合区的双特异性抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和制备和使用抗体的方法。
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