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公开(公告)号：US20130216548A1
公开(公告)日：2013-08-22
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
IPC分类号： C07K16/40 , A61K45/06 , A61K39/395
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US09068011B2
公开(公告)日：2015-06-30
申请号：US13583743
申请日：2011-03-10
申请人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
发明人： Joost J. Neijssen , Bart De Goeij , Edward Norbert Van Den Brink , Aran Frank Labrijn , Rene Hoet , Janine Schuurman , Paul Parren , Jan Van De Winkel
CPC分类号： C07K16/3076 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/5748 , G01N2333/912
摘要： Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了结合人c-Met，肝细胞生长因子受体以及相关的基于抗体的组合物和分子的分离的单克隆抗体。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US20130189271A1
公开(公告)日：2013-07-25
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了与人表皮生长因子受体2（HER2）结合的分离的单克隆抗体以及相关的抗体基组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US09862769B2
公开(公告)日：2018-01-09
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce Meesters , Janine Schuurman , Edward N. Van Den Brink
IPC分类号： A61K39/395 , C07K16/00 , C07K16/28 , C07K16/32 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US09714294B2
公开(公告)日：2017-07-25
申请号：US13700246
申请日：2011-05-27
申请人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
发明人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC分类号： C07K16/30 , A61K39/395 , C07K16/32 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20130171148A1
公开(公告)日：2013-07-04
申请号：US13700246
申请日：2011-05-27
申请人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
发明人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了与人表皮生长因子受体2（HER2）结合的分离的单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
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公开(公告)号：US09150658B2
公开(公告)日：2015-10-06
申请号：US13133811
申请日：2009-12-09
申请人： Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
发明人： Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
IPC分类号： C07K16/36 , A61K39/395
CPC分类号： C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20110300156A1
公开(公告)日：2011-12-08
申请号：US13133811
申请日：2009-12-09
申请人： Sandra Verploegen , David P.E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
发明人： Sandra Verploegen , David P.E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
IPC分类号： A61K39/395 , C12P21/00 , C12N15/63 , A61P35/00 , C12N1/15 , C12N1/19 , C12N1/21 , G01N33/573 , C07K16/40 , C12N5/10
CPC分类号： C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US08106168B2
公开(公告)日：2012-01-31
申请号：US12776195
申请日：2010-05-07
申请人： Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人： Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要： Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译： 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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公开(公告)号：US20080254021A1
公开(公告)日：2008-10-16
申请号：US12020140
申请日：2008-01-25
申请人： Simon E. Hufton , Rene Hoet , Henk Pieters
发明人： Simon E. Hufton , Rene Hoet , Henk Pieters
IPC分类号： A61K39/395 , C12P21/08 , C07H21/00 , C12N5/06 , G01N33/53 , A61P19/02 , A61P35/00 , A61P17/06
CPC分类号： C07K16/2863 , C07K16/005 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/00
摘要： Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.
摘要翻译： Tie1是包含跨膜结构域的受体酪氨酸激酶蛋白。 Tie1存在于内皮细胞上。 本公开描述了结合Tie1的抗体，包括抑制内皮细胞活性的抗体。
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