公开(公告)号：US10519500B2

公开(公告)日：2019-12-31

申请号：US15600957

申请日：2017-05-22

Applicant: Southern Medical University ,  Macau University of Science and Technology

Inventor： Jin-Xiang Chen ,  Bao-Ping Xie ,  Gui-Hua Qiu ,  Pei-Pei Hu ,  Zhen Liang ,  Ye-Mei Liang ,  Bin Sun ,  Li-Ping Bai ,  Zhi-Hong Jiang

IPC: C12Q1/68 ,  C08G79/00 ,  C12Q1/6876

Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.

公开(公告)号：US10354398B2

公开(公告)日：2019-07-16

申请号：US15367158

申请日：2016-12-01

Applicant: Macau University of Science and Technology

Inventor： Zhanchuan Cai ,  Wei Cao

IPC: G06K9/00 ,  G06T7/40 ,  G06K9/46

Abstract: A method executed by a computer system to construct an omnidirectional roughness (OR) map of a lunar crater based on a data set of a digital elevation model (DEM) of surface textures of the lunar crater is provided. The method includes setting a center and a first point of the data set, selecting a moving window, utilizing a one point-to-point step when the moving window slides over the DEM, calculating a morphological surface roughness (MSR) that detects a vertical roughness of the lunar crater, calculating a topographic frequency coefficient (TFC) that detects a horizontal roughness of the lunar crater, constructing the OR map, and displaying the OR map to show a surface roughness of the lunar crater.

公开(公告)号：US10346565B2

公开(公告)日：2019-07-09

申请号：US15364239

申请日：2016-11-29

Applicant: Macau University of Science and Technology

Inventor： Zhanchuan Cai

IPC: G06F17/50

Abstract: A computer system executes hierarchical MK splines approximation for lunar brightness temperature (TB) data approximation. The computer system constructs a TB model map by generating a final approximation function for constructing an interpolated surface that approximates the TB data set obtained by lunar probe. The method includes executing MK splines approximation to the TB data set with a hierarchy of control lattice from coarsest lattice to densest lattice to iteratively obtain approximation functions. The TB model map is constructed by generating a final approximation function to construct the interpolated surface.

公开(公告)号：US10346214B2

公开(公告)日：2019-07-09

申请号：US15649634

申请日：2017-07-13

Applicant: Macau University of Science and Technology

Inventor： Zhiwu Li ,  Oussama Karoui ,  Naiqi Wu ,  Mohamed Khalgui

IPC: G06F9/46 ,  G06F9/50 ,  G06F9/48

Abstract: Given a sequential resource allocation system (RAS) topology structure, a state space, called an impulse state space, corresponding to the impulse response of a linear time-invariant system (LTS), is computed by small enough configuration of the considered RAS. Given an initial resource configuration of a RAS which corresponds to an input of an LTS, a complete state enumeration can be obtained by defining the convolution of this configuration with the pre-computed impulse state space. One example embodiment reduces central processing unit (CPU) time to process instructions that compute a target state space of a RAS includes constructing an initial RAS and an initial state space, and extending the initial state space iteratively under a target resource configuration.

公开(公告)号：US20190202802A1

公开(公告)日：2019-07-04

申请号：US15861641

申请日：2018-01-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong JIANG ,  Li-Ping BAI ,  Xiaobo ZHOU ,  Kam Wai Vincent WONG ,  Zhiyuan ZHENG ,  Yuen Kwan Betty LAW

IPC: C07D401/12 ,  A61P35/00 ,  C07D413/14

CPC classification number: C07D401/12 ,  A61P35/00 ,  C07D413/14

Abstract: One embodiment provides a compound of Formula I that activates autophagy, a pharmaceutical composition and use thereof:

公开(公告)号：US20190178885A1

公开(公告)日：2019-06-13

申请号：US16281122

申请日：2019-02-21

Applicant: Macau University of Science and Technology

Inventor： Liang LIU ,  Jing-Rong WANG ,  Weina GAO ,  Leefong YAU ,  Hao HUANG ,  Qiong MENG ,  Tiantian TONG ,  Zhi-Hong JIANG

IPC: G01N33/564 ,  B01L3/00 ,  G01N1/40 ,  G01N30/08 ,  G01N30/60 ,  G01N30/72

Abstract: The present invention discloses a method of determining the presence of autoimmune disease with the use of glycan biomarkers. A method of improving the detection sensitivity of trace glycans from a mixture of glycans and a microfluidic chip therefor are also disclosed.

公开(公告)号：US10278966B2

公开(公告)日：2019-05-07

申请号：US15142407

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K31/4745 ,  A61K36/27

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

公开(公告)号：US20190070170A1

公开(公告)日：2019-03-07

申请号：US15695304

申请日：2017-09-05

Applicant: Macau University of Science and Technology

Inventor： Hua Zhou ,  Jian-Xin Liu ,  Jin-Fang Luo ,  Chun-Song Chen ,  Elaine Lai-Han Leung ,  Liang Liu

IPC: A61K31/485 ,  G01N33/573 ,  C12Q1/68

Abstract: A method of selectively inhibiting the overexpression of mPGES-1 in a subject in need thereof includes a step of administering an effective amount of a selective mPGES-1 inhibitor or a salt thereof to the subject. A method of treating a subject suffering from a disease associated with an overexpression of mPGES-1 and having a risk of cardiovascular event includes the step of administering an effective amount of a selective mPGES-1 inhibitor to the subject.

公开(公告)号：US10192642B2

公开(公告)日：2019-01-29

申请号：US15150639

申请日：2016-05-10

Applicant: Macau University of Science and Technology

Inventor： Yong Liang ,  Hua Chai ,  Xiao-Ying Liu

IPC: G06F19/00 ,  G06F19/12 ,  G16H50/50

Abstract: A system and a method for determining an association of at least one biological feature with a medical condition, in particularly, but not exclusively, a system and a method of determining an association of at least one biological feature in form of a gene expression with cancer or a subtype of cancer that can include the generation of a simplified protein-protein interaction network based on processed biological data. The system and respective method is especially suitable for analysis of high dimensional and low sample size biological datasets such as in cancer research.

公开(公告)号：US20180305300A1

公开(公告)日：2018-10-25

申请号：US15495949

申请日：2017-04-24

Applicant: Macau University of Science and Technology

Inventor： Guo-Yuan ZHU ,  Zhi-Hong JIANG ,  Ji YANG ,  Xiao-Jun YAO ,  Xin LIU ,  Jing FU ,  Li-Ping BAI ,  Liang LIU

IPC: C07C237/26 ,  C07C231/24

CPC classification number: A61K31/00 ,  A61P25/28 ,  C07C235/82 ,  C07C2603/97

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.