Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors
    191.
    发明申请
    Pyrazolo [3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors 失效
    吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途

    公开(公告)号:US20060252790A1

    公开(公告)日:2006-11-09

    申请号:US10540371

    申请日:2003-12-19

    CPC classification number: C07D471/04

    Abstract: The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl or —(CH2)2OH; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3a is a hydrogen atom (H) or C1-3alkyl; R3 is optionally substituted branched C3-6alkyl, optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, optionally substituted phenyl, or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc): in which n1 and n2 independently are 1 or 2; and Y is O, S, SO2, or NR4; and wherein Het is of sub-formula (i), (ii), (iii), (iv) or (v): The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.

    Abstract translation: 本发明涉及式(I)化合物或其盐:其中:R 1是C 1-4烷基,C 1-3烷基, 氟代烷基或 - (CH 2 CH 2)2 OH; R 2是氢原子(H),甲基或C 1氟代烷基; R 3a是氢原子(H)或C 1-3烷基; R 3是任选取代的支链C 3-6 - 烷基,任选取代的C 3-8环烷基,任选取代的单不饱和-C 2 独立为1或2; Y是O,S,SO 2或NR 4; 并且其中Het为亚式(i),(ii),(iii),(iv)或(v):所述化合物是磷酸二酯酶(PDE)抑制剂,特别是PDE4抑制剂。 还提供了式(I)化合物或其药学上可接受的盐在制备用于治疗和/或预防哺乳动物例如人的炎性和/或过敏性疾病的药物中的用途, 例如慢性阻塞性肺疾病(COPD),哮喘或过敏性鼻炎。

    Method and apparatus for controlling transition rates on adjacent interconnects
    192.
    发明申请
    Method and apparatus for controlling transition rates on adjacent interconnects 有权
    用于控制相邻互连上的转换速率的方法和装置

    公开(公告)号:US20060226882A1

    公开(公告)日:2006-10-12

    申请号:US11094710

    申请日:2005-03-30

    CPC classification number: H03K19/00346 H03K17/164 H03K19/00361

    Abstract: A method, and apparatus are provided for controlling transition rates on adjacent interconnects in an electronic chip design. Each interconnect includes a first inverter that receives a net input and provides an initial inverted output and a second inverter coupled to the first inverter receiving the initial inverted output and providing a net output. A first compensating logic transistor stack coupled to the first inverter and a first adjacent net receives the initial inverted output and the first adjacent net input for selectively providing conductive paths. A second compensating logic transistor stack coupled to the first inverter and a second adjacent net receiving the initial inverted output and the second adjacent net input for selectively providing conductive paths.

    Abstract translation: 提供了一种用于控制电子芯片设计中相邻互连上的转换速率的方法和装置。 每个互连包括接收净输入并提供初始反相输出的第一反相器和耦合到接收初始反相输出并提供净输出的第一反相器的第二反相器。 耦合到第一反相器和第一相邻网的第一补偿逻辑晶体管堆栈接收初始反相输出和第一相邻净输入,用于选择性地提供导电路径。 耦合到第一反相器的第二补偿逻辑晶体管堆叠和接收初始反相输出的第二相邻网络和用于选择性地提供导电路径的第二相邻网络输入。

    Method and apparatus for managing information related to storage activities of data storage systems
    194.
    发明授权
    Method and apparatus for managing information related to storage activities of data storage systems 有权
    用于管理与数据存储系统的存储活动有关的信息的方法和装置

    公开(公告)号:US07054892B1

    公开(公告)日:2006-05-30

    申请号:US09471869

    申请日:1999-12-23

    Abstract: Methods and apparatus for managing information related to backup storage activities of data storage systems. In a computer system having one or more independent backup data storage systems coupled to each other and each serving one or more clients, a user may obtain information related to backup activities of any of the backup storage systems from a single location. Through a user interface associated with any of the backup storage systems, or through a stand alone user interface, a user may manage (e.g., organize, display, print) information related to backup activities of any or all of the backup storage systems. System administrators can design and store a variety of report formats that may be utilized by any user to display or print various parameters associated with backup activities in a particular manner. Report formats may be edited by users, and displayed parameters may be dynamically updated to provide for active monitoring of one or more backup storage systems. Additionally, periodic backup activity reports can be generated and automatically sent to designated locations, for example to one or more printers and/or to one or more designated recipients via E-mail.

    Abstract translation: 用于管理与数据存储系统的备份存储活动有关的信息的方法和装置。 在具有彼此耦合并且每个服务于一个或多个客户端的一个或多个独立备份数据存储系统的计算机系统中,用户可以从单个位置获得与任何备份存储系统的备份活动相关的信息。 通过与任何备份存储系统相关联的用户界面,或通过独立的用户界面,用户可以管理(例如,组织,显示,打印)与任何或所有备份存储系统的备份活动相关的信息。 系统管理员可以设计和存储各种报告格式,任何用户可以利用它们以特定的方式显示或打印与备份活动相关的各种参数。 报告格式可以由用户编辑,并且显示的参数可以被动态地更新以提供一个或多个备份存储系统的主动监视。 此外,定期备份活动报告可以生成并自动发送到指定位置,例如通过电子邮件发送到一个或多个打印机和/或一个或多个指定的收件人。

    Systems and methods for handling information from wireless nodes, including nodes for communication with aircraft
    195.
    发明申请
    Systems and methods for handling information from wireless nodes, including nodes for communication with aircraft 有权
    用于处理来自无线节点的信息的系统和方法,包括用于与飞机通信的节点

    公开(公告)号:US20060094417A1

    公开(公告)日:2006-05-04

    申请号:US10976662

    申请日:2004-10-29

    Abstract: Systems and methods for handling information from wireless nodes, including nodes for communication with aircraft, are disclosed. A system in accordance with one aspect of the invention includes a sensor configured to sense information corresponding to a characteristic of a wireless node. The wireless node can be one of a plurality of wireless nodes configured to transmit and receive wireless signals. The wireless nodes can also be linked to a non-wireless network portion. The system can further include a transmitter configured to transmit the information via the network, and a receiver operatively coupled to the transmitter to receive the information via the network. Accordingly, the system can be used to automatically identify and track diagnostic information corresponding to the state of one or more wireless nodes.

    Abstract translation: 公开了用于处理来自无线节点(包括用于与飞机通信的节点)的信息的系统和方法。 根据本发明的一个方面的系统包括被配置为感测对应于无线节点的特性的信息的传感器。 无线节点可以是被配置为发送和接收无线信号的多个无线节点之一。 无线节点还可以链接到非无线网络部分。 该系统还可以包括配置成经由网络传输信息的发射机,以及可操作地耦合到发射机的接收机,经由网络接收信息。 因此,该系统可用于自动识别和跟踪与一个或多个无线节点的状态相对应的诊断信息。

    Storage device for CD's, DVD's, CD-ROM's and similar media
    196.
    发明申请
    Storage device for CD's, DVD's, CD-ROM's and similar media 有权
    CD,DVD,CD-ROM和类似媒体的存储设备

    公开(公告)号:US20060042974A1

    公开(公告)日:2006-03-02

    申请号:US11173517

    申请日:2005-07-02

    Applicant: David Allen

    Inventor: David Allen

    CPC classification number: G11B33/0422

    Abstract: A case, more specifically an openable and closeable case for the storage, shipment and retail display of CDs, DVD's, CD-ROM's or similar devices in disk form. The case includes a one-piece case with grooves on its interior sides, which suspend the stored disk in the case, and a rotating closure, which secures a disk within the case. The case is opened and closed through the use of grooves on each exterior end of the rotating closure or through the use of grooves running the length of the closure. A slot with grooves matching the grooves on the case guide disks through the slot and into the case. Nodes on either side of the cylinder hold it to the case via indentations, or “dimples” that snap the cylinder into open and closed positions.

    Abstract translation: 一种情况,更具体地说是用于存储,装运和零售显示CD,DVD,CD-ROM或类似磁盘形式的设备的情况。 壳体包括在其内侧具有凹槽的一体式壳体,其将存储的盘悬挂在壳体中,以及将盘固定在壳体内的旋转闭合件。 通过使用旋转封闭件的每个外端上的凹槽或通过使用延伸封闭件的长度的凹槽来打开和关闭外壳。 具有凹槽的凹槽,其具有与壳体引导盘上的凹槽匹配通过狭槽并进入壳体的凹槽。 气缸两侧的节点通过压痕将其保持在壳体上,或者将气缸卡入打开和关闭位置的“凹坑”。

    Systems and methods for small element trapping
    197.
    发明申请
    Systems and methods for small element trapping 审中-公开
    小元件捕获的系统和方法

    公开(公告)号:US20060033961A1

    公开(公告)日:2006-02-16

    申请号:US11253506

    申请日:2005-10-18

    Applicant: David Allen

    Inventor: David Allen

    CPC classification number: H04N1/58

    Abstract: Various systems and methods for performing trapping on media productions of mixed object size. As just one example, a method is disclosed that includes providing a default trapping approach and a modified small element trapping approach. It is determined whether an object is a small element, and based on identification of a small element, one of the default trapping approach, the modified small element trapping approach, and a non-trapping approach is applied to the small element.

    Abstract translation: 用于在混合物体尺寸的介质制品上进行捕获的各种系统和方法。 作为仅一个示例,公开了一种包括提供默认捕获方法和修改的小元素捕获方法的方法。 确定对象是否是小元素,并且基于小元素的识别,将小元素应用于默认捕获方法之一,修改的小元素捕获方法和非捕获方法。

    Apparatus and method for facilitating encryption and decryption operations over an email server using an unsupported protocol
    198.
    发明申请
    Apparatus and method for facilitating encryption and decryption operations over an email server using an unsupported protocol 有权
    用于通过使用不支持协议的电子邮件服务器来促进加密和解密操作的装置和方法

    公开(公告)号:US20060031670A1

    公开(公告)日:2006-02-09

    申请号:US11176590

    申请日:2005-07-06

    Abstract: The invention includes a computer readable medium storing executable instructions to enroll a user with a secure email support facility. The computer readable medium includes executable instructions to send an enrollment message, supply a registration response, and confirm the registration response. An authentication email is also sent. A client identifies the authentication email. Authentication information within the authentication email is decrypted. The authentication information is used to authenticate the client and subsequently obtain access to a secure email support facility.

    Abstract translation: 本发明包括一种存储用于向用户注册安全电子邮件支持设施的可执行指令的计算机可读介质。 计算机可读介质包括发送注册消息,提供注册响应以及确认注册响应的可执行指令。 还发送验证电子邮件。 客户端识别身份验证电子邮件。 验证电子邮件中的认证信息被解密。 认证信息用于认证客户端,随后获得对安全电子邮件支持设施的访问。

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