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199 条记录 (耗时 0.054 秒)

    3-Amino-1-phenyl-1h,5h,-benzo-2,4-thiazepines
    194.
    发明授权
    3-Amino-1-phenyl-1h,5h,-benzo-2,4-thiazepines 失效
    3-氨基-1-苯基-1H，5H，-BENZO-2,4-THIAZEPINES

    公开(公告)号：US4045572A

    公开(公告)日：1977-08-30

    申请号：US690210

    申请日：1976-05-26

    申请人： John Bernard Bream

    发明人： John Bernard Bream

    IPC分类号： A61K31/554 ,  C07C335/12 ,  C07D281/02

    CPC分类号： C07C335/12 ,  C07D281/02 ,  C10G9/00 ,  C10G9/38 ,  Y10S514/821

    摘要： This invention provides new compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl,R.sub.3 is hydrogen, lower alkyl, lower hydroxyalkyl, or phenylalkyl of 7 to 10 carbon atoms, wherein the phenyl ring is unsubstituted or mono-substituted, or independently di-substituted, by halogen, lower alkyl, lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino, andR.sub.4 is hydrogen, lower alkyl or lower hydroxyalkyl,Useful as anti-arrhythmics and anti-depressants.

    5-Heterocyclicalkyl-2-aryl-3-halo 1,5-benzothiazepin-4(5H)-ones
    196.
    发明授权
    5-Heterocyclicalkyl-2-aryl-3-halo 1,5-benzothiazepin-4(5H)-ones 失效
    5-杂环烷基-2-芳基-3-卤代1,5-苯并硫氮杂-4（5H） - 酮

    公开(公告)号：US3983106A

    公开(公告)日：1976-09-28

    申请号：US592966

    申请日：1975-07-03

    申请人： John Krapcho ,  Chester F. Turk

    发明人： John Krapcho ,  Chester F. Turk

    IPC分类号： C07D281/10 ,  C07D281/02

    CPC分类号： C07D281/10

    摘要： Novel benzothiazepines having the structure ##SPC1##The pharmaceutically acceptable salts thereof, the quaternary ammonium salts thereof, and the 1-oxide and 1,1-dioxide derivatives thereof; wherein R.sub.1 is phenyl or substituted phenyl; R.sub.2 is chlorine or bromine; R.sub.3 is hydrogen, alkyl, alkoxy, halogen, or trifluoromethyl; n is 2, 3, or 4; m is 0, 1 or 2, A is CH--R.sub.4, N--R.sub.5 or oxygen, R.sub.4 is hydrogen or alkyl, and R.sub.5 is hydrogen, alkyl, monohydroxyalkyl, phenyl, or substituted phenyl, provided that when m is 0 or 2, A is CH--R.sub.4 ; have useful pharmacological activity.

    摘要翻译： 具有其药学上可接受的盐的结构的新型苯并硫氮杂，其季铵盐及其1-氧化物和1,1-二氧化物衍生物; 其中R1是苯基或取代的苯基; R2是氯或溴; R3是氢，烷基，烷氧基，卤素或三氟甲基; n为2,3或4; m为0,1或2，A为CH-R4，N-R5或氧，R4为氢或烷基，R5为氢，烷基，单羟基烷基，苯基或取代的苯基，条件是当m为0或2时， A是CH-R4; 具有有用的药理活性。

    5-[(Substituted amino)alkyl]-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones
    197.
    发明授权
    5-[(Substituted amino)alkyl]-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones 失效
    5- {8（取代的氨基）烷基{9-2-芳基-3-卤代-1,5-苯并硫氮杂-4（5H） - 酮

    公开(公告)号：US3948889A

    公开(公告)日：1976-04-06

    申请号：US545459

    申请日：1975-01-30

    申请人： John Krapcho ,  Chester Frank Turk

    发明人： John Krapcho ,  Chester Frank Turk

    IPC分类号： C07D281/10 ,  C07D281/02

    CPC分类号： C07D281/10

    摘要： Benzothiazepines having the formula: ##SPC1##Wherein R.sub.1 is phenyl or substituted phenyl wherein the substituent is selected from the group consisting of alkyl, alkoxy, halogen, trifluoromethyl or alkyl ##EQU1## R.sub.2 is chlorine or bromine; and R.sub.5 is hydrogen, alkyl, alkoxy, halogen or trifluoromethyl; and wherein the terms alkyl and alkoxy, in each instance employed, refer to groups having 1 to 6 carbon atoms. These compounds are useful as intermediates in the preparation of the claimed pharmaceutically active compounds of Ser. No. 462,266, filed Apr. 19, 1974, now U.S. Pat. No. 3,895,006.

    摘要翻译： 具有下式的苯并硫氮杂