公开(公告)号：US10919841B2

公开(公告)日：2021-02-16

申请号：US15388770

申请日：2016-12-22

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Bruce Edward Blough ,  Philip Abraham

IPC: C07C225/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C225/18

Abstract: The invention provides bupropion analogue compounds capable of inhibiting the reuptake of one or more monoamines. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin. Such compounds may be used to treat conditions that are responsive to inhibition of the reuptake of monoamines, including addiction, depression, and obesity.

公开(公告)号：US20200297636A1

公开(公告)日：2020-09-24

申请号：US16650965

申请日：2018-10-11

Applicant: Research Triangle Institute

Inventor： Elliott Richard PAULI ,  Hemant N. JOSHI ,  Anvit S. VASAVADA

IPC: A61K9/16 ,  A61K31/4706 ,  A61K9/48

Abstract: Water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate in powder or granule form are provided that allow for ease of preparation of measured-dose, liquid suspensions that are palatable and suitable for pediatric administration. The compositions in granular or powder form are efficiently dissolvable in water and can be provided encapsulated within a two-piece releasable hard capsule or a packet or pouch for easy release. An ion-pairing agent is present in the formulation of the composition that masks the bitter taste of the hydroxychloroquine sulfate, significantly reducing the need for addition of a sweetening agent. Methods are provided for preparing the water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate and for preparing palatable weight-based pediatric doses.

公开(公告)号：US10767210B2

公开(公告)日：2020-09-08

申请号：US16455067

申请日：2019-06-27

Applicant: Research Triangle Institute

Inventor： David S. Ensor ,  Howard Jerome Walls ,  Karin K. Foarde ,  Susanne Vera Hering ,  Steven Russel Spielman

IPC: C12Q1/24

Abstract: An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection medium downstream from the moisture exchange device and configured to collect the bioparticles. The method includes delivering bioparticles in a gas stream, humidifying or dehumidifying the bioparticles in the gas stream by transport of water across a partition member and into a vapor phase of the gas stream, and collecting the bioparticles by a collection medium.

公开(公告)号：US20200261846A1

公开(公告)日：2020-08-20

申请号：US16792246

申请日：2020-02-16

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Paul David Mobley ,  Shaojun James Zhou

IPC: B01D53/78 ,  B01D53/84 ,  B01D53/62 ,  B01D53/96

Abstract: A gas-liquid contacting apparatus and method are described, in which at least one rotor assembly including packing is arranged in a contacting chamber containing at least one stator assembly including at least one heat exchanger arranged to thermally modulate the gas-liquid contacting so that each stator assembly is operatively arranged with each stator assembly to provide gas-liquid contacting at temperatures effective for mass exchange between the gas and liquid. The rotor and stator assemblies may be of annular shape, or may be of disk shape in a stacked array of rotor assemblies alternating with stator assemblies. Such apparatus and method are usefully employed for CO2 capture from CO2-containing flue gases such as combustion effluents from power generation plants.

公开(公告)号：US20200035373A1

公开(公告)日：2020-01-30

申请号：US16580311

申请日：2019-09-24

Applicant: Research Triangle Institute

Inventor： Nicholas Guy Baldasaro

IPC: G21G1/06

Abstract: An apparatus for use with a neutron source for producing reaction-product nuclei from reactant nuclei includes a plurality of reactant nuclei and a plurality of moderating nuclei. The reactant nuclei and the moderating nuclei are configured to increase the probability of neutron capture by reactant nuclei to achieve enhanced ratios of neutron capture by reactant nuclei to neutron source neutron production. Moderating nuclei and neutron reflection are used to minimize neutron leakage. Temperature control, including cryogenic temperature control, may be used to enhance the rate or probability of reactant nuclei neutron capture. The reactant nuclei may include molybdenum-98 and reaction-product nuclei may include technetium-99m.

公开(公告)号：US20200017778A1

公开(公告)日：2020-01-16

申请号：US16506345

申请日：2019-07-09

Applicant: Research Triangle Institute

Inventor： Ofei D. Mante ,  Mustapha Soukri ,  Samuel J. Thompson ,  David C. Dayton

IPC: C10G65/12 ,  C10G3/00 ,  C10G69/04

Abstract: A process for selectively recovering a phenolic compound from feedstock comprising bio-crude and/or bio-oil is described. The recovery efficiency of the selected phenolic compound is greater than 70 wt % and the purity of the recovered selected phenolic compound is higher than 80 wt %. The process comprises distilling the feedstock to isolate the selected phenolic compound in a first distillate fraction comprising the selected phenolic compound, concentrating the selected phenolic compound from the first distillate fraction in a concentrated mixture, and purifying the concentrated mixture to recover the selected phenolic compound.

公开(公告)号：US20190352305A1

公开(公告)日：2019-11-21

申请号：US16472155

申请日：2017-12-20

Applicant: Research Triangle Institute

Inventor： Rangan Maitra ,  Robert W. Wiethe ,  Yanan Zhang ,  George S. Amato

IPC: C07D473/34 ,  C07D471/10

Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).

公开(公告)号：US20190352177A1

公开(公告)日：2019-11-21

申请号：US16525116

申请日：2019-07-29

Applicant: Research Triangle Institute

Inventor： David L. Denton ,  Raghubir P. Gupta ,  Brian S. Turk ,  Vijay Gupta ,  Himanshu Paliwal

IPC: C01B3/16 ,  C10L3/10 ,  C01B3/56 ,  C01B17/74 ,  C01B17/04 ,  C01B3/52 ,  B01D53/48 ,  B01D53/62 ,  B01D53/14 ,  B01D53/83 ,  B01D53/96 ,  B01J20/34 ,  C10K1/00 ,  C10K1/10 ,  B01J19/00 ,  C10K1/20 ,  C10K1/32 ,  B01D53/52 ,  C10K3/04 ,  B01J7/02

Abstract: Acid gas compounds are removed from a process gas such as, for example, syngas or natural gas, by flowing a feed gas into a desulfurization unit to remove a substantial fraction of sulfur compounds from the feed gas and flowing the resulting desulfurized gas into a CO2 removal unit to remove a substantial fraction of CO2 from the desulfurized gas.

公开(公告)号：US10421894B2

公开(公告)日：2019-09-24

申请号：US15634340

申请日：2017-06-27

Applicant: Research Triangle Institute

Inventor： Leah Marie Johnson ,  Ginger Denison Rothrock ,  Chasity Antoninette Norton ,  Nicolas Daniel Huffman ,  Jeffrey Brent Mecham

IPC: C09K8/588 ,  E21B33/138 ,  E21B43/20 ,  C09K8/508 ,  C09K8/512 ,  C09K8/516

Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.

公开(公告)号：US20190257737A1

公开(公告)日：2019-08-22

申请号：US16398400

申请日：2019-04-30

Applicant: Research Triangle Institute

Inventor： Anthony Clint Clayton ,  Howard Jerome Walls ,  David S. Ensor ,  Andrei Yurievich Khlystov

IPC: G01N15/14 ,  G01N21/53 ,  G01N15/06 ,  G01N15/02 ,  C12Q3/00 ,  G01N21/64

Abstract: Sample monitoring and flow control systems and methods are disclosed for monitoring of airborne particulates. A system may include a particle collection filter. The system also includes a fluid moving device for moving a sample through the particle collection filter. Further, the system includes a light source configured to direct irradiating light towards the particle collection filter. The system also includes a light detector positioned to receive the irradiating light passing through the particle collection filter and configured to generate a signal representative of an amount of the received light. Further, the system includes a controller configured to receive the signal and to control the fluid moving device based on the amount of the received light.