公开(公告)号：US20160263370A1

公开(公告)日：2016-09-15

申请号：US15163012

申请日：2016-05-24

Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.

Inventor： Ryan Sefkow ,  Christopher A. Crawford ,  Jeffrey Mitchell ,  Kevin Wilson ,  Raymond P. Bray ,  John R. Gonzalez

IPC: A61N1/05 ,  B29C45/14

CPC classification number: A61N1/0534 ,  B29C45/0055 ,  B29C45/14311 ,  B29C45/14467 ,  B29C45/14565 ,  B29C45/14614 ,  B29C45/14639 ,  B29C2045/14524 ,  B29C2793/009 ,  B29K2075/00 ,  B29K2995/0056 ,  B29L2031/7546

Abstract: In one embodiment, a method for fabricating a neurostimulation stimulation lead comprises: providing a plurality of ring components and hypotubes in a mold; placing an annular frame with multiple lumens over distal ends of the plurality of hypotubes to position a portion of each hypotube within a respective lumen of the annular frame; molding the plurality of ring components and the hypotubes to form a stimulation tip component for the stimulation lead, wherein the molding fills interstitial spaces between the plurality of ring components and hypotubes with insulative material; and forming segmented electrodes from the ring components after performing the molding.

公开(公告)号：US09370653B2

公开(公告)日：2016-06-21

申请号：US14541795

申请日：2014-11-14

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Ryan Sefkow ,  Christopher A. Crawford ,  Jeffrey Mitchell ,  Kevin Wilson ,  Raymond P. Bray ,  John R. Gonzalez

IPC: A61N1/05 ,  B29C45/14 ,  B29C45/00 ,  B29K75/00 ,  B29L31/00

CPC classification number: A61N1/0534 ,  B29C45/0055 ,  B29C45/14311 ,  B29C45/14467 ,  B29C45/14565 ,  B29C45/14614 ,  B29C45/14639 ,  B29C2045/14524 ,  B29C2793/009 ,  B29K2075/00 ,  B29K2995/0056 ,  B29L2031/7546

Abstract: In one embodiment, a method for fabricating a neurostimulation stimulation lead comprises: providing a plurality of ring components and hypotubes in a mold; placing an annular frame with multiple lumens over distal ends of the plurality of hypotubes to position a portion of each hypotube within a respective lumen of the annular frame; molding the plurality of ring components and the hypotubes to form a stimulation tip component for the stimulation lead, wherein the molding fills interstitial spaces between the plurality of ring components and hypotubes with insulative material; and forming segmented electrodes from the ring components after performing the molding.

Abstract translation: 在一个实施例中，制造神经刺激刺激引线的方法包括：在模具中提供多个环组件和海波管; 将多个腔的环形框架放置在多个海波管的远端上，以将每个海波管的一部分定位在环形框架的相应内腔内; 模制所述多个环组件和所述海波管以形成用于所述刺激引线的刺激尖端部件，其中所述模制件用绝缘材料填充所述多个环部件和所述海波管之间的间隙空间; 并且在进行模制之后，从环部件形成分段电极。

公开(公告)号：US20160089541A1

公开(公告)日：2016-03-31

申请号：US14869487

申请日：2015-09-29

Applicant: Advanced Neuromodulation Systems, Inc. dba St. Jude Neuromodulation Division

Inventor： Lalit Venkatesan

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36185 ,  A61N1/0529 ,  A61N1/36067 ,  A61N1/36178

Abstract: In one embodiment, a neurostimulation system for stimulating neuronal tissue of a brain of a patient, comprises: an implantable pulse generator comprising pulse generating circuitry and a controller; one or more stimulation leads comprising multiple electrodes, the implantable pulse generator adapted to connect to the one or more stimulation leads for delivery of generated electrical pulses to neuronal tissue of the patient; wherein the controller is adapted to control the implantable pulse generator to (i) generate a plurality of bursts of multiple pulses at a frequency of at least 100 Hz and (ii) to deliver each respective bursts on a randomly or pseudo-randomly selected electrode from multiple electrodes of the one or more stimulation leads, wherein a beginning of each burst in the plurality of bursts is separated from a beginning of its respective successive bursts by at least 50 milliseconds.

Abstract translation: 在一个实施例中，用于刺激患者的脑的神经元组织的神经刺激系统包括：包括脉冲发生电路和控制器的可植入脉冲发生器; 一个或多个刺激引线包括多个电极，所述可植入脉冲发生器适于连接到所述一个或多个刺激引线，用于将产生的电脉冲传送到患者的神经元组织; 其中所述控制器适于控制所述可植入脉冲发生器以（i）以至少100Hz的频率产生多个脉冲的突发，以及（ii）将随机或伪随机选择的电极上的每个相应的脉冲串从 所述一个或多个刺激引线的多个电极，其中所述多个脉冲串中的每个脉冲串的开始与其相应的连续脉冲串的开始相隔至少50毫秒。

公开(公告)号：US20160067496A1

公开(公告)日：2016-03-10

申请号：US14942800

申请日：2015-11-16

Applicant: Advanced Neuromodulation Systems, Inc., d/b/a St. Jude Medical Neuromodulation Division

Inventor： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

IPC: A61N1/36

CPC classification number: H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

Abstract: Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

Abstract translation: 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

公开(公告)号：US09238134B2

公开(公告)日：2016-01-19

申请号：US13717268

申请日：2012-12-17

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Peter R Lando

IPC: A61B19/00 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0539 ,  A61N1/36017 ,  A61N1/36067

Abstract: In one aspect, an apparatus is provided for securing an electrical stimulation lead in position in a person's brain. The apparatus includes a flexible disc comprising a substantially radial slot adapted to secure the lead in position within the brain after implantation. The slot is adapted to elastically expand as the lead is inserted into the slot and is also adapted to elastically contract on the lead to secure the lead in position within the brain after implantation. The apparatus further includes a ring adapted to seat within a burr hole formed in the person's skull. The ring comprises a channel adapted to receive and secure the flexible disc.

Abstract translation: 一方面，提供一种用于将电刺激引线固定在人的大脑中的位置的装置。 该装置包括柔性盘，其包括适于在植入之后将引线固定在大脑内部的位置的基本上径向的槽。 插槽适于在引线插入槽中时弹性膨胀，并且还适于在植入之后弹性收缩引线以将引线固定在大脑内的适当位置。 该装置还包括适于位于形成在人的头骨中的钻孔内的环。 环包括适于接收和固定软盘的通道。

公开(公告)号：US09186510B2

公开(公告)日：2015-11-17

申请号：US14101189

申请日：2013-12-09

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

IPC: A61N1/36 ,  A61N1/08 ,  A61N1/05 ,  A61N1/372

CPC classification number: H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

Abstract: Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

公开(公告)号：US20140155952A1

公开(公告)日：2014-06-05

申请号：US13913189

申请日：2013-06-07

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Andres M. Lozano ,  Helen S. Mayberg

IPC: A61N1/36 ,  A61B5/00

CPC classification number: A61M5/14276 ,  A61B5/4848 ,  A61N1/0534 ,  A61N1/36096 ,  A61N1/36185

Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Abstract translation: 本申请涉及使用电刺激和/或化学刺激来治疗抑郁症的方法和系统。 更具体地，该方法包括手术植入电刺激引线和/或导管，所述电刺激引线和/或导管与预定位置通信，所述预定部位耦合到信号发生器和/或输注泵，所述信号发生器和/或输注泵释放导致刺激的电信号和/或药物 的预定位置，从而治疗心情和/或焦虑。

公开(公告)号：US08738140B2

公开(公告)日：2014-05-27

申请号：US13914500

申请日：2013-06-10

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Dirk De Ridder

IPC: A61N1/36

CPC classification number: A61N1/3605 ,  A61M5/14276 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0553 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36036 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36085 ,  A61N1/36096 ,  A61N1/361 ,  A61N1/3611 ,  A61N1/36117 ,  A61N2/006

Abstract: A system and/or method treating for a neurological disorder by brain region stimulation. The system and/or method comprises a probe and a device to provide stimulation. The probe has a stimulation portion implanted in communication with a predetermined brain region site. The stimulation portion of the probe may be implanted in contact with a predetermined brain region.

Abstract translation: 通过脑区域刺激治疗神经障碍的系统和/或方法。 该系统和/或方法包括探针和用于提供刺激的装置。 探针具有植入与预定脑区部位连通的刺激部分。 探针的刺激部分可以植入与预定的脑区域接触。

公开(公告)号：US20130184793A1

公开(公告)日：2013-07-18

申请号：US13717268

申请日：2012-12-17

Applicant: Advanced Neuromodulation Systems, Inc.

Inventor： Peter R. Lando

IPC: A61N1/05

CPC classification number: A61N1/0539 ,  A61N1/36017 ,  A61N1/36067

Abstract: In one aspect, an apparatus is provided for securing an electrical stimulation lead in position in a person's brain. The apparatus includes a flexible disc comprising a substantially radial slot adapted to secure the lead in position within the brain after implantation. The slot is adapted to elastically expand as the lead is inserted into the slot and is also adapted to elastically contract on the lead to secure the lead in position within the brain after implantation. The apparatus further includes a ring adapted to seat within a burr hole formed in the person's skull. The ring comprises a channel adapted to receive and secure the flexible disc.

Abstract translation: 一方面，提供一种用于将电刺激引线固定在人的大脑中的位置的装置。 该装置包括柔性盘，其包括适于在植入之后将引线固定在大脑内部的位置的基本上径向的槽。 插槽适于在引线插入槽中时弹性膨胀，并且还适于在植入之后弹性收缩引线以将引线固定在大脑内的适当位置。 该装置还包括适于位于形成在人的头骨中的钻孔内的环。 环包括适于接收和固定软盘的通道。

公开(公告)号：US20130138191A1

公开(公告)日：2013-05-30

申请号：US13749189

申请日：2013-01-24

Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.

Inventor： Robert E. Jones

IPC: A61N1/05

CPC classification number: A61N1/0558 ,  A61B17/3468 ,  A61M25/02 ,  A61M2025/0293 ,  A61M2039/0223 ,  A61M2039/0261 ,  A61N1/05 ,  A61N1/057 ,  A61N2001/0582

Abstract: There is disclosed various embodiments of an implantable anchor for anchoring a medical lead within a patient. The implantable anchor includes a body having at least one lumen for receiving a medical lead, a cam integrated with the body and rotatable to extend into the lumen for engaging the medical lead and inhibiting the movement of the lead with respect to the anchor. The cam may include a handle for facilitating the rotation of the cam. A needle could be connected to the handle to facilitate the securing of the anchor to a portion of the patient.