公开(公告)号：US10436750B2

公开(公告)日：2019-10-08

申请号：US15698312

申请日：2017-09-07

Applicant: Shimadzu Corporation ,  Osaka University

Inventor： Kei Shinada ,  Katsuhisa Kitano

IPC: G01N27/68 ,  G01N27/66 ,  G01N30/64 ,  G01N33/00 ,  H05H1/00 ,  H05H1/24 ,  G01N30/02 ,  G01R19/00

Abstract: The dielectric barrier discharge ionization detector includes: a dielectric tube through which a plasma generation gas is passed; a high-voltage electrode formed on the outer wall of the dielectric tube; two ground electrodes and formed on the outer wall of the dielectric tube, with the high-voltage electrode in between; a voltage supplier for applying AC voltage between the high-voltage electrode and each ground electrode to generate electric discharge within the dielectric tube and thereby generate plasma from the plasma generation gas; and a charge-collecting section for detecting an ion current formed by ionized sample-component gas produced by the plasma. The distance between one ground electrode and the high-voltage electrode is longer than a discharge initiation distance between these two electrodes, while the distance between the other ground electrode and the high-voltage electrode is shorter than the discharge initiation distance between these two electrodes.

公开(公告)号：US10429745B2

公开(公告)日：2019-10-01

申请号：US15048584

申请日：2016-02-19

Applicant: Tokyo Electron Limited ,  Osaka University

Inventor： Michael Carcasi ,  Benjamen M. Rathsack ,  Mark H. Somervell ,  Wallace P. Printz ,  Seiji Nagahara ,  Seiichi Tagawa

IPC: G03F7/20 ,  G03F7/004 ,  G03F7/038 ,  G03F7/039 ,  G03F7/095

Abstract: Methods and systems for PS-CAR photoresist simulation are described. In an embodiment, a method includes determining by simulation at least one process parameter of a lithography process using a radiation-sensitive material. In such an embodiment, the radiation-sensitive material includes: a first light wavelength activation threshold that controls the generation of acid to a first acid concentration in the radiation-sensitive material and controls generation of photosensitizer molecules in the radiation-sensitive material, and a second light wavelength activation threshold that can excite the photosensitizer molecules in the radiation-sensitive material that results in the acid comprising a second acid concentration that is greater than the first acid concentration, the second light wavelength being different from the first light wavelength. In such an embodiment, the method also includes performing a lithography process using the previously-determined at least one process parameter.

公开(公告)号：US10428311B2

公开(公告)日：2019-10-01

申请号：US15325743

申请日：2015-07-15

Applicant: OSAKA UNIVERSITY

Inventor： Kiyotoshi Sekiguchi ,  Ko Tsutsui

IPC: C12N5/074 ,  C12N15/00 ,  C12N15/09

Abstract: The present invention provides a novel technique in a cell culture method using a cell culture vessel coated with a laminin fragment, which novel technique achieves cell culture as in the case of using a recommended coating concentration even when the coating concentration is lower than the recommended coating concentration. The present invention relates to a method for enhancing an activity for mammalian cultured cells of a laminin fragment or a variant thereof each having integrin binding activity.

公开(公告)号：US20190284246A1

公开(公告)日：2019-09-19

申请号：US16097219

申请日：2017-04-25

Applicant: OSAKA UNIVERSITY ,  BIKENBIOMICS CO., LTD

Inventor： Shota NAKAMURA ,  Kazuki KAWAHARA ,  Hiroya OKI ,  Takuya YOSHIDA ,  Tadayasu OHKUBO ,  Yuji KOBAYASHI ,  Takahiro MARUNO ,  Daisuke MOTOOKA ,  Shigeaki MATSUDA ,  Toshio KODAMA ,  Tetsuya IIDA ,  Yasumitsu TSUJINO ,  Shunsuke FUKAKUSA

IPC: C07K14/245

Abstract: A peptide capable of preventing pathogenic bacteria from colonizing in digestive organs comprises a first domain having an amino acid sequence capable of binding to a minor pilin of IVb fimbriae, and a second domain having an amino acid sequence capable of multimerization, the second domain connect to the first domain via a linker sequence.

公开(公告)号：US20190276309A1

公开(公告)日：2019-09-12

申请号：US16345199

申请日：2017-09-08

Applicant: OSAKA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Kiyotomi KANEDA ,  Takato MITSUDOME ,  Yasuteru KAJIKAWA ,  Yuuichirou HIRAI ,  Keisuke ONO

IPC: C01B3/32 ,  B01J23/52 ,  B01J27/18 ,  H01M8/0612 ,  C07F7/08

Abstract: Provided is a method for generating hydrogen at a desired rate, using a hydrogen storage material that can be stored and transported safely and inexpensively. The method according to the present invention for producing a silanol compound and hydrogen includes subjecting a hydrosilane compound and water to a reaction with each other in the presence of a solid catalyst to give a silanol compound and hydrogen. The solid catalyst includes hydroxyapatite and gold particles supported on the hydroxyapatite, where the gold particles have an average particle size of 2.5 nm or less. The reaction in the method according to the present invention for producing a silanol compound and hydrogen is preferably performed in an air atmosphere. The reaction in the method according to the present invention for producing a silanol compound and hydrogen can be performed with application of substantially no heat and no activated energy rays.

公开(公告)号：US20190271708A1

公开(公告)日：2019-09-05

申请号：US16302235

申请日：2017-05-17

Applicant: Osaka University ,  Shiseido Company, Ltd.

Inventor： Yoshitaka Isaka ,  Tomonori Kimura ,  Keiko Yasuda ,  Kenji Hamase ,  Masashi Mita

IPC: G01N33/68

Abstract: The purpose of the present invention is to provide: a blood sample analysis method for determining diabetes complications in subjects with kidney damage on the basis of D- and L-amino acid content, from a blood sample; a method for examining diabetes complications; and a sample analysis system that outputs pathological information about diabetes complications. The purpose of this invention is achieved by using at least one amino acid selected from the group consisting of D-aspartic acid, D-proline, L-glutamine, and L-isoleucine, in order to determine diabetes complications.

公开(公告)号：US20190270996A1

公开(公告)日：2019-09-05

申请号：US16410803

申请日：2019-05-13

Applicant: National University Corporation Tokyo Medical and Dental University ,  Osaka University

Inventor： TAKANORI YOKOTA ,  Kazutaka Nishina ,  Satoshi Obika ,  Hidehiro Mizusawa

IPC: C12N15/113 ,  C12N15/11

Abstract: A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5′ terminal side of the region, (c) one or more nucleotide analogs located on 3′ terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides.

公开(公告)号：US20190257787A1

公开(公告)日：2019-08-22

申请号：US16065633

申请日：2016-12-19

Applicant: Osaka University

Inventor： Takashi WASHIO ,  Tomoji KAWAI ,  Masateru TANIGUCHI ,  Makusu TSUTSUI ,  Kazumichi YOKOTA ,  Akira ISHI ,  Takeshi YOSHIDA

IPC: G01N27/447 ,  G01N33/487

Abstract: The present invention provides a number analyzing method, a number analyzing device, and a storage medium for number analysis, which enable, with high accuracy, analysis of the number or number distribution of particulate or molecular analytes according to the kinds of the analytes. A computer control program is executed on the basis of a data group of particle-passage detection signals which are detected by a nanopore device (8) in accordance with passage of subject particles through a through-hole (12). Also, a particle type distribution estimating program, which is a number deriving means, is executed, to estimate probability density on the basis of a data group based on feature values indicating feature of the waveforms of pulse signals which correspond to the passage of particles and which are obtained as the particle-passage detection signals. Thus, the number of particles can be derived for each particle type.

公开(公告)号：US10364276B2

公开(公告)日：2019-07-30

申请号：US14114395

申请日：2012-04-03

Applicant: Katsuto Tamai ,  Takehiko Yamazaki ,  Tsutomu Kanezaki ,  Shigeru Sakurai ,  Yukiko Noguchi ,  Mayumi Endo ,  Natsumi Hamabuchi ,  Kana Naito

Inventor： Katsuto Tamai ,  Takehiko Yamazaki ,  Tsutomu Kanezaki ,  Shigeru Sakurai ,  Yukiko Noguchi ,  Mayumi Endo ,  Natsumi Hamabuchi ,  Kana Naito

IPC: A61K39/00 ,  A61K38/00 ,  C07K14/00 ,  C07K14/47 ,  A61K38/17

Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.

公开(公告)号：US20190206406A1

公开(公告)日：2019-07-04

申请号：US16301641

申请日：2017-05-19

Applicant: NIPPON TELEGRAPH AND TELEPHONE CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hiroaki SUGIYAMA ,  Toyomi MEGURO ,  Junji YAMATO ,  Yuichiro YOSHIKAWA ,  Hiroshi ISHIGURO

IPC: G10L15/22 ,  G10L13/04 ,  G10L15/26 ,  B25J11/00

CPC classification number: G10L15/22 ,  A63H11/00 ,  B25J11/0005 ,  B25J13/08 ,  G10L13/00 ,  G10L13/043 ,  G10L15/00 ,  G10L15/10 ,  G10L15/265

Abstract: The present invention improves a sense of participation in a topic and enables a dialogue to continue for a long time. A dialogue system 12 includes at least an input part 1 that receives a user's utterance and a presentation part 5 that presents an utterance. In an utterance receiving step, the input part 1 receives an utterance performed by the user. In a first presentation step, the presentation part 5 presents an utterance determined based on scenarios stored in advance. In a second presentation step, the presentation part 5 presents the utterance determined based on the user's utterance contents. A dialogue control part 8 performs control to execute a dialogue at least including a first dialogue flow which is a dialogue including the utterance receiving step and the first presentation step at least one time respectively based on a predetermined scenario, and a second dialogue flow which is a dialogue including the utterance receiving step and the second presentation step at least one time respectively.