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221.发明申请公开(公告)号：US20200047182A1
公开(公告)日：2020-02-13
申请号：US15774558
申请日：2016-11-14
Inventor： Deirdre Meldrum , Laimonas Kelbauskas , Wacey Teller , Meryl Rodrigues , Hong Wang , Ganquan Song , Yanqing Tian , Fengyu Su , Xiangxing Kong , Liqiang Zhang
IPC: B01L3/00
Abstract: A microfluidic device includes a first substrate including at least one microfluidic channel and a plurality of microwells, as well as a cooperating second substrate defining multiple split-walled cell trap structures that are registered with and disposed within the plurality of microwells. A method for performing an assay includes flowing cells and a first aqueous medium into a plurality of microwells of a microfluidic device, wherein each microwell includes a cell trap structure configured to trap at least one cell. The method further comprises flowing a nonpolar fluid with low permeability for analytes of interest through a microfluidic channel to flush a portion of the first aqueous medium from the microfluidic channel while retaining another portion of the first aqueous medium and at least one cell within each microwell. Surface tension at a non-polar/polar medium interface prevents molecule exchange between interior and exterior portions of microwells.
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公开(公告)号：US10558269B2
公开(公告)日：2020-02-11
申请号：US16336065
申请日：2017-09-22
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , Francesco Chinello , Daisuke Shibata , Domenico Prattichizzo
Inventor： Marco Santello , Francesco Chinello , Daisuke Shibata , Domenico Prattichizzo
Abstract: A device for providing cutaneous sensations to a fingertip includes a lower base, an upper platform positioned over and mechanically connected to the lower base, and a shear plate positioned between the lower base and the upper platform and mechanically connected to the lower base. When a fingertip is positioned between the upper platform and the lower base, the upper platform is selectively vertically translatable relative to the lower base to provide a compressive force, and the shear plate is selectively laterally translatable relative to the lower base to provide a shear force. Accordingly, a wearable fingertip device having two degrees-of-freedom (DoF) to provide consecutive and/or concurrent compressive force and/or shear force to a fingertip is provided. The wearable fingertip device can be used in various scenarios; is portable, easily wearable, and easily manufacturable; and has low overall operating power requirements.
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公开(公告)号：US20200011778A1
公开(公告)日：2020-01-09
申请号：US16482661
申请日：2018-02-07
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ADVANCED TEAR DIAGNOSTICS
Inventor： Mackenzie Honikel , Chi Lin , Andrew Penman , Brittney Cardinell , Jeffrey LaBelle , Pierce Youngbar , Marcus Smith
IPC: G01N13/04 , G01N33/487 , G01N33/493 , G01N33/49
Abstract: Osmolality and osmolality sensors and methods utilizing electrochemical impedance to detect changes in impedance to varying salinity concentrations. By way of example, the impedance reported at the specified frequency varies logarithmically with the concentration of sodium chloride subject to the sensor surface. Measurements obtained by the sensors and methods herein are utilized, for example, to differentiate between the clinical stages of dry eye disease (290-316 mOsm/L) to complement the current diagnostic procedures. Blood serum, urinalysis, and saliva also may be tested and the corresponding osmolarity or osmolality level evaluated for indications of a disease or condition.
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公开(公告)号：US10482367B2
公开(公告)日：2019-11-19
申请号：US16299884
申请日：2019-03-12
Inventor： Paul B. Johnson , Jose Antonio Bautista-Martinez , Cody A. Friesen , Elise Switzer
Abstract: The disclosed technology relates generally to apparatus comprising conductive polymers and more particularly to tag and tag devices comprising a redox-active polymer film, and method of using and manufacturing the same. In one aspect, an apparatus includes a substrate and a conductive structure formed on the substrate which includes a layer of redox-active polymer film having mobile ions and electrons. The conductive structure further includes a first terminal and a second terminal configured to receive an electrical signal therebetween, where the layer of redox-active polymer is configured to conduct an electrical current generated by the mobile ions and the electrons in response to the electrical signal. The apparatus additionally includes a detection circuit operatively coupled to the conductive structure and configured to detect the electrical current flowing through the conductive structure.
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公开(公告)号：US20190336596A1
公开(公告)日：2019-11-07
申请号：US16404698
申请日：2019-05-06
Inventor： Hugh Mason , Andrew Diamos , Mary Pardhe
IPC: A61K39/29 , A61K39/12 , A61P31/20 , C12N7/00 , A61K39/145
Abstract: The disclosure relates to vaccination compositions, for example, against human papillomavirus, Zika virus, and flu virus. The disclosure also relates to vectors for producing the virus-like particles and immune complex platforms of the vaccination compositions.
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Patent Agency Ranking
公开(公告)号：US10468203B2
公开(公告)日：2019-11-05
申请号：US15755027
申请日：2016-08-25
Inventor： Hanqing Jiang , Prithwish Chatterjee , Wenwen Xu , Xu Wang
IPC: H01G11/68 , H01G11/30 , H01G11/52 , H01G11/80 , A23L33/16 , A61N1/32 , H01G11/58 , H01G11/86 , H02J7/02 , H02J7/34
Abstract: Systems and methods are described for an edible capacitive power source such as a supercapacitor device. The capacitive power source includes an anode electrode, an anode current collector, a cathode electrode, and a cathode current collector, arranged in layers with a separator layer positioned between the anode electrode and the cathode electrode forming a symmetrical electrical double-layer capacitor. The anode electrode, the anode current collector, the cathode electrode, the cathode current collector, and the separator layer are all constructed of non-toxic, edible materials. The packaging material, the conductive anode tab, and the conductive cathode tab are all also constructed of non-toxic, edible materials forming a completely edible capacitive power source package.
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公开(公告)号：US20190317040A1
公开(公告)日：2019-10-17
申请号：US16389859
申请日：2019-04-19
Inventor： Stuart LINDSAY , Peiming ZHANG
IPC: G01N27/327 , C12Q1/6869 , G01N27/02 , G01N33/487
Abstract: An system for recognition of a translocating polymeric target molecule includes a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. A pair of spaced apart sensing electrodes border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. Each affinity element may be connected to its corresponding electrode via one or more intermediary compounds, such as a linker molecule and/or an electrode attachment molecule. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. During translocation, the electrodes, affinity elements and first and second portions of the target molecule complete an electrical circuit and allow a measurable electrical current to pass between the first and second electrodes. The time-varying nature of this electrical current, and the specific affinity elements employed, allow one to characterize the target molecule.
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公开(公告)号：US10447481B2
公开(公告)日：2019-10-15
申请号：US15459597
申请日：2017-03-15
Inventor： Huahong Tu , Adam Doupe , Gail-Joon Ahn , Ziming Zhao
Abstract: Various embodiments of a system and method for authenticating a call request header including identity information that is lightweight and deployable in VoIP and PSTN systems are disclosed.
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公开(公告)号：US10441803B2
公开(公告)日：2019-10-15
申请号：US15226775
申请日：2016-08-02
Inventor： Bruce C. Towe , Daniel Gulick
Abstract: A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.
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公开(公告)号：US20190302122A1
公开(公告)日：2019-10-03
申请号：US16317184
申请日：2017-07-11
Applicant: Benjamin KATCHMAN , Karen ANDERSON , Garrick WALLSTROM , Joshua LABAER , Daniel CRAMER , ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Benjamin Katchman , Karen Anderson , Garrick Wallstrom , Joshua LaBaer , Daniel Cramer
IPC: G01N33/574
Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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