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1.发明申请公开(公告)号：US20200064297A1
公开(公告)日：2020-02-27
申请号：US16495682
申请日：2018-03-20
发明人： David Probst , Chi Lin , Marcus Smith , Jeffrey LaBelle
IPC分类号： G01N27/327 , G01N33/543 , G01N27/02
摘要： Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.
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2.发明授权公开(公告)号：US11549904B2
公开(公告)日：2023-01-10
申请号：US16495682
申请日：2018-03-20
发明人： David Probst , Chi Lin , Marcus Smith , Jeffrey LaBelle
IPC分类号： G01N33/543 , G01N27/327 , G01N27/02 , G01N33/92
摘要： Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.
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公开(公告)号：US20200011778A1
公开(公告)日：2020-01-09
申请号：US16482661
申请日：2018-02-07
发明人： Mackenzie Honikel , Chi Lin , Andrew Penman , Brittney Cardinell , Jeffrey LaBelle , Pierce Youngbar , Marcus Smith
IPC分类号： G01N13/04 , G01N33/487 , G01N33/493 , G01N33/49
摘要： Osmolality and osmolality sensors and methods utilizing electrochemical impedance to detect changes in impedance to varying salinity concentrations. By way of example, the impedance reported at the specified frequency varies logarithmically with the concentration of sodium chloride subject to the sensor surface. Measurements obtained by the sensors and methods herein are utilized, for example, to differentiate between the clinical stages of dry eye disease (290-316 mOsm/L) to complement the current diagnostic procedures. Blood serum, urinalysis, and saliva also may be tested and the corresponding osmolarity or osmolality level evaluated for indications of a disease or condition.
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公开(公告)号：US20210223196A1
公开(公告)日：2021-07-22
申请号：US16612270
申请日：2018-05-04
申请人： Arizona Board of Regents on behalf of Arizona State University , MAYO FOUNDAION FOR MEDICAL EDUCATION AND RESEARCH
发明人： Jeffrey LaBelle , Garrett Repp , Chi Lin , Mark Spano , Jennifer Blain Christen , Hongwu Jiang , Marcus Smith , Andrew Penman , Pierce Youngbar , Mackenzie Honikel , Curtiss Cook
IPC分类号： G01N27/02 , G01N27/327 , G01N33/487 , G01N27/22 , G01N35/00 , G01N33/569 , G01N33/66 , G01N33/53
摘要： The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.
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公开(公告)号：US11714083B2
公开(公告)日：2023-08-01
申请号：US16612270
申请日：2018-05-04
申请人： Arizona Board of Regents on behalf of Arizona State University , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , AXIM Biotechnologies, Inc.
发明人： Jeffrey LaBelle , Garrett Repp , Chi Lin , Mark Spano , Jennifer Blain Christen , Hongwu Jiang , Marcus Smith , Andrew Penman , Pierce Youngbar , Mackenzie Honikel , Curtiss Cook
IPC分类号： G01N33/543 , G01N27/02 , G01N27/327 , G01N33/487 , G01N33/53 , G01N33/569 , G01N33/66 , G01N35/00
CPC分类号： G01N33/5438 , G01N27/026 , G01N27/3276 , G01N33/48707 , G01N33/5308 , G01N33/56983 , G01N33/66 , G01N35/00029 , G01N2333/075
摘要： The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.
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6.发明公开公开(公告)号：US20230184755A1
公开(公告)日：2023-06-15
申请号：US18084320
申请日：2022-12-19
发明人： David Probst , Chi Lin , Marcus Smith , Jeffrey LaBelle
IPC分类号： G01N33/543 , G01N27/02 , G01N27/327 , G01N33/92
CPC分类号： G01N33/5438 , G01N27/026 , G01N27/3275 , G01N33/543 , G01N33/54353 , G01N33/92 , G01N27/02
摘要： Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.
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