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1.发明授权公开(公告)号：US11549904B2
公开(公告)日：2023-01-10
申请号：US16495682
申请日：2018-03-20
发明人： David Probst , Chi Lin , Marcus Smith , Jeffrey LaBelle
IPC分类号： G01N33/543 , G01N27/327 , G01N27/02 , G01N33/92
摘要： Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.
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公开(公告)号：US20200011778A1
公开(公告)日：2020-01-09
申请号：US16482661
申请日：2018-02-07
发明人： Mackenzie Honikel , Chi Lin , Andrew Penman , Brittney Cardinell , Jeffrey LaBelle , Pierce Youngbar , Marcus Smith
IPC分类号： G01N13/04 , G01N33/487 , G01N33/493 , G01N33/49
摘要： Osmolality and osmolality sensors and methods utilizing electrochemical impedance to detect changes in impedance to varying salinity concentrations. By way of example, the impedance reported at the specified frequency varies logarithmically with the concentration of sodium chloride subject to the sensor surface. Measurements obtained by the sensors and methods herein are utilized, for example, to differentiate between the clinical stages of dry eye disease (290-316 mOsm/L) to complement the current diagnostic procedures. Blood serum, urinalysis, and saliva also may be tested and the corresponding osmolarity or osmolality level evaluated for indications of a disease or condition.
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3.发明申请公开(公告)号：US20200064297A1
公开(公告)日：2020-02-27
申请号：US16495682
申请日：2018-03-20
发明人： David Probst , Chi Lin , Marcus Smith , Jeffrey LaBelle
IPC分类号： G01N27/327 , G01N33/543 , G01N27/02
摘要： Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.
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公开(公告)号：US20180095029A1
公开(公告)日：2018-04-05
申请号：US15546790
申请日：2016-02-03
发明人： Jeffrey LaBelle
CPC分类号： G01N21/35 , C09K11/06 , G02B23/12 , H01J29/385 , H01J31/50
摘要： Methods and apparatus relating to light amplification technology that has the ability to transform and amplify light to be seen in the visible spectrum by the user (FIG. 2). The biologically-based light amplification system including a reaction center, a proton gradient area, and a light amplification area, and may be configured such that light entering the system through the reaction center produces a proton gradient, which in turn acts upon reactants in the proton gradient area, and then causes a product to enter the light amplification area and thereby drive a bioluminescent or phosphorescent reaction to amplify the light The methods and apparatus use solely biological processes without any external power supply.
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公开(公告)号：US20170234894A1
公开(公告)日：2017-08-17
申请号：US15503364
申请日：2015-07-27
发明人： Jeffrey LaBelle , Tina Hakimi , Brittney Cardinell
IPC分类号： G01N33/74 , G01N27/02 , G01N27/327 , G01N33/543 , G01N27/30
CPC分类号： G01N27/327 , A61B5/053 , A61B5/14507 , A61B5/14546 , A61B5/165 , A61B2562/0215 , G01N27/026 , G01N27/301 , G01N27/3273 , G01N33/5436 , G01N33/5438 , G01N33/743 , G01N2800/7004
摘要： Electrochemical impedance-based label-free and rapid biosensor for select bodily fluid biomolecule levels. Monoclonal antibodies to of biomolecule such as Cortisol were covalently attached to a 16-mercaptohexadecanoic acid functionalized gold working electrode using zero-length crosslinkers N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and 10 mM N-hydroxysulfosuccinimide. Cortisol was detected in phosphate buffered saline (simulated tear fluid) using a simple ferrocyanide reagent with a lower limit of detection of 18.73 pM and less than 10% relative standard deviation.
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公开(公告)号：US11714083B2
公开(公告)日：2023-08-01
申请号：US16612270
申请日：2018-05-04
申请人： Arizona Board of Regents on behalf of Arizona State University , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , AXIM Biotechnologies, Inc.
发明人： Jeffrey LaBelle , Garrett Repp , Chi Lin , Mark Spano , Jennifer Blain Christen , Hongwu Jiang , Marcus Smith , Andrew Penman , Pierce Youngbar , Mackenzie Honikel , Curtiss Cook
IPC分类号： G01N33/543 , G01N27/02 , G01N27/327 , G01N33/487 , G01N33/53 , G01N33/569 , G01N33/66 , G01N35/00
CPC分类号： G01N33/5438 , G01N27/026 , G01N27/3276 , G01N33/48707 , G01N33/5308 , G01N33/56983 , G01N33/66 , G01N35/00029 , G01N2333/075
摘要： The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.
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公开(公告)号：US11291563B2
公开(公告)日：2022-04-05
申请号：US16806418
申请日：2020-03-02
发明人： Jeffrey LaBelle , Courtney Mason
摘要： A prosthetic device includes an internal frame assembled from multiple longitudinal members and multiple transverse members that are substantially planar in character and are arranged to be joined together. A medially arranged opening is defined in each transverse member, and is substantially registered with openings of adjacent transverse members to form a longitudinal passage, such as may be useful to receive an actuator and/or other items. At least some transverse members differ from one another in one or more of shape, length, or width. A covering member may be provided over the internal frame. Rear-facing gaps in transverse members may receive one or more elements such as dampers, batteries, or the like.
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公开(公告)号：US10939857B2
公开(公告)日：2021-03-09
申请号：US16011796
申请日：2018-06-19
发明人： Jeffrey LaBelle , Anngela Adams , Garrett Repp
IPC分类号： A61B5/1486 , C12Q1/00 , G01N27/327 , G01N33/66 , A61B5/145 , A61B5/15 , A61B5/00 , A61B5/157 , A61B5/1495 , G01N33/49
摘要： A blood glucose sensing device includes a substrate, multiple three-dimensionally (3D) printed electrode leads comprising graphene arranged on or over the substrate, and glucose monitoring chemistry arranged in or on (e.g., adsorbed in) at least one of the 3D printed electrode leads. An end portion of a counter electrode lead may partially surround an end portion of a working electrode lead, and a reference lead may be further provided, Optionally, the 3D printed electrode leads may include a thermoplastic material, such as an aliphatic polyester. The glucose monitoring chemistry may include an enzyme.
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公开(公告)号：US20190054277A1
公开(公告)日：2019-02-21
申请号：US16078388
申请日：2017-02-21
发明人： Jeffrey LaBelle , Julio Morera , Marco Santello
IPC分类号： A61M25/09
摘要： Guidewires useful for cooperating with catheters may be actively steered and/or provide adjustable stiffness. Angle or curvature of a guidewire, and/or flexural modulus of a guidewire, may be adjusted at one or more locations between ends thereof. Variable stiffness segments may include electrically operated compressible and/or extensible materials. Multiple tensile elements may terminate at different body elements to adjust angle or curvature at multiple locations. Multiple circumferentially and/or radially contractible fiber regions may be provided and distributed over a length of a guidewire. Adjustable flexure elements arranged in or along a guidewire may be electrically operated. A flexible core member may be centrally arranged in a tubular body. A flexible guide wire or track may cooperate with electrically operable motor units.
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10.发明公开公开(公告)号：US20230184755A1
公开(公告)日：2023-06-15
申请号：US18084320
申请日：2022-12-19
发明人： David Probst , Chi Lin , Marcus Smith , Jeffrey LaBelle
IPC分类号： G01N33/543 , G01N27/02 , G01N27/327 , G01N33/92
CPC分类号： G01N33/5438 , G01N27/026 , G01N27/3275 , G01N33/543 , G01N33/54353 , G01N33/92 , G01N27/02
摘要： Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.
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