公开(公告)号：US20090170790A1

公开(公告)日：2009-07-02

申请号：US11577900

申请日：2005-10-25

Applicant: Biswajit Das ,  Mohammad Salman ,  Santosh Haribhau Kurhade ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Rita Katoch ,  Anish Bandyopadhyay ,  Ashok Rattan

Inventor： Biswajit Das ,  Mohammad Salman ,  Santosh Haribhau Kurhade ,  Ramadass Venkataramanan ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Rita Katoch ,  Anish Bandyopadhyay ,  Ashok Rattan

IPC: A61K31/7028 ,  C07H17/08 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as anti-bacterial agents. Compounds disclosed herein can be used for the treating or preventing conditions caused by or contributed to by gram positive, gram negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp., Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus, Enterobactericeae or any combination thereof. Also provided are processes for preparing compounds disclosed herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，更具体地针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫萨卡氏菌，衣原体属， 支原体属，军团菌属，分枝杆菌属，幽杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属，肠杆菌属或其任何组合。 还提供了用于制备本文公开的化合物的方法，其合成中使用的中间体，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US07456254B2

公开(公告)日：2008-11-25

申请号：US11104877

申请日：2005-04-13

Applicant: Steven G. Wright ,  Troy Christenson ,  Thean Y. Yeah ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christenson ,  Thean Y. Yeah ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

IPC: C07K14/00 ,  A61K9/14

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

公开(公告)号：US20080287376A1

公开(公告)日：2008-11-20

申请号：US11572619

申请日：2005-07-28

Applicant: Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

Inventor： Biswajit Das ,  Mohammad Salman ,  Atul Kashinath Hajare ,  Ramadass Venkataramanan ,  Rita Katoch ,  Rajesh Kumar ,  Gobind Singh Kapkoti ,  Anjan Chakrabarti ,  Anish Bandyopadhyay ,  Santosh Haribhau Kurhade ,  Yogesh Baban Surase ,  Ashok Rattan

IPC: A61K31/7048 ,  C07H17/08 ,  A61P31/04

CPC classification number: C07H17/00

Abstract: The present invention provides ketolide derivatives, which can be used as antibacterial agents. In particular, compounds described herein can be used for treating or preventing conditions caused by or contributed to by Gram-positive, Gram-negative or anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Moraxalla spp. Chlamydia spp., Mycoplasm, Legionella spp., Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebaclerium, Bacillus or Enterobactericeae. Also provided are processes for preparing such ketolide derivatives, pharmaceutical compositions thereof, and methods of treating bacterial infections.

Abstract translation: 本发明提供可用作抗菌剂的酮内酯衍生物。 特别地，本文所述的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性或厌氧细菌引起或促成的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，莫拉萨氏菌。 衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，棒状杆菌属，芽孢杆菌属或肠杆菌属。 还提供了制备这种酮内酯衍生物的方法，其药物组合物和治疗细菌感染的方法。

公开(公告)号：US20080125348A1

公开(公告)日：2008-05-29

申请号：US11826534

申请日：2007-07-16

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Y. Yeah ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Y. Yeah ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino

IPC: A61K38/00

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

公开(公告)号：US07355207B2

公开(公告)日：2008-04-08

申请号：US11135661

申请日：2005-05-24

Applicant: Rajesh Kumar ,  Tsuyoshi Yamamoto ,  Hiroki Nakamura ,  Toshiyuki Morishita ,  Takasumi Ohyanagi ,  Atsuo Watanabe

Inventor： Rajesh Kumar ,  Tsuyoshi Yamamoto ,  Hiroki Nakamura ,  Toshiyuki Morishita ,  Takasumi Ohyanagi ,  Atsuo Watanabe

IPC: H01L29/15 ,  H01L31/0312

CPC classification number: H01L29/1608 ,  H01L27/098 ,  H01L29/0619 ,  H01L29/66068 ,  H01L29/8083

Abstract: A manufacturing method of a silicon carbide semiconductor device includes the steps of: preparing a semiconductor substrate including a silicon carbide substrate, a drift layer and a first semiconductor layer; forming a plurality of first trenches in a cell portion; forming a gate layer on an inner wall of each first trench by an epitaxial growth method; forming a first insulation film on the surface of the semiconductor substrate; forming a gate electrode on the first insulation film for connecting to the gate layer electrically; forming a source electrode on the first insulation film for connecting to the first semiconductor layer in the cell portion; and forming a drain electrode connected to the silicon carbide substrate electrically.

Abstract translation: 碳化硅半导体器件的制造方法包括以下步骤：制备包括碳化硅衬底，漂移层和第一半导体层的半导体衬底; 在单元部分中形成多个第一沟槽; 通过外延生长法在每个第一沟槽的内壁上形成栅极层; 在所述半导体衬底的表面上形成第一绝缘膜; 在所述第一绝缘膜上形成用于电连接到所述栅极层的栅电极; 在所述第一绝缘膜上形成用于连接到所述单元部分中的所述第一半导体层的源电极; 以及电连接到所述碳化硅衬底的漏电极。

公开(公告)号：US20080031145A1

公开(公告)日：2008-02-07

申请号：US11462587

申请日：2006-08-04

Applicant: Randall P.J. Ethier ,  Rajesh Kumar

Inventor： Randall P.J. Ethier ,  Rajesh Kumar

IPC: H04J3/14 ,  H04L12/56

CPC classification number: H04L29/06027 ,  H04L41/12 ,  H04L43/00 ,  H04L43/0829 ,  H04L43/0852 ,  H04L43/087 ,  H04L45/26 ,  H04L45/28 ,  H04L65/80

Abstract: A method for initiating a remote trace route includes establishing a communication session between a first endpoint and a second endpoint. The method also includes detecting at the first endpoint a quality impairment in a communication sent from the second endpoint. In response to detecting the quality impairment, the method includes sending a request from the first endpoint to the second endpoint for the second endpoint to initiate a trace route from the second endpoint to the first endpoint. Upon receiving the request at the second endpoint, the method includes initiating a trace route from the second endpoint to the first endpoint.

Abstract translation: 用于发起远程跟踪路由的方法包括在第一端点和第二端点之间建立通信会话。 该方法还包括在第一端点处检测从第二端点发送的通信中的质量损害。 响应于检测到质量损害，该方法包括向第二端点发送从第一端点到第二端点的请求以发起从第二端点到第一端点的跟踪路由。 在第二端点接收到请求时，该方法包括发起从第二端点到第一端点的跟踪路由。

公开(公告)号：US20070287660A1

公开(公告)日：2007-12-13

申请号：US11605480

申请日：2006-11-29

Applicant: Girish Sahai ,  Rajesh Kumar ,  Chaiti Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

Inventor： Girish Sahai ,  Rajesh Kumar ,  Chaiti Roy ,  Kammara Rajagopal ,  Deepak Nihalani ,  Vasudha Sundaram ,  Mahavir Yadav

IPC: A61K38/00 ,  A61P9/00 ,  C07K14/00

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/3153 ,  C07K19/00 ,  C07K2319/70

Abstract: Clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.

Abstract translation: 具有改变的纤溶酶原特征的凝块特异性链激酶蛋白质，包括增强的纤维蛋白选择性。 这些蛋白质的纤溶酶原激活的动力学与天然链激酶的动力学不同，因为纤溶酶原对纤溶酶的催化转化的初始速率暂时延迟或滞后。 还公开了制备蛋白质的方法。

公开(公告)号：US20070286351A1

公开(公告)日：2007-12-13

申请号：US11419913

申请日：2006-05-23

Applicant: Randall P.J. Ethier ,  Rajesh Kumar ,  Robert J. Biskner ,  Chelliah Sivachelvan ,  Mohamed S. Mostafa ,  Scott S. Firestone ,  Michael A. Ramalho ,  Kevin J. Connor ,  James C. Frauenthal ,  Michael P. Hammer

Inventor： Randall P.J. Ethier ,  Rajesh Kumar ,  Robert J. Biskner ,  Chelliah Sivachelvan ,  Mohamed S. Mostafa ,  Scott S. Firestone ,  Michael A. Ramalho ,  Kevin J. Connor ,  James C. Frauenthal ,  Michael P. Hammer

IPC: H04M3/08 ,  H04M3/22 ,  H04M1/24

CPC classification number: H04M3/2236 ,  H04L65/80 ,  H04M2201/18

Abstract: A method for adaptive media quality monitoring includes monitoring at least one metric of a call between at least two endpoints and detecting a threshold crossing event via the monitoring of the at least one metric. The method also includes executing a threshold crossing action based on detecting the threshold crossing event. The threshold crossing action comprises monitoring at least one additional metric of the call.

Abstract translation: 用于自适应媒体质量监测的方法包括：监视至少两个端点之间的呼叫的至少一个度量，并且通过监视所述至少一个度量来检测阈值交叉事件。 该方法还包括基于检测阈值交叉事件来执行阈值交叉动作。 阈值交叉动作包括监视呼叫的至少一个附加度量。

公开(公告)号：US20070135539A1

公开(公告)日：2007-06-14

申请号：US11588855

申请日：2006-10-27

Applicant: Ashok Cholli ,  Rajesh Kumar

Inventor： Ashok Cholli ,  Rajesh Kumar

IPC: C08K5/524 ,  C07F9/6574

CPC classification number: C07F9/1414 ,  C07F9/1412 ,  C07F9/145 ,  C07F9/6571 ,  C07F9/65746 ,  C08K5/524 ,  C08K5/527

Abstract: Sterically hindered phenol and phosphite based compounds, represented by a formula selected from I-III: and their use as antioxidants in a wide range of materials including, but not limited to, food, plastics, elastomers, composites and petroleum based products is disclosed herein.

Abstract translation: 由选自I-III的式表示的受阻酚和亚磷酸酯基化合物及其作为抗氧化剂在广泛范围的材料中的用途，包括但不限于食品，塑料，弹性体，复合材料和石油基产品。 。

公开(公告)号：US07223440B2

公开(公告)日：2007-05-29

申请号：US11312371

申请日：2005-12-21

Applicant: Michael E. Rickey ,  J. Michael Ramstack ,  Rajesh Kumar

Inventor： Michael E. Rickey ,  J. Michael Ramstack ,  Rajesh Kumar

IPC: B01J13/12

CPC classification number: A61K38/09 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1682 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/519 ,  B01J8/025 ,  B01J13/08 ,  B01J13/12 ,  B01J13/206 ,  B01J14/00 ,  B01J19/121 ,  B01J19/122 ,  B01J19/2415 ,  B01J2219/0877

Abstract: Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.

Abstract translation: 制备具有降低的残留溶剂水平的微粒的方法。 微粒与非水洗涤体系接触以降低微粒中残留溶剂的含量。 优选的非水洗涤系统包括100％乙醇和乙醇与庚烷的混合物。 可以使用硬化溶剂和洗涤溶剂的溶剂共混物在一个步骤中硬化和洗涤微粒，从而不需要后硬化洗涤步骤。