公开(公告)号：US07034200B2

公开(公告)日：2006-04-25

申请号：US09818943

申请日：2001-03-28

Applicant: Ulf Eriksson ,  Xuri Li ,  Annica Ponten ,  Karin Aase ,  Hong Li

Inventor： Ulf Eriksson ,  Xuri Li ,  Annica Ponten ,  Karin Aase ,  Hong Li

IPC: G01N33/00

CPC classification number: C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0375 ,  C07K14/49 ,  C07K2319/02 ,  C12N2830/008

Abstract: Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C (PDGF-C) or an analog thereof, or a functional fragment of PDGF-C or analog thereof. These animals are useful for studying disease states characterized by overexpression of PDGF-C, as well as useful for evaluating therapies intended to treat such diseases.

公开(公告)号：US20060075004A1

公开(公告)日：2006-04-06

申请号：US10958724

申请日：2004-10-04

Applicant: Christopher Stakutis ,  Erik Wilkinson ,  Hong Li

Inventor： Christopher Stakutis ,  Erik Wilkinson ,  Hong Li

IPC: G06F17/30

CPC classification number: G06F17/30067 ,  Y10S707/99953 ,  Y10S707/99954

Abstract: Provided are a method, system, and program for replicating a file. A file is copied to a target storage file system stored as a base file. A reference file comprising the copied file is generated at a local storage. An update is applied to the file at the local storage. A delta file is generated indicating differences between the updated file at the local storage and the reference file. A file system command is used to transmit the delta file to the target storage file system store to store in a directory of the target storage file system, wherein the file in the local storage is replicated at the target storage by a combination of the base file and the delta file.

Abstract translation: 提供了一种用于复制文件的方法，系统和程序。 将文件复制到作为基本文件存储的目标存储文件系统。 在本地存储器中生成包含复制文件的参考文件。 更新应用于本地存储的文件。 生成增量文件，指示本地存储器上的更新文件与参考文件之间的差异。 文件系统命令用于将增量文件传送到目标存储文件系统存储以存储在目标存储文件系统的目录中，其中本地存储器中的文件通过基本文件的组合在目标存储器处复制 和delta文件。

公开(公告)号：US20060040999A1

公开(公告)日：2006-02-23

申请号：US11173295

申请日：2005-07-01

Applicant: Amjad Ali ,  Joann Napolitano ,  Qiaolin Deng ,  Zhijian Lu ,  Peter Sinclair ,  Gayle Taylor ,  Christopher Thompson ,  Nazia Quraishi ,  Cameron Smith ,  Julianne Hunt ,  Adrian Dowst ,  Yi-Heng Chen ,  Hong Li

Inventor： Amjad Ali ,  Joann Napolitano ,  Qiaolin Deng ,  Zhijian Lu ,  Peter Sinclair ,  Gayle Taylor ,  Christopher Thompson ,  Nazia Quraishi ,  Cameron Smith ,  Julianne Hunt ,  Adrian Dowst ,  Yi-Heng Chen ,  Hong Li

IPC: A61K31/421 ,  C07D263/16

CPC classification number: C07F7/10 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/4168 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D207/26 ,  C07D207/27 ,  C07D233/32 ,  C07D233/38 ,  C07D233/50 ,  C07D233/52 ,  C07D263/04 ,  C07D263/20 ,  C07D263/22 ,  C07D263/24 ,  C07D263/26 ,  C07D285/06 ,  C07D285/10 ,  C07D401/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

Abstract: Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a —CH2—.

Abstract translation: 具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于升高HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。在式I化合物中，B或 R 2是具有邻芳基，杂环，苯并杂环或苯并环烷基取代基的苯基，并且在5元环上的另一个位置具有直接连接的芳族，杂环，环烷基，苯并杂环或苯并环烷基取代基 通过-CH 2 - 2连接到环上或连接到环上。

公开(公告)号：US20060035148A1

公开(公告)日：2006-02-16

申请号：US10527638

申请日：2003-09-11

Applicant: Palani Balaya ,  Hong Li ,  Joachim Maier

Inventor： Palani Balaya ,  Hong Li ,  Joachim Maier

IPC: H01M4/58 ,  H01M4/62

CPC classification number: H01M4/485 ,  H01M4/622 ,  H01M4/624 ,  H01M10/052 ,  H01M2004/021 ,  H01M2300/0082 ,  H01M2300/0085

Abstract: The description relates to the use of at least one transition metal halide with a binder, e.g. at least one of PVDF, PTFE, PAN and ETDM and optionally with at least one conductive additive such as carbon black, graphite, metal powder and metal fibres as an electrode in an Li-based electrochemical energy storage device. Further electrode materials are also described based on ruthenium oxide, molybdenum oxide, a nano-composite composed of transition metal and lithium fluoride or lithium oxide clusters with a typical grain size of 1-10 mm.

Abstract translation: 该描述涉及至少一种过渡金属卤化物与粘合剂的使用，例如， PVDF，PTFE，PAN和ETDM中的至少一种，并且任选地具有至少一种导电添加剂，例如在基于Li的电化学能量存储装置中作为电极的炭黑，石墨，金属粉末和金属纤维。 还描述了另外的电极材料，其基于氧化钌，氧化钼，由过渡金属和具有1-10mm典型晶粒尺寸的氟化锂或氧化锂簇组成的纳米复合物。

公开(公告)号：US06986012B2

公开(公告)日：2006-01-10

申请号：US10233450

申请日：2002-09-03

Applicant: Hong Li ,  Nicolaas Lambert ,  Robert Jochemsen ,  Rudi Jozef Marie Wijnands ,  Ozcan Mesut

Inventor： Hong Li ,  Nicolaas Lambert ,  Robert Jochemsen ,  Rudi Jozef Marie Wijnands ,  Ozcan Mesut

IPC: G06F12/00

CPC classification number: G11B20/10527 ,  G06F3/061 ,  G06F3/0619 ,  G06F3/0659 ,  G06F3/0676 ,  G06F11/00

Abstract: The invention relates to a method of writing data to and reading data from a memory (102) by a host. By limiting processing time, time restrictions regarding the data to be processed can be met. However, this is at the expense of data integrity. By setting time limits for a group (300) of multiple processing assignments and dynamic allocation of time, reserved for error recovery and retries, data integrity can be improved, while time limits can still be met. Furthermore, by attaching priorities to the assignments, multiple types of data can be handled in one group of assignments. For example, assignments with real-time requirements can be put in a group with assignments with best effort requirements. In this way, more flexible planning of processing assignments is possible. The invention also relates to a system for writing data to and reading data from a memory.

Abstract translation: 本发明涉及一种向主机向存储器（102）写入数据并从其读取数据的方法。 通过限制处理时间，可以满足关于要处理的数据的时间限制。 但是，这是牺牲数据完整性。 通过为多个处理分配的组（300）设置时间限制和动态分配时间，保留用于错误恢复和重试，可以提高数据完整性，同时可以满足时间限制。 此外，通过将优先级附加到分配，可以在一组分配中处理多种类型的数据。 例如，具有实时要求的分配可以放在具有尽力而为要求的分配的组中。 以这种方式，可以进行更灵活的处理分配计划。 本发明还涉及一种用于将数据写入和从存储器读取数据的系统。

公开(公告)号：US06909549B1

公开(公告)日：2005-06-21

申请号：US10384122

申请日：2003-03-06

Applicant: Yung-Chieh Hsieh ,  Chiayu Ai ,  Hong Li ,  Dar-Yuan Song

Inventor： Yung-Chieh Hsieh ,  Chiayu Ai ,  Hong Li ,  Dar-Yuan Song

IPC: G02B6/34 ,  G02B27/00

CPC classification number: G02B6/29383 ,  G02B6/2713 ,  G02B6/2766 ,  G02B6/29367 ,  G02B6/29395

Abstract: A tunable filter includes a polarizing beam splitter and a half-wave plate that produce two equally polarized beams from an arbitrarily polarized input light. The polarized beams are directed toward a tunable component that consists of an optical substrate coated with a filter and a reflective element on its back and front surface, respectively. The pass and stop beams emerging from the tunable component are retro-reflected by roof structures and passed again through the filter. As a result of this combination of components, the filter's performance is not dependent on polarization and the filter's output channels are not shifted or deviated by tuning.

Abstract translation: 可调滤波器包括偏振分束器和半波片，其从任意偏振的输入光产生两个等偏振光束。 偏振光束分别指向可调组件，该可调组件由分别在其背面和前表面上涂覆有过滤器和反射元件的光学衬底组成。 从可调组件出来的通过和停止梁被屋顶结构反射，并再次通过过滤器。 由于组件的这种组合，滤波器的性能不依赖于极化，并且滤波器的输出通道不会通过调谐偏移或偏移。

公开(公告)号：US06638502B1

公开(公告)日：2003-10-28

申请号：US09403736

申请日：2000-06-29

Applicant: Hong Li ,  He Lu ,  Frank Griscelli ,  Paule Opolon ,  Claudine Soria ,  Thierry Ragot ,  Yves Legrand ,  Jeannette Soria ,  Christelle Mabilat ,  Michel Perricaudet ,  Patrice Yeh

Inventor： Hong Li ,  He Lu ,  Frank Griscelli ,  Paule Opolon ,  Claudine Soria ,  Thierry Ragot ,  Yves Legrand ,  Jeannette Soria ,  Christelle Mabilat ,  Michel Perricaudet ,  Patrice Yeh

IPC: A61K4800

CPC classification number: A61K38/49 ,  A61K38/484 ,  A61K48/00 ,  C12N2799/022

Abstract: The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.

Abstract translation: 本发明涉及用于治疗肿瘤的基因治疗。 本发明更具体地涉及将编码抗血管生成因子的基因导入肿瘤细胞，例如用有缺陷的腺病毒载体，抑制肿瘤的生长或转移或两者。 在具体实施方案中，表达尿激酶（ATF）的氨基末端片段的缺陷型腺病毒的递送抑制肿瘤的生长和转移。 这些作用与注射部位内和附近的新生血管形成的显着抑制相关。 递送表达血管抑素的三环酮1〜3的有缺陷的腺病毒载体抑制肿瘤生长和致瘤性，并诱导肿瘤细胞凋亡。 本发明还提供了用于本发明方法的病毒载体。

公开(公告)号：US06621714B1

公开(公告)日：2003-09-16

申请号：US10001103

申请日：2001-11-02

Applicant: Hong Li ,  Kenneth S. Laughlin ,  Craig G. Mitchell ,  Thomas C. Ruberto

Inventor： Hong Li ,  Kenneth S. Laughlin ,  Craig G. Mitchell ,  Thomas C. Ruberto

IPC: H05K714

CPC classification number: G02B6/4471 ,  F16L3/23 ,  G02B6/3616 ,  H05K3/301

Abstract: An apparatus and method for retaining a length of fiber optic cable to a circuit board includes a body portion. The body portion of the apparatus includes at least a pair of spaced legs extending from the body portion, each of the legs is adapted to be received in a mounting opening formed in the PC board. Each of the spaced legs includes a foot portion adapted for securing the body to the circuit board and at least a pair of spaced arms extend from the body portion defining a slot between the arm and the body portion for receiving and retaining a portion of the length of fiber optic cable. The arms are spaced a distance from each other for retaining the fiber optic cable in an arc having a radius greater than a minimum bend radius of the fiber optic cable.

Abstract translation: 用于将一段光纤电缆保持在电路板上的装置和方法包括主体部分。 装置的主体部分至少包括一对从主体部分延伸的间隔开的腿，每个腿适于容纳在形成在PC板中的安装开口中。 每个间隔开的腿包括适于将本体固定到电路板的脚部分，并且至少一对隔开的臂从主体部分延伸，该主体部分在臂和主体部分之间限定狭槽，用于接收和保持长度的一部分 的光缆。 臂彼此隔开一段距离，以将光纤电缆保持在具有大于光纤电缆的最小弯曲半径的半径的弧度中。

公开(公告)号：US06537271B1

公开(公告)日：2003-03-25

申请号：US09611240

申请日：2000-07-06

Applicant: David R. Murray ,  Hong Li

Inventor： David R. Murray ,  Hong Li

IPC: A61B1818

CPC classification number: A61B18/02 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0268

Abstract: A method and apparatus for inflating a balloon at a distal portion of an elongated delivery catheter to contact surrounding biological tissue, and expanding a refrigerant adjacent the balloon to cool the biological tissue to render it non-viable. The inflation of the balloon can be accomplished with the expanded refrigerant or with a separate pressurized fluid. The balloon can act as a heat transfer element, or there can be a separate heat transfer element on the catheter adjacent the balloon. The apparatus can be used to perform a dilation procedure, such as angioplasty, in conjunction with cooling of the surrounding tissue.

Abstract translation: 一种用于在细长输送导管的远端部分处使球囊膨胀以接触周围生物组织的方法和装置，以及使邻近球囊的致冷剂膨胀以冷却生物组织以使其不可行。 球囊的膨胀可以用膨胀的制冷剂或单独的加压流体来实现。 球囊可以用作传热元件，或者在导管上可以有与气囊相邻的单独的传热元件。 该装置可用于执行扩张程序，例如血管成形术，结合周围组织的冷却。

公开(公告)号：US06407884B1

公开(公告)日：2002-06-18

申请号：US09292762

申请日：1999-04-14

Applicant: John R. Osborne ,  Hong Li ,  John Berg ,  David Kindler

Inventor： John R. Osborne ,  Hong Li ,  John Berg ,  David Kindler

IPC: G11B517

CPC classification number: B82Y10/00 ,  G11B5/17 ,  G11B5/40 ,  G11B7/1372 ,  G11B7/22 ,  G11B11/10534 ,  G11B11/10554 ,  G11B11/1058 ,  G11B33/14 ,  Y10S359/90 ,  Y10T156/109

Abstract: An optical recording head is provided which includes a slider body having a leading edge. A void is formed in the slider body to receive a sphere of optically transparent material. The sphere is inserted into the void such that a portion of the sphere protrudes from the slider body. The protruding portion is lapped to be coplanar with a surface of the slider body to form a near-field lens. A mesa may be formed onto the lapped portion and may include a coil. The slider body, mesa, near-field lens, and coil may be formed in one batch process.

Abstract translation: 提供了一种光学记录头，其包括具有前缘的滑块体。 在滑块体中形成空隙以容纳光学透明材料球。 将球体插入到空隙中，使得球体的一部分从滑块体突出。 凸出部分被重叠以与滑块体的表面共面以形成近场透镜。 可以在研磨部分上形成台面，并且可以包括线圈。 滑块体，台面，近场透镜和线圈可以以一个批次的方式形成。