公开(公告)号：US20200002677A1

公开(公告)日：2020-01-02

申请号：US16456127

申请日：2019-06-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan KWON ,  Sun Hwa KIM ,  Yoosoo YANG ,  Hyosuk KIM

IPC: C12N5/077

Abstract: The present invention relates to a method for inducing trans-differentiation of cardiomyocytes based on exosome, and more particularly, to a method for inducing trans-differentiation of a fibroblast into a cardiomyocyte, comprising the steps of: isolating exosomes in a culture medium during a process of differentiating a stem cell into the cardiomyocyte; culturing a fibroblast in a cardiomyocyte reprogramming medium containing the isolated exosomes; and culturing the fibroblast cultured in a cardiomyocyte differentiation medium containing the isolated exosomes.

公开(公告)号：US10519490B2

公开(公告)日：2019-12-31

申请号：US15499005

申请日：2017-04-27

Applicant: Korea Institute of Science and Technology

Inventor： Sang Kyung Kim ,  Seungwon Jung

IPC: C12Q1/68 ,  C12Q1/6853 ,  C12Q1/686

Abstract: A porous matrix according to the present disclosure, wherein a nucleic acid primer-carbon material composite in which one or more nucleic acid primer of a forward primer and a reverse primer as a polymerase chain reaction (PCR) primer is bound to a carbon material is included in the pores of the matrix, provides improved amplification efficiency as compared to a matrix wherein the nucleic acid primer is present on the outer surface of the matrix or a porous matrix wherein the nucleic acid primer is directly fixed inside pores. The porous matrix of the present disclosure can effectively detect various kinds of target nucleic acids simultaneously and analyze them in real time by varying the kinds of the nucleic acid primers included in the matrix. Therefore, it is useful in amplifying multiple nucleic acids.

公开(公告)号：US20190381122A1

公开(公告)日：2019-12-19

申请号：US16555950

申请日：2019-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/00 ,  A23L33/105

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

公开(公告)号：US20190369407A1

公开(公告)日：2019-12-05

申请号：US16174015

申请日：2018-10-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sungkyu KIM ,  Kihyuk YOON

IPC: G02B27/22

Abstract: Provided is an autostereoscopic three-dimensional image display apparatus. The autostereoscopic three-dimensional image display apparatus includes a display panel including an array of a plurality of sub-pixels, and an optical plate or a line light source, which is spaced a predetermined interval from the display panel at a predetermined inclination angle, wherein an inclination angle of the optical plate or the line light source with respect to a vertical direction of the display panel is determined by an equation.

公开(公告)号：US10483550B2

公开(公告)日：2019-11-19

申请号：US15630471

申请日：2017-06-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyung Joong Yoon ,  Seung-Hwan Lee ,  Mansoo Park ,  Jongsup Hong ,  Hyoungchul Kim ,  Ji-Won Son ,  Jong Ho Lee ,  Byung Kook Kim ,  Hae-Weon Lee

IPC: H01M4/88 ,  H01M4/90 ,  H01M8/12 ,  H01M8/1253 ,  H01M8/124

Abstract: Provided is a solid oxide cell including a fuel electrode layer, electrolyte layer and an air electrode layer, wherein a diffusion barrier layer is provided between the air electrode layer and the electrolyte layer, the diffusion barrier layer includes: a first diffusion barrier layer formed on the electrolyte layer and including a sintered ceria-based metal oxide containing no sintering aid; and a second diffusion barrier layer formed on the first diffusion barrier layer and including a sintered product of a ceria-based metal oxide mixed with a sintering aid, the first diffusion barrier layer includes a sintered product of nanopowder and macropowder of a ceria-based metal oxide, and the first diffusion barrier layer and the second diffusion barrier layer are sintered at the same time. The diffusion barrier layer is densified, shows high interfacial binding force and prevents formation of a secondary phase derived from chemical reaction with the electrolyte.

公开(公告)号：US10481188B2

公开(公告)日：2019-11-19

申请号：US15874415

申请日：2018-01-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Minah Seo ,  Sanghun Lee ,  Chulki Kim ,  Q-Han Park ,  Jongho Choe ,  Jinsoo Kim

IPC: G01R27/00 ,  G01R27/26 ,  G01N21/3563

Abstract: Disclosed herein is a system for non-contact measurement of an optoelectronic property. The system includes a sensing element configured to amplify an electromagnetic wave having a specific frequency, a thin film disposed on the sensing element such that an optoelectronic property of the thin film is measured, and an optoelectronic property measuring server configured to extract a physical property of the thin film based on the optoelectronic property of the thin film obtained when the electromagnetic wave amplified by the sensing element passes through the thin film.

公开(公告)号：US20190341624A1

公开(公告)日：2019-11-07

申请号：US16268856

申请日：2019-02-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jong Hyun JANG ,  Hee-Young PARK ,  Jea-woo JUNG ,  Hyoung-Juhn KIM ,  Dirk HENKENSMEIER ,  Sung Jong YOO ,  Jin Young KIM ,  So Young LEE ,  Hyun Seo PARK

IPC: H01M4/92

Abstract: The present disclosure relates to a method for preparing a carbon-supported platinum-transition metal alloy nanoparticle catalyst. More particularly, the present disclosure provides a method for preparing a carbon-supported platinum-transition metal alloy nanoparticle catalyst using a stabilizer, the method including the steps of: (a) mixing a platinum precursor, a transition metal precursor, carbon, stabilizer and a reducing agent solution, and carrying out washing and drying to obtain carbon-supported platinum-transition metal alloy nanoparticles; (b) mixing the carbon-supported platinum-transition metal alloy nanoparticles with an acetic acid solution, and carrying out washing and drying to obtain acetic acid-treated nanoparticles; and (c) heat treating the acetic acid-treated nanoparticles. Thus, it is possible to obtain a carbon-supported platinum-transition metal alloy nanoparticle catalyst through a more simple and eco-friendly process as compared to the related art, and to apply the catalyst to a high-performance and high-durability fuel cell catalyst.

公开(公告)号：US20190321972A1

公开(公告)日：2019-10-24

申请号：US16168048

申请日：2018-10-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jung Hoon KIM ,  Jaeyoung PARK

IPC: B25J9/16

Abstract: Provided is a controller of a robot manipulator, a performance analysis method thereof and a parameter determination method thereof. The controller computes an error value of an output value of a control target for a target value through a computational equation and provides a control input value of the control target, and includes an outer loop controller which constitutes closed loop control of the control target, and an inner loop controller which performs feedback linearization to remove nonlinearity of the control target, wherein the computational equation is a linear differential equation designed considering exogenous disturbance acting in the controller and a computational error.

公开(公告)号：US10435296B2

公开(公告)日：2019-10-08

申请号：US15713698

申请日：2017-09-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chang Won Yoon ,  Dajung Han ,  Yeong Cheon Kim ,  Hyun Seo Park ,  Hyung Chul Ham ,  Sung Pil Yoon ,  Jonghee Han ,  Tae Hoon Lim ,  Suk Woo Nam

IPC: C01B3/00 ,  C01B3/54 ,  C07C15/16 ,  B01J23/44 ,  B01J23/46 ,  C07C15/14 ,  C07C5/42 ,  B01J35/00 ,  B01J21/04 ,  B01J27/26 ,  C01B3/22

Abstract: Provided is a liquid hydrogen storage material including 1,1′-biphenyl and 1,1′-methylenedibenzene, the liquid hydrogen storage material including the corresponding 1,1′-biphenyl and 1,1′-methylenedibenzene at a weight ratio of 1:1 to 1:2.5. The corresponding liquid hydrogen storage material has excellent hydrogen storage capacity value by including materials having high hydrogen storage capacity, and is supplied in a liquid state, and as a result, it is possible to minimize initial investment costs and the like required when the corresponding liquid hydrogen storage material is used as a hydrogen storage material in a variety of industries.

公开(公告)号：US20190278567A1

公开(公告)日：2019-09-12

申请号：US16335039

申请日：2017-09-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Wook HAN ,  Sung Wook MOON ,  Yong Su KIM ,  Byung Kwon PARK

IPC: G06F7/58 ,  G06F16/51 ,  H04N5/374 ,  H04N5/372 ,  H04N5/357

Abstract: The present invention provides a random number generation system comprising: an image sensor module for outputting dark noise generated from each unit pixel region respectively that is shielded from external light as digital data; and a control unit for classifying the respective pieces of digital data output from the image sensor module, for allocating random numbers to the same using a database in which a plurality of reference values are stored for each unit pixel, and for collating the same so as to generate a first random number.