公开(公告)号：US4760068A

公开(公告)日：1988-07-26

申请号：US871386

申请日：1986-06-06

Applicant: Shinji Terao ,  Kohei Nishikawa

Inventor： Shinji Terao ,  Kohei Nishikawa

IPC: C07C51/363 ,  C07D201/08 ,  C07D213/26 ,  C07D213/30 ,  C07D213/32 ,  C07D213/50 ,  C07D213/55 ,  C07D213/57 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07F9/54 ,  A61K31/44 ,  C07D401/06

CPC classification number: C07D213/30 ,  C07C51/363 ,  C07D201/08 ,  C07D213/26 ,  C07D213/32 ,  C07D213/50 ,  C07D213/55 ,  C07D213/57 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07F9/5407

Abstract: Novel compound of the formula: ##STR1## wherein R.sup.1 is pyridyl group, R.sup.2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R.sup.3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R.sup.4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of accelerating the productivility of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

公开(公告)号：US4731454A

公开(公告)日：1988-03-15

申请号：US55380

申请日：1987-05-29

Applicant: Masayuki Otake ,  Isamu Fukushima

Inventor： Masayuki Otake ,  Isamu Fukushima

IPC: C07D201/08 ,  C07D207/26 ,  C07D207/267 ,  C07D207/12

CPC classification number: C07D207/267 ,  C07D201/08

Abstract: A method for producing a lactam having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, or a straight chain or branched chain alkyl group having from 1 to 5 carbon atoms, and R.sup.2 is an organic group having at least 2 carbon atoms, and connected at both ends to the cyclic acid imide group, which comprises reducing a cyclic acid imide having the formula: ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, or its precursor, with hydrogen by means of a cobalt-based catalyst comprising (a) cobalt and (b) at least one modifier component selected from the group consisting of molybdenum, tungsten and rhenium.

Abstract translation: 一种制备具有下式的内酰胺的方法：其中R1是氢原子，或具有1至5个碳原子的直链或支链烷基，R2是具有至少2个碳原子的有机基团 碳原子，并且两端连接到环状酰亚胺基团，其包括用氢气还原具有下式的其中R1和R2如上所定义的环状酰亚胺或其前体，其中通过 钴基催化剂，其包含（a）钴和（b）至少一种选自钼，钨和铼的改性剂组分。

公开(公告)号：US4731445A

公开(公告)日：1988-03-15

申请号：US007585

申请日：1987-01-28

Applicant: Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester

Inventor： Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester

IPC: B01J23/00 ,  B01J23/74 ,  B01J23/78 ,  B01J25/00 ,  C07B61/00 ,  C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: Caprolactam is prepared by a process in which(a) the 5-formylvalerate is reacted with excess ammonia and hydrogen in the presence of an alkanol as the solvent and in the presence of a hydrogenation catalyst under superatmospheric pressure in the liquid phase at from 40.degree. to 130.degree. C.,(b) excess ammonia and hydrogen are separated off from the reaction mixture,(c) the resulting reaction mixture is reacted with water at elevated temperatures with simultaneous removal of alkanols, and(d) the reaction mixture thus obtained is heated to 150.degree.-370.degree. C. and .epsilon.-caprolactam is obtained.

Abstract translation: 己内酰胺通过以下方法制备：其中（a）5-烷基戊酸酯与过量的氨和氢在作为溶剂的链烷醇存在下和氢化催化剂存在下，在超大气压下在40℃的液相中反应 （b）从反应混合物中分离出过量的氨和氢，（c）将所得的反应混合物在高温下与水反应，同时除去链烷醇，和（d）由此得到的反应混合物 加热至150-370℃，得到ε-己内酰胺。

公开(公告)号：US4730041A

公开(公告)日：1988-03-08

申请号：US7789

申请日：1987-01-28

Applicant: Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester ,  Heinz-Walter Schneider ,  Wolfgang Richter

Inventor： Hans-Martin Hutmacher ,  Franz Merger ,  Franz J. Broecker ,  Rolf Fischer ,  Uwe Vagt ,  Wolfgang Harder ,  Claus-Ulrich Priester ,  Heinz-Walter Schneider ,  Wolfgang Richter

IPC: B01J23/74 ,  B01J23/78 ,  B01J25/00 ,  C07B61/00 ,  C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: Caprolactam is prepared by a process in which(a) a 5-formylvalerate is reacted with excess ammonia and hydrogen in the presence of an alkanol as a solvent and in the presence of a hydrogenation catalyst under superatmospheric pressure in the liquid phase at from 40.degree. to 130.degree. C.,(b) excess ammonia and hydrogen are separated off from the reaction mixture and(c) the reaction mixture thus obtained is heated to 150.degree.-250.degree. C. and .epsilon.-caprolactam is obtained.

Abstract translation: 己内酰胺通过以下方法制备：其中（a）5-烷基戊酸酯与过量的氨和氢在烷醇作为溶剂的存在下和氢化催化剂的存在下在超大气压下在40℃的液相中反应 至130℃，（b）从反应混合物中分离出过量的氨和氢，（c）将所得反应混合物加热至150-250℃，得到ε-己内酰胺。

公开(公告)号：US4152331A

公开(公告)日：1979-05-01

申请号：US898214

申请日：1978-04-18

Applicant: Peter J. N. Meijer ,  Leonardus H. Geurts

Inventor： Peter J. N. Meijer ,  Leonardus H. Geurts

IPC: C07D207/267 ,  C07D201/08 ,  C07D207/26

CPC classification number: C07D201/08

Abstract: A process is described for preparing N-substituted pyrrolidones from succinonitriles by hydrogenation and hydrolysis.

公开(公告)号：US3988319A

公开(公告)日：1976-10-26

申请号：US506148

申请日：1974-09-16

Applicant: Frantisek Mares

Inventor： Frantisek Mares

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: Caprolactam is obtained in high yield and in short reaction time by completely dissolving 6-aminocaproic acid in methanol or ethanol and heating the solution at 170.degree.-200.degree. C.

Abstract translation: 通过将6-氨基己酸完全溶解在甲醇或乙醇中并在170-200℃下加热溶液，以高产率和短的反应时间获得己内酰胺。

公开(公告)号：US3944559A

公开(公告)日：1976-03-16

申请号：US395307

申请日：1973-09-07

Applicant: Martin Cherubim ,  Faisal Abodagga

Inventor： Martin Cherubim ,  Faisal Abodagga

IPC: C07D201/08 ,  C07D211/86 ,  C07D211/30

CPC classification number: C07D201/08 ,  C07D211/86

Abstract: Alkyl-substituted unsaturated .delta.-lactams are obtained by contacting monocyanoethylated ketones with an aqueous acid solution and permitting them to react. Alkyl-substituted unsaturated .delta.-lactams of this invention are valuable intermediate products useful for organic synthesis in the production of pharmaceuticals and plastics.

Abstract translation: 烷基取代的不饱和β-内酰胺是通过使单乙基乙烯基酮与酸水溶液接触并使其反应而获得的。 本发明的烷基取代的不饱和的β-内酰胺是有用的中间产物，可用于生产药物和塑料中的有机合成。

公开(公告)号：US3857510A

公开(公告)日：1974-12-31

申请号：US28568172

申请日：1972-09-01

Applicant: ALLIED CHEM

Inventor： ROGIC M ,  FUHRMANN R

IPC: C07D201/08 ,  C07D53/06

CPC classification number: C07D201/08

Abstract: A method of cleaving ketones at a carbon-carbon bond adjacent to the ketonic carbon to produce a terminal carboxylic ester and a terminal oxime group, which comprises, nitrosating the ketone in the presence of a polar aprotic solvent and an alcohol. The products are useful intermediates, particularly as intermediates in the production of polyamides, and as solvents. A method of synthesizing Epsilon -caprolactam from the intermediate omega hydroximino hexanoate, produced by cleaving cyclohexanone, hydrogenating the intermediate omega -aminohexanoate ester and cyclizing the corresponding ester thus formed, to Epsilon caprolactam.

Abstract translation: 一种在与碳酮碳相邻的碳 - 碳键处切割酮的方法，以产生末端羧酸酯和末端肟基，其包括在极性非质子溶剂和醇的存在下亚硝化酮。 该产品是有用的中间体，特别是作为生产聚酰胺和作为溶剂的中间体。 通过裂解环己酮，氢化中间体ω-氨基己酸酯并将由此形成的相应的酯环化为ε-己内酰胺从中间体ω-羟肟基己酸酯合成ε-己内酰胺的方法。

公开(公告)号：US3681387A

公开(公告)日：1972-08-01

申请号：US3681387D

申请日：1970-10-16

Applicant: SUN OIL CO

Inventor： HOLLSTEIN ELMER J ,  SCOTT KENNETH A

IPC: C07D201/02 ,  C07D201/08 ,  C07D27/08

CPC classification number: C07D201/02 ,  C07D201/08

Abstract: An improved process for preparing 2-pyrrolidinone at relatively low pressures which comprises reduction of succinimide in an aqueous system at temperatures of about 225* to 275* C., at a pressure in the range of about 1,200 to 1,500 p.s.i.g. and in the presence of a supported palladium catalyst.

Abstract translation: 一种用于在相对低的压力下制备2-吡咯烷酮的改进方法，其包括在约225-275℃的温度下在水性体系中还原琥珀酰亚胺，压力范围为约1,200至1,500p.s.i。 并在负载型钯催化剂存在下进行。

公开(公告)号：US3655748A

公开(公告)日：1972-04-11

申请号：US3655748D

申请日：1969-04-29

Applicant: BOSNALIJEK

Inventor： TANDARA MILAN

IPC: C10B27/04 ,  C07C101/04 ,  C07C99/06

CPC classification number: C07D201/08

Abstract: E-AMINOCAPROIC ACID IS PRODUCED BY THE HYDROLYTIC DECOMPOSITION OF E-CAPROLACTAM WHEREIN A MIXTURE OF THE LACTAM AND BA(OH)2$8H2O IS DISSOLVED IN A MIXED SOLVENT CONSISTING OF WATER AND DIMETHYLSULFOXIDE (DMSO). THE BARIUM SALT OF THE ACID WHICH IS FORMED IS THEN CONVERTED TO THE FREE ACID BY ADDING GASEOUS CARBON DIOXIDE WHICH FORMS INSOLUBLE BACO3.