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公开(公告)号：US20220220165A1
公开(公告)日：2022-07-14
申请号：US17611949
申请日：2020-05-25
Applicant: KOWA COMPANY, LTD.
Inventor： Takeshi DOI , Hideo YOSHIDA
IPC: C07K14/435 , C12P21/02
Abstract: Provided is a gene expression reinforcement system for a recombinant bagworm fibroin H chain protein. The system includes a gene encoding a modified recombinant bagworm fibroin H chain protein in which either the N-terminal domain or the C-terminal domain constituting the recombinant bagworm fibroin H chain protein has been partially or entirely deleted.
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公开(公告)号：US11366336B2
公开(公告)日：2022-06-21
申请号：US16467473
申请日：2017-12-06
Applicant: Kowa Company, Ltd.
Inventor： Haruo Ishikawa
Abstract: To realize a toric ophthalmic lens including an edge that makes it possible to design a lens contributing to secondary cataract prevention without deteriorating a degree of freedom of lens design. The toric ophthalmic lens is a toric ophthalmic lens in which, in a top view of an optical portion, a substantially flat portion having a substantially fixed edge thickness of the optical portion is provided to overlap a steep meridian of a toric surface of the optical portion.
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公开(公告)号：US20220184058A1
公开(公告)日：2022-06-16
申请号：US17438309
申请日：2020-03-13
Applicant: National University Corporation Hamamatsu University School of Medicine , Kowa Company, Ltd.
Inventor： Naoki UNNO , Hiroki TANAKA , Tatsuro YATA , Takafumi KAYAMA , Keisuke INOUE , Kiyoshi TOYA
IPC: A61K31/4704 , A61K45/06 , A61P9/14
Abstract: The present invention addresses the problem of providing a therapeutic agent for an abdominal aortic aneurysm, the therapeutic agent making drug therapy possible.
The present invention provides a therapeutic agent for aortic aneurysm, the therapeutic agent having as active ingredients: (−)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these; and a statin.-
公开(公告)号：US20220162206A1
公开(公告)日：2022-05-26
申请号：US17440879
申请日：2020-03-30
Applicant: KOWA COMPANY, LTD.
Inventor： Gen WATANABE , Toshiharu MORIMOTO , Akira IWATA , Hirotaka SASAKI , Takahisa OGAMINO , Kosuke USUDA , Ayumu OKUDA , Hiroyuki ISHIWATA , Yuichiro TABUNOKI , Keigo NISHII
IPC: C07D471/04 , C07D519/00
Abstract: To provide a novel compound or a salt thereof or a solvate thereof, having a CSF-1R inhibitory activity and exhibiting antitumor effect.
An azaindole derivative of formula (I): wherein A represents a C6-10 aryl ring, an aromatic heterocycle, or an unsaturated heterocycle, and A optionally has one substituent or more same or different substituents; and R represents a C1-3 alkyl group or a saturated heterocyclic group, or a salt thereof or a solvate thereof.-
公开(公告)号：US20220096443A1
公开(公告)日：2022-03-31
申请号：US17418518
申请日：2019-12-27
Applicant: KOWA COMPANY, LTD.
Inventor： Shin SUGIMOTO , Akito MINAMIZONO , Chisa NISHIDA
IPC: A61K31/423 , A61K47/32 , A61K47/38
Abstract: Provided is a pharmaceutical composition containing pemafibrate, a salt thereof or a solvate thereof and having excellent homogeneity. The pharmaceutical composition is provided to contain the following components (A) and (B): (A) pemafibrate, a salt thereof or a solvate thereof; and (B) one or more selected from the group consisting of the following components (B-1) and (B-7): (B-1) an alkylcellulose and a salt thereof; and a (meth)acrylic acid-based polymer.
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Patent Agency Ranking
公开(公告)号：US20220095714A1
公开(公告)日：2022-03-31
申请号：US17275568
申请日：2019-09-13
Applicant: KOWA COMPANY, LTD.
Inventor： Takuji Iida , Itsuo Nagata , Yukihiro Hosoe
Abstract: [Problem to be Solved]
To provide a finger supporter capable of stabilizing hand joints of a wearer and reducing a load on any one finger from among five fingers.
[Solution]
The finger supporter includes: a first anchor portion 2 that is formed at an upper end 10a of a tubular fabric and causes the tubular fabric to be fastened to a forearm wrist portion of a wearer; a second anchor portion 3 that is formed to continue two points of a circling portion on the other end side of the tubular fabric and forms the circling portion into two opening portions 12a and 12b with different sizes; and a first support portion 4 that couples the second anchor portion 3 and the first anchor portion 2 and supports any one finger inserted into the smaller opening portion 12a from among five fingers.-
公开(公告)号：US20210372007A1
公开(公告)日：2021-12-02
申请号：US16957990
申请日：2018-12-18
Inventor： Taiyo YOSHIOKA , Tsunenori KAMEDA , Akimune ASANUMA , Hironori SASSA
Abstract: Developed and provided is a method of collecting a large amount of high-quality bagworm silk threads having no contaminant from bagworm nests in a convenient manner and at low cost. The habit of bagworms is utilized to allow a bagworm to build a nest using solvent-soluble substances or thermally meltable substances as nest materials, followed by dissolving or melting the nest materials to separate the nest material from the bagworm silk threads, whereby only pure bagworm silk threads constituting the bagworm nest can be obtained.
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公开(公告)号：US11107214B2
公开(公告)日：2021-08-31
申请号：US16609649
申请日：2018-04-27
Inventor： Norihiko Yokoi , Katsumi Yabusaki
Abstract: A method and device for evaluating the dynamics of a tear fluid layer to objectively and accurately evaluate breakdown of the tear fluid layer, which is a core mechanism of dry eye, are provided. The method includes a step of acquiring color information of each pixel in a predetermined region of a tear fluid layer interference fringe image, which is a moving image or a plurality of static images, a step of calculating a numerical value indicating the diversity of color from the acquired color information, a step of calculating the average value of the color information, and a step of calculating a coefficient of variation on the basis of the calculated numerical value indicating the diversity of color and the calculated average value of the color information. The coefficient of variation is used as an index for evaluating the dynamics of the tear fluid layer.
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公开(公告)号：US20210212561A1
公开(公告)日：2021-07-15
申请号：US16976375
申请日：2019-03-01
Applicant: KOWA COMPANY, LTD.
Inventor： Reiko ARITA , Katsumi YABUSAKI
Abstract: In classifying images by machine learning, provided are an image classification method, device, and program for classifying the image from which the feature difference is hardly detected, in particular, classifying the interference fringe image of tear fluid layer by the dry eye types. The method includes a step of acquiring a feature value from an interference fringe image of tear fluid layer for learning, a step of constructing a model for classifying an image from the feature value acquired from the interference fringe image of tear fluid layer for learning, a step of acquiring the feature value from an interference fringe image of tear fluid layer for testing, and a step of performing classification processing for classifying the interference fringe image of tear fluid layer for testing by types of dry eye using the model and the feature value acquired from the interference fringe image of tear fluid layer.
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公开(公告)号：US20210119736A1
公开(公告)日：2021-04-22
申请号：US17056480
申请日：2019-05-22
Applicant: KOWA COMPANY, LTD.
Inventor： Tomohisa Azegami , Kenichi Namiki
Abstract: A first communication unit 11 repeatedly transmits the same data signal as a transmitted data signal to a second communication unit 23 at shorter time intervals than an acknowledgement time in which an ACK signal is returned from the second communication unit 23 without any failure. As a result, even when the transmitted data signal is garbled in the middle of a transmission path due to noise, the second communication unit 23 can rapidly receive the repeatedly transmitted same data signal.
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