公开(公告)号：US20220010287A1

公开(公告)日：2022-01-13

申请号：US17467265

申请日：2021-09-05

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SYNVACCINE LTD.

Inventor： Tamir TULLER ,  Eli GOZ ,  Shimshi ATAR ,  Hadas ZUR

IPC: C12N7/00 ,  G16B99/00 ,  C12N7/04 ,  G16B15/10 ,  A61K39/12

Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

公开(公告)号：US20210315983A1

公开(公告)日：2021-10-14

申请号：US17092386

申请日：2019-05-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Yochai WOLF ,  Osnat BARTOK

IPC: A61K39/00 ,  A61P35/00 ,  C12N5/09 ,  G01N33/574

Abstract: A method of identifying a neoantigen in a tumor of a subject is disclosed. The method comprises:
(a) culturing cells of the tumor under conditions which generate single cell clones of the tumor; and
(b) analyzing the single cell clones for expression of a neoantigen which is reactive with T cells from the subject, thereby identifying the neoantigen in a tumor of a subject.

公开(公告)号：US20210293820A1

公开(公告)日：2021-09-23

申请号：US17334862

申请日：2021-05-31

Applicant: Yeda Research and Development Co. Ltd. ,  Stichting Het Nederlands Kanker Instituut - Antoni Van Leeuwenhoek Ziekenhuis

Inventor： Ido AMIT ,  Hanjie LI ,  Amos TANAY ,  Ido YOFE ,  Yaniv EYAL-LUBLING ,  Antonius Nicolaas Maria SCHUMACHER ,  Anne Magdalena VAN DER LEUN

IPC: G01N33/574 ,  C12N15/113 ,  G01N33/50

Abstract: Method of activating dysfunctional T cells, determining responsiveness of a subject having a tumor to an immune checkpoint inhibition are provided. Also provided is an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor. Additionally or alternatively provided is an immune checkpoint inhibitor and an agent capable of inhibiting a target gene or expression product thereof for use in treating a subject having a tumor.

公开(公告)号：US20210260139A1

公开(公告)日：2021-08-26

申请号：US17318009

申请日：2021-05-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K35/741 ,  C12Q1/689 ,  A23L33/00 ,  A23L33/105 ,  A61K31/352 ,  A61K35/74 ,  C12Q1/02 ,  A23L33/135 ,  A61P3/04

Abstract: A method of analyzing the likelihood of weight regain in a subject who has reached a target weight by practicing a weight loss program is disclosed. The method comprises determining an amount or presence of at least one microbe and/or product thereof in the gut microbiome of the subject, wherein the amount of the at least one microbe is altered during a prior weight gain period of the subject to reach a level representative of an obese subject and further wherein the amount of the at least one microbe is retained at the level following the weight loss program, wherein the amount or presence of the at least one microbe or product thereof is predictive of weight regain.

公开(公告)号：US20210238173A1

公开(公告)日：2021-08-05

申请号：US16972013

申请日：2019-06-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Nir LONDON ,  Amit SHRAGA ,  Evgenia OLSHVANG

IPC: C07D471/04 ,  C07D231/56 ,  C07D491/052 ,  C07D401/04

Abstract: Provided are compounds that act as covalent inhibitors of mitogen-activated protein kinase kinase 7 (MKK7 enzyme), method of preparation and uses thereof.

公开(公告)号：US20210221888A1

公开(公告)日：2021-07-22

申请号：US17186960

申请日：2021-02-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K38/00 ,  A61K38/14 ,  A61K45/06 ,  A61K31/404 ,  A61K31/7068 ,  A61K33/36 ,  A61K39/395 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K31/4155 ,  A61K38/02

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session.

公开(公告)号：US20210210648A1

公开(公告)日：2021-07-08

申请号：US17272946

申请日：2019-09-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ernesto JOSELEVICH ,  Eitan OKSENBERG ,  Regev BEN-ZVI ,  Jinyou XU ,  Mark SCHVARTZMAN ,  Lotem ALUS ,  Yonatan VERNIK

IPC: H01L31/0475 ,  H01L31/0224 ,  H01L31/0352 ,  H01L31/072 ,  H01L31/18

Abstract: This invention relates to photovoltaic devices such as photovoltaic cells and photodetectors. The invention provides processes for fabrication of the devices and methods of use thereof. The invention is further related to controlled growth of nanowire arrays using elongated shapes as guides on the surface.

公开(公告)号：US20210188977A1

公开(公告)日：2021-06-24

申请号：US17187011

申请日：2021-02-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K38/00 ,  A61K38/14 ,  A61K45/06 ,  A61K31/404 ,  A61K31/7068 ,  A61K33/36 ,  A61K39/395 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K31/4155 ,  A61K38/02

Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

公开(公告)号：US20210178207A1

公开(公告)日：2021-06-17

申请号：US17267816

申请日：2019-08-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Sarel FLEISHMAN ,  Dan S. TAWFIK ,  Olga KHERSONSKY

IPC: A62D3/02

Abstract: Provided herein is a library of designed phosphotriesterase (PTE) enzymes, exhibiting an improved catalytic hydrolysis activity of various substrates, including nerve agents, and a general method of generating and using the same.

公开(公告)号：US20210177920A1

公开(公告)日：2021-06-17

申请号：US16770432

申请日：2018-12-04

Applicant: BIOMX LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eyal Weinstock ,  Hava Ben-David ,  Kobi Konstantin Sudakov ,  Ayelet Moses ,  Sarah Rachel Pollock ,  Rotem Sorek ,  Naomi Bluma Zak

IPC: A61K35/76 ,  A61K9/00 ,  A61P17/10 ,  A61P31/04 ,  A61K45/06

Abstract: Bacteriophage compositions and therapeutic uses thereof. In particular, compositions of lytic bacteriophages that are capable of lysing Propionibacterium acnes (P. acnes) bacterial strains associated with acne and biofilms, thereby treating or preventing acne and biofilms.