公开(公告)号：US20150092811A1

公开(公告)日：2015-04-02

申请号：US14495244

申请日：2014-09-24

Applicant: Worcester Polytechnic Institute

Inventor： Ming Su

IPC: G01K11/06 ,  G06K19/06 ,  G01K17/00

CPC classification number: G01K11/06 ,  G01K17/00 ,  G06K19/06 ,  Y10S977/90

Abstract: Coding systems may include an object and a taggant linked to the object, the taggant comprising one or more types of phase change nanoparticles, each type of phase change nanoparticles having a phase change temperature different from a phase change temperature of other types of phase change nanoparticles, wherein, when the taggant is thermally scanned, different phase change temperatures result in one or more predefined melting peaks forming a code that represents information particular to the object.

Abstract translation: 编码系统可以包括连接到对象的物体和标签剂，标签剂包括一种或多种类型的相变纳米颗粒，每种类型的相变纳米颗粒具有与其它类型的相变纳米粒子的相变温度不同的相变温度 其中当标签剂被热扫描时，不同的相变温度导致一个或多个预定义的熔融峰形成表示对象特有的信息的代码。

公开(公告)号：US20150025009A1

公开(公告)日：2015-01-22

申请号：US14445930

申请日：2014-07-29

Applicant: WORCESTER POLYTECHNIC INSTITUTE

Inventor： Kevin G. Cornwell ,  George D. Pins ,  Kristen Billiar

IPC: A61K38/36

CPC classification number: A61L27/225 ,  A61K38/363 ,  A61L31/046 ,  A61L2300/252 ,  A61L2400/04 ,  A61L2430/34

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract translation: 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。

公开(公告)号：US20130102838A1

公开(公告)日：2013-04-25

申请号：US13693560

申请日：2012-12-04

Applicant: Worcester Polytechnic Institute

Inventor： Eric W. Overstrom ,  Elena Ibanez ,  Christine A. Lima

IPC: C12N15/877 ,  A61D19/04

CPC classification number: C12N15/8775 ,  A01K2217/05 ,  A01K2227/105 ,  A61D19/04 ,  C12N5/0609

Abstract: The invention pertains to the discovery that the presence of oocyte spindle associated factors in an enucleated oocyte improves oocyte quality and subsequently nuclear transfer. In particular, it was discovered that maintaining oocyte spindle factors in the oocyte after enucleation improves oocyte quality for use in nuclear transfer methodology.

Abstract translation: 本发明涉及以下发现：在去核卵母细胞中存在卵母细胞纺锤体相关因子改善了卵母细胞质量和随后的核转移。 特别是，发现在摘除卵母细胞后维持卵母细胞主轴因子改善了用于核转移方法的卵母细胞质量。

公开(公告)号：US20040099351A1

公开(公告)日：2004-05-27

申请号：US10668668

申请日：2003-09-23

Applicant: Worcester Polytechnic Institute

Inventor： Anacleto M. de Figueredo ,  Diran Apelian ,  Matt M. Findon ,  Nicholas Saddock

IPC: C22F001/04

CPC classification number: C21C7/00 ,  B22D17/007 ,  C22C1/005 ,  C22C1/02 ,  C22C1/03 ,  C22C1/06

Abstract: Described herein are alloys substantially free of dendrites. A method includes forming an alloy substantially free of dendrites. A superheated alloy is cooled to form a nucleated alloy. The temperature of the nucleated alloy is controlled to prevent the nuclei from melting. The nucleated alloy is mixed to distribute the nuclei throughout the alloy. The nucleated alloy is cooled with nuclei distributed throughout.

Abstract translation: 本文描述的是基本上不含树突的合金。 一种方法包括形成基本上不含枝晶的合金。 将过热合金冷却以形成有核合金。 控制有核合金的温度以防止细胞核熔化。 将有核合金混合以将核分布在整个合金中。 有核合金被冷却，核分布在整个过程中。

公开(公告)号：US20250120473A1

公开(公告)日：2025-04-17

申请号：US18912450

申请日：2024-10-10

Applicant: Worcester Polytechnic Institute

Inventor： Christopher A. Brown ,  David J. Kohanski ,  Katherine S. Rosivach ,  Henry D. Ball

IPC: A43B13/16 ,  A43B7/32 ,  A43B13/14

Abstract: A force absorbing device for a footwear appliance includes a shoe upper and a shoe sole having a planar sole surface, such that forces between the shoe upper and planar sole surface in ground contact are absorbed by storage and controlled release of kinetic energy in an elastic or resilient field. A footwear article such as a shoe or boot includes a split-sole system that redefines a shoe sole as coplanar surfaces having a force mitigating interface for receiving sudden forces and effectively mitigating these forces by storing kinetic energy and releasing it over time. An elastic field in the force mitigation interface is defined by a resilient material adapted to deform in response to the received force. Frictional engagement between the upper and lower sole may also be augmented by surface characteristics such as dimples, voids and lubricants, in addition to interference engagement with an elastic field.

公开(公告)号：US20240401062A1

公开(公告)日：2024-12-05

申请号：US18524554

申请日：2023-11-30

Applicant: Worcester Polytechnic Institute

Inventor： Natalie G. Farny ,  Solimar Ramis De Ayreflor Reyes ,  Afreen Anwar

IPC: C12N15/115 ,  A61K35/741 ,  A61K47/00 ,  A61P39/04

Abstract: An aptamer having an affinity for toxic metals such as lead is introduced by a biocompatible delivery mechanism such as a DNA or RNA strand to which the aptamer is attached. The delivery mechanism delivers the aptamer, either as a direct nucleic acid sequence or expressed in a cell as a probiotic. When delivered as a prophylactic to the gastrointestinal tract (orally) as an aptamer or expressed within a probiotic cell, this would prevent absorption of metals and would thus reduce or eliminate the need for chelation therapy and thereby reduce disease burden. When used therapeutically, it could be ingested, or injected intravenously. Once bound, the toxic metals are expelled through normal gastrointestinal or urinary processes.

公开(公告)号：US12145013B2

公开(公告)日：2024-11-19

申请号：US15475684

申请日：2017-03-31

Applicant: Worcester Polytechnic Institute

Inventor： Brian E. Elias ,  Robert G. Zalosh ,  Ali S. Rangwala ,  Samim Safaei Boroojeny ,  Larry Genovesi

IPC: A62C3/06 ,  A62C4/00

Abstract: A volatile liquid storage container has combustion resistance properties from a flexible sock or tube constructed of fire resistant fibers coupled to a neck of the storage container to prevent flame flash-back into the storage container. The storage container defines an enclosed volume having an orifice in the container material leading to a neck for pouring and filling the enclosed volume for exchanging the contents therein. The tube is elongated and surrounds a circumference of the orifice for engaging any ignition source entering through the orifice. The flexible nature of the tube or sock allows it to extend to an opposed interior surface of the enclosed volume, and ensures that the tube or sock is immersed in the fluid for encircling any ignition path to the volatile liquid without interfering with an ability to pour or refill the container.

公开(公告)号：US20240351954A1

公开(公告)日：2024-10-24

申请号：US18639498

申请日：2024-04-18

Applicant: Worcester Polytechnic Institute

Inventor： Nima Rahbar ,  Shuai Wang ,  Suzanne Scarlata

IPC: C04B35/52 ,  B28B11/24 ,  C04B35/626 ,  C04B35/64 ,  C12P3/00

CPC classification number: C04B35/52 ,  C04B35/6264 ,  C04B35/62655 ,  C04B35/64 ,  C12P3/00 ,  B28B11/24 ,  C04B2235/422 ,  C04B2235/442 ,  C04B2235/48 ,  C04B2235/5436 ,  C04B2235/6027 ,  C04B2235/606 ,  C04B2235/656

Abstract: A carbon-negative Engineering Structural Material (ESM) has a compressive strength approaching that of concrete and relies on a carbon-absorbing enzyme for crystalline formations formed cooperatively with a porous structure to achieve load-bearing properties. A tough scaffold forms through capillary suspension, a technique that utilizes capillary forces to concentrate particles in a liquid matrix. Carbonic anhydrase, a zinc-containing enzyme extracted from bovine erythrocytes, is harnessed to grow mineral materials, and the capillary suspension is used to create a construction material, including sand and a polymer. This combination enables the incorporation of precipitated calcium minerals into the structure, resulting in the development of water-resistant and load-bearing construction materials.

公开(公告)号：US12082979B2

公开(公告)日：2024-09-10

申请号：US17499600

申请日：2021-10-12

Applicant: Worcester Polytechnic Institute

Inventor： Gregory S. Fischer ,  Benjamin Piecuch ,  Dino Kasvikis ,  Perry A. Genova

IPC: A61B90/14 ,  A61B17/00 ,  A61B34/00 ,  A61B34/20 ,  A61B34/30 ,  A61B50/13 ,  A61B90/00 ,  A61B90/50

CPC classification number: A61B90/14 ,  A61B34/20 ,  A61B34/25 ,  A61B2017/00199 ,  A61B34/30 ,  A61B50/13 ,  A61B90/37 ,  A61B90/50

Abstract: A surgical head clamp and robotics platform secures a head of a patient and positions an instrument relative to the head for a medical procedure. The head clamp and robotics platform comprises a planar C-shaped frame for at least partially encircling the head of a patient. An instrument arm is mounted is to a free distal end of one arm member of the frame. The instrument arm extends away from the arm member in a direction transverse to the plane of the frame. The instrument arm includes a base mounted to the arm member for movement along three degrees of freedom relative to the frame, a proximal portion extending from and pivotally connected to the base, and a distal instrument holder extending from and pivotally connected to the proximal portion. The instrument arm functions to selectively position the instrument in an angular position relative to the head clamp.

公开(公告)号：US20240278016A1

公开(公告)日：2024-08-22

申请号：US18581910

申请日：2024-02-20

Applicant: Worcester Polytechnic Institute

Inventor： Sergey N. Makaroff ,  Manas Rachh ,  Leslie Greengard ,  Laleh Golestani Rad

IPC: A61N1/36 ,  A61N1/05 ,  G16H20/40

CPC classification number: A61N1/36128 ,  A61N1/0534 ,  A61N1/36067 ,  G16H20/40

Abstract: A method for directing an electrostimulation therapy includes receiving a scan image of a treatment region and determining a purported location of a stimulation probe inserted within the scan image. A modeling application or computational engine determines a position of a target region within the scan image relative to the purported location, and computes a strength of the electrical energy at the position based on a Fast Multipole Method (FMM) using LU (Lower/Upper) factorization, and concludes an efficacy resulting from activation of an electrode delivering the electrical energy resulting from the stimulation probe at the purported location.