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    Automatic tract extraction via atlas based adaptive connectivity-based clustering
    22.
    发明授权
    Automatic tract extraction via atlas based adaptive connectivity-based clustering 有权

    公开(公告)号：US10881321B2

    公开(公告)日：2021-01-05

    申请号：US15229594

    申请日：2016-08-05

    Applicant: The Trustees of the University of Pennsylvania

    Inventor： Ragini Verma ,  Birkan Tunc

    IPC: A61B5/00 ,  A61B5/055 ,  G01R33/563

    Abstract: Method and apparatus for processing diffusion data for identification of white matter tracts in the brain of a patient is provided herein. The method involves, with a processor: generating a connectivity based representation of white matter fibers for multiple different subjects from the connectivity signatures of the fibers from a diffusion magnetic resonance imaging (dMRI) without using the physical coordinates of the fibers; generating a fiber bundle atlas from the connectivity based fiber representation of (a) which define a model of the human brain; adaptively clustering fibers of a new patient utilizing the fiber bundle atlas of (b) to extract white matter tracts without manual intervention in the form of drawing regions of interest; and presenting the selected white matter tracts and diffusion data in a report or on a display device. This method and apparatus can be used even for patients having edema or brain perturbations.

    Compositions and methods for self-regulated inducible gene expression
    24.
    发明授权
    Compositions and methods for self-regulated inducible gene expression 有权

    公开(公告)号：US10392622B2

    公开(公告)日：2019-08-27

    申请号：US15500591

    申请日：2015-07-31

    Applicant: The Trustees of the University of Pennsylvania

    Inventor： Mitchell Lewis ,  Jean Bennett ,  Luk Vandenberghe ,  Matthew Sochor ,  Theodore G. Drivas

    IPC: C12N15/63

    Abstract: A self-regulating gene expression construct comprises a single promoter in operative association with a repressor sequence (e.g., bacterial repressor lacI or gaiR), operator sequence(s) responsive to the expressed repressor protein, and a transgene. A dual-regulating construct comprises a single promoter controlling expression of a bacterial repressor sequence and a transgene, and which, in the presence of a first inducer molecule, transcribes the transgene and repressor; and a ribozyme in association with an aptamer sequence, the aptamer sequence capable of interacting with a second inducer molecule to terminate mRNA degradation by the ribozyme. Also provided are recombinant vectors or viruses containing the self-regulating or dual self-regulating constructs and cells containing the vectors. Such compositions are useful in methods of treating a diseases using gene therapy.

    Compositions comprising AAV expressing dual antibody constructs and uses thereof
    30.
    发明授权
    Compositions comprising AAV expressing dual antibody constructs and uses thereof 有权

    公开(公告)号：US10975140B2

    公开(公告)日：2021-04-13

    申请号：US16821295

    申请日：2020-03-17

    Applicant: The Trustees of the University of Pennsylvania

    Inventor： James M. Wilson ,  Anna Tretiakova

    IPC: C12N15/11 ,  A61K48/00 ,  C12N9/22 ,  C12N15/86 ,  C12N15/90 ,  C07K16/10 ,  C12N7/00 ,  A61K39/00

    Abstract: A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5′ and 3′ ITRs flank the expression cassettes and regulatory sequences.

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