公开(公告)号：US10993466B2

公开(公告)日：2021-05-04

申请号：US15568813

申请日：2016-04-25

申请人： International Flavor & Fragrances Inc.

发明人： Lewis Michael Popplewell ,  Franklin Pringgosusanto ,  Lulu Henson

IPC分类号： A23L27/00 ,  A61K8/92 ,  A61K8/81 ,  B33Y70/00 ,  A61K8/25 ,  B29C64/112 ,  A61K8/02 ,  A61Q13/00 ,  A61K8/85 ,  A61Q15/00 ,  B29C64/295 ,  B29C64/209 ,  A23P20/25

摘要： Methods of preparing a delivery system are described. Each method uses a first and second printing materials. The second printing material contains an active material such as a fragrance, flavor, malodor counteracting agent, and mixture thereof.

公开(公告)号：US10953049B2

公开(公告)日：2021-03-23

申请号：US16619145

申请日：2018-06-01

申请人： KIBOW BIOTECH, INC.

发明人： Natarajan Ranganathan

IPC分类号： A61K35/741 ,  A23L33/26 ,  A23L33/135 ,  A61P13/12

摘要： Method for maintaining and improving reduced kidney function and improving quality of life in patients suffering from diseases that result in reduced renal function comprising administering RENDAYL™ in combination with standard of care treatment.

公开(公告)号：US10787439B2

公开(公告)日：2020-09-29

申请号：US15672574

申请日：2017-08-09

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D. Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： A61K31/4525 ,  C07D405/12 ,  C07D307/71 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C303/36

摘要： N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

公开(公告)号：US10744180B2

公开(公告)日：2020-08-18

申请号：US15820962

申请日：2017-11-22

申请人： Trustees of Dartmouth College

发明人： Dean R. Madden ,  Nicholas P. Gill ,  Carrie Ann Davison ,  Mark R. Spaller

IPC分类号： A61K38/00 ,  C07K14/47 ,  A61K38/08 ,  A61K38/04 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K45/06 ,  A61K31/655 ,  A61K31/15 ,  A61K38/10 ,  A61K38/16 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08

摘要： Compositions, kits and methods for preventing or treating cystic fibrosis are provided, which include the use of a peptidomimetic that inhibits the interaction between CAL and mutant CFTR proteins.

公开(公告)号：US10526380B2

公开(公告)日：2020-01-07

申请号：US15794503

申请日：2017-10-26

申请人： St. Jude Children's Research Hospital

发明人： Joseph Paul Taylor ,  Peipei Zhang

IPC分类号： C12N15/82 ,  C07K14/415 ,  C12N9/14 ,  C12N13/00

摘要： A nucleic acid molecule encoding a fusion protein composed of a plant cryptochrome at the amino terminus, and a GTPase-Activating Protein SH3 Domain-Binding Protein (G3BP) is provided for light-dependent, G3BP-mediated stress granule formation.

公开(公告)号：US10435345B2

公开(公告)日：2019-10-08

申请号：US15624749

申请日：2017-06-16

申请人： INTERNATIONAL FLAVORS & FRAGRANCES INC.

发明人： Sunitha Rao Tadepalli ,  Geatesh Karunakaran Tampy ,  Anubhav P. S. Narula

IPC分类号： C07C5/10 ,  C07C45/66 ,  C07C5/333 ,  C07C5/367 ,  C07D307/79 ,  C07B35/04 ,  C07C5/48 ,  C07C67/317 ,  C07C45/65

摘要： Methods of preparing unsaturated compounds or analogs through dehydrogenation of corresponding saturated compounds and/or hydrogenation of aromatic compounds are disclosed.

公开(公告)号：US10415002B2

公开(公告)日：2019-09-17

申请号：US14435395

申请日：2013-10-10

申请人： International Flavors & Fragrances Inc.

发明人： Joseph Brain ,  Robert Muir ,  Tamara Wynn Hopkins

IPC分类号： C11B9/00 ,  A61K8/11 ,  A61K8/34 ,  A61Q5/02 ,  A61Q19/10 ,  C11D3/20 ,  C11D3/50 ,  A61Q15/00 ,  A61Q17/04 ,  A61K8/84

摘要： The present invention is an ethyl vanillin and/or vanillin friable shell-core microcapsule composition prepared by combining ethyl vanillin or vanillin with preformed friable shell-core microcapsules for a time sufficient for the ethyl vanillin or vanillin and microencapsulates to interact. Wash off consumer products and a method for depositing ethyl vanillin or vanillin on a surface are also provided.

公开(公告)号：US10258571B2

公开(公告)日：2019-04-16

申请号：US12525568

申请日：2008-02-12

申请人： David Fairhurst ,  Garry Thomas Gwozdz ,  Mark Mitchnick ,  Abhijit Gokhale ,  Andrew Loxley

发明人： David Fairhurst ,  Garry Thomas Gwozdz ,  Mark Mitchnick ,  Abhijit Gokhale ,  Andrew Loxley

IPC分类号： A61K9/16 ,  A61K9/00 ,  A61L31/16

摘要： Delivery devices of a degradable or nondegradable biocompatible matrix with one or more encapsulated active pharmaceutical ingredients or one or more particle-bound active pharmaceutical ingredients dispersed in the matrix are provided. Also provided are methods for delivering an active pharmaceutical ingredient to a subject with these delivery devices. Modified vaginal rings are also provided as well as surface coatings for delivery devices which minimize bio-interaction of the coated delivery devices.

公开(公告)号：US10214563B2

公开(公告)日：2019-02-26

申请号：US15617531

申请日：2017-06-08

申请人： LANTHIOPEP B.V.

发明人： Louwe De Vries ,  Sieger Adriaan Nelemans ,  Rick Rink ,  Antonius Jacobus Marinus Roks ,  Gert Nikolaas Moll

IPC分类号： C07K7/64 ,  A61K38/12 ,  A61K45/06 ,  C07K7/06 ,  A61K38/00

摘要： The invention relates to novel pharmaceutically-useful peptides, in particular cyclic peptides that are agonists of the AngII type 2 receptor (AT2 receptor). The invention further relates to the use of such peptides as medicaments, to pharmaceutical compositions containing them, and to their production.

公开(公告)号：US10165785B2

公开(公告)日：2019-01-01

申请号：US15406951

申请日：2017-01-16

申请人： MYOS RENS Technology Inc.

发明人： Waldemar Buxmann ,  Volker Heinz ,  Stefan Toepfl

IPC分类号： A23B5/015 ,  A23B5/03 ,  A23B5/00 ,  A23L3/015 ,  A23L5/30 ,  A23L15/00 ,  A23L3/32 ,  A61K35/57 ,  A23P10/30 ,  A61K38/17 ,  C07K14/47 ,  A23D9/013 ,  A23P10/40 ,  A23L33/17

摘要： A process for producing a composition from a biological source, which composition is preserved and, especially pathogen free and is storage stable, preferably at room temperature. Embodiments of the invention provide a process for producing a composition from eggs.