公开(公告)号：US20190352273A1

公开(公告)日：2019-11-21

申请号：US16412212

申请日：2019-05-14

Applicant: Abide Therapeutics, Inc.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D295/185 ,  C07D305/08 ,  C07D263/32 ,  C07D241/12 ,  C07D213/55

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20190282568A1

公开(公告)日：2019-09-19

申请号：US16431632

申请日：2019-06-04

Applicant: Abide Therapeutics, Inc.

Inventor： Cheryl A. Grice ,  Justin S. Cisar ,  Katharine K. Duncan ,  Yu Feng ,  John J.M. Wiener ,  Olivia D. Weber

IPC: A61K31/496 ,  A61K31/506 ,  A61P25/04

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.

公开(公告)号：US10323038B2

公开(公告)日：2019-06-18

申请号：US15777201

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. Grice ,  Todd K. Jones ,  Katharine K. Duncan ,  Justin S. Cisar ,  Jeffrey E. Merit ,  Olivia D. Weber

IPC: C07D487/10 ,  C07D487/04 ,  C07D471/10 ,  C07D519/00 ,  C07D403/06 ,  C07D491/08 ,  C07D231/40 ,  C07D231/38 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12 ,  C07D413/12 ,  C07D498/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US20180282288A1

公开(公告)日：2018-10-04

申请号：US15764231

申请日：2016-09-29

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Micah NIPHAKIS ,  Todd K. JONES

IPC: C07D233/80

CPC classification number: C07D233/80 ,  C07D233/86

Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions of said inhibitors, and methods of their use for the treatment of disease.

公开(公告)号：US10030020B2

公开(公告)日：2018-07-24

申请号：US15593239

申请日：2017-05-11

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D471/10 ,  C07D519/00

Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US09994537B2

公开(公告)日：2018-06-12

申请号：US15672165

申请日：2017-08-08

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Olivia D. Weber ,  Dong-Hui Wang

IPC: C07D295/205 ,  C07D207/08 ,  C07D471/10 ,  C07D417/04 ,  C07D403/04 ,  C07D401/04 ,  C07D295/26 ,  C07D265/30 ,  C07D207/12 ,  C07D211/38 ,  C07D211/58 ,  C07D207/14 ,  C07D211/14 ,  C07D498/08 ,  C07D211/62 ,  C07D487/04 ,  C07D207/16

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US09981930B1

公开(公告)日：2018-05-29

申请号：US15814318

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. Grice ,  Donald L. Hertzog ,  Daniel J. Buzard ,  Nicole S. White

IPC: C07D295/205 ,  C07B59/00

CPC classification number: C07D295/205 ,  C07B59/002 ,  C07B2200/05

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180134675A1

公开(公告)日：2018-05-17

申请号：US15814318

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Donald L. HERTZOG ,  Daniel J. BUZARD ,  Nicole S. WHITE

IPC: C07D295/205 ,  C07B59/00

CPC classification number: C07D295/205 ,  C07B59/002 ,  C07B2200/05

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20160272602A1

公开(公告)日：2016-09-22

申请号：US15072229

申请日：2016-03-16

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Olivia D. WEBER ,  Dong-Hui WANG

IPC: C07D295/205 ,  C07D207/08 ,  C07D295/26 ,  C07D211/38 ,  C07D211/58 ,  C07D207/14 ,  C07D211/14 ,  C07D498/08 ,  C07D211/62 ,  C07D403/04 ,  C07D401/04 ,  C07D417/04 ,  C07D487/04 ,  C07D471/10 ,  C07D265/30 ,  C07D207/16 ,  C07D207/12

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

Abstract translation: 本文提供了哌嗪氨基甲酸酯和包含所述化合物的药物组合物。 主题化合物和组合物可用作MAGL和/或ABHD6的调节剂。 此外，本发明化合物和组合物可用于治疗疼痛。

公开(公告)号：US20160137649A1

公开(公告)日：2016-05-19

申请号：US14902324

申请日：2014-07-01

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Todd K. JONES ,  Justin S. CISAR ,  Cheryl A. GRICE ,  Dong-Hui WANG ,  Olivia D. WEBER

IPC: C07D487/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.

Abstract translation: 本发明提供了吡咯并吡咯氨基甲酸酯和相关的有机化合物，含有这些化合物的组合物，医疗试剂盒和使用这些化合物和组合物治疗医学病症的方法，例如实体瘤，肥胖症，唐氏综合症，阿尔茨海默病或疼痛， 在病人身上 八氢吡咯并吡咯氨基甲酸酯可以衍生自六氟异丙醇，N，N-二琥珀酰亚胺等。 还描述了在MAGL，FAAH和ABHD6测定中氨基甲酸酯的活性。