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公开(公告)号：US20180327410A1
公开(公告)日：2018-11-15
申请号：US15777199
申请日：2016-11-18
发明人： Cheryl A. GRICE , Todd K. JONES , Katherine K. DUNCAN , Olivia D. WEBER , Justin S. CISAR , Jeffrey E. MERIT
IPC分类号： C07D487/04 , C07D487/10 , C07D403/06 , C07D519/00 , C07D401/14 , C07D403/14 , C07D417/14
CPC分类号： C07D487/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/14 , C07D487/10 , C07D519/00
摘要： Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US20170327500A1
公开(公告)日：2017-11-16
申请号：US15593239
申请日：2017-05-11
发明人： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Olivia D. WEBER , Daniel J. BUZARD , Michael B. SHAGHAFI
IPC分类号： C07D471/10 , C07D519/00
CPC分类号： C07D471/10 , C07D519/00
摘要： Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US20180327416A1
公开(公告)日：2018-11-15
申请号：US15777201
申请日：2016-11-18
发明人： Cheryl A. GRICE , Todd K. JONES , Katharine K. DUNCAN , Justin S. CISAR , Jeffrey E. MERIT , Olivia D. WEBER
IPC分类号： C07D487/10 , C07D487/04 , C07D471/10 , C07D519/00 , C07D403/06 , C07D491/08 , C07D231/40 , C07D231/38 , C07D403/12 , C07D417/12 , C07D401/12 , C07D413/12
CPC分类号： C07D487/10 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/10 , C07D487/04 , C07D491/08 , C07D498/08 , C07D519/00
摘要： Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US20170334874A1
公开(公告)日：2017-11-23
申请号：US15672165
申请日：2017-08-08
IPC分类号： C07D295/205 , C07D207/08 , C07D471/10 , C07D417/04 , C07D403/04 , C07D401/04 , C07D295/26 , C07D265/30 , C07D211/62 , C07D211/58 , C07D211/38 , C07D211/14 , C07D207/16 , C07D207/14 , C07D207/12 , C07D487/04 , C07D498/08
CPC分类号： C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
摘要： Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US20180282288A1
公开(公告)日：2018-10-04
申请号：US15764231
申请日：2016-09-29
发明人： Cheryl A. GRICE , Micah NIPHAKIS , Todd K. JONES
IPC分类号： C07D233/80
CPC分类号： C07D233/80 , C07D233/86
摘要： Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions of said inhibitors, and methods of their use for the treatment of disease.
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公开(公告)号：US20160272602A1
公开(公告)日：2016-09-22
申请号：US15072229
申请日：2016-03-16
IPC分类号： C07D295/205 , C07D207/08 , C07D295/26 , C07D211/38 , C07D211/58 , C07D207/14 , C07D211/14 , C07D498/08 , C07D211/62 , C07D403/04 , C07D401/04 , C07D417/04 , C07D487/04 , C07D471/10 , C07D265/30 , C07D207/16 , C07D207/12
CPC分类号： C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
摘要： Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
摘要翻译： 本文提供了哌嗪氨基甲酸酯和包含所述化合物的药物组合物。 主题化合物和组合物可用作MAGL和/或ABHD6的调节剂。 此外，本发明化合物和组合物可用于治疗疼痛。
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7.发明申请PYRROLO-PYRROLE CARBAMATE AND RELATED ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF 有权吡咯并吡咯烷酸及其相关有机化合物，药物组合物及其医疗用途公开(公告)号：US20160137649A1
公开(公告)日：2016-05-19
申请号：US14902324
申请日：2014-07-01
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
摘要翻译： 本发明提供了吡咯并吡咯氨基甲酸酯和相关的有机化合物，含有这些化合物的组合物，医疗试剂盒和使用这些化合物和组合物治疗医学病症的方法，例如实体瘤，肥胖症，唐氏综合症，阿尔茨海默病或疼痛， 在病人身上 八氢吡咯并吡咯氨基甲酸酯可以衍生自六氟异丙醇，N，N-二琥珀酰亚胺等。 还描述了在MAGL，FAAH和ABHD6测定中氨基甲酸酯的活性。
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公开(公告)号：US20190256494A1
公开(公告)日：2019-08-22
申请号：US15777198
申请日：2016-11-18
IPC分类号： C07D401/14 , A61P25/04 , C07D487/10 , C07D413/14 , C07D491/08
摘要： Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US20180208568A1
公开(公告)日：2018-07-26
申请号：US15925517
申请日：2018-03-19
发明人： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC分类号： C07D295/205 , C07D491/107 , C07C271/10 , C07D471/10 , C07D471/04 , C07D413/10 , C07D413/06 , C07D407/06 , C07D405/14 , C07D403/10 , C07D401/10 , C07D401/04 , C07D317/58 , C07D317/46 , C07D307/79 , C07D295/26 , C07D271/06 , C07D263/32 , C07D261/08 , C07D241/04 , C07D231/56 , C07D231/16 , C07D231/12 , C07D215/46 , C07D215/42 , C07D213/55 , C07D213/40 , C07D213/38 , C07D207/14 , C07D207/09 , C07D205/04 , C07C271/12 , C07D487/04
CPC分类号： C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
摘要： This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US20180099951A1
公开(公告)日：2018-04-12
申请号：US15573272
申请日：2016-05-10
发明人： Jacqueline Lorayne BLANKMAN , Jason Robert CLAPPER , R. Alan B. EZEKOWITZ , Iain Peter FRASER , Cheryl A. GRICE , Todd K. JONES , Gary Paul O'NEILL , Archie Wayne THURSTON, Jr. , Channing Rodney BEALS
IPC分类号： C07D403/10 , A61P29/00
CPC分类号： C07D403/10 , A61K31/495 , A61P29/00 , C07D295/205
摘要： Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
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