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273 条记录 (耗时 0.027 秒)

    Phacoemulsification hook tip
    22.
    发明授权
    Phacoemulsification hook tip 有权
    晶状体乳化钩尖

    公开(公告)号：US09233021B2

    公开(公告)日：2016-01-12

    申请号：US14062254

    申请日：2013-10-24

    申请人： Alcon Research, Ltd.

    发明人： Alexander N. Artsyukhovich ,  Mikhail Boukhny ,  James Y. Chon ,  Ramon Carsola Dimalanta, Jr.

    IPC分类号： A61F9/007 ,  A61B17/32

    CPC分类号： A61F9/00745 ,  A61B17/320068

    摘要： In various embodiments, a phacoemulsification cutting tip with a straight shaft and an angled portion off of the straight shaft may include a hook on the angled portion to move an axis of rotation of the cutting tip closer to alignment with an extended centerline of the shaft. The cutting tip may be configured to torsionally rotate back and forth on an axis perpendicular to a centerline of the shaft (e.g., rotation around a y-axis). In some embodiments, lateral vibrations (e.g., side to side along an x-axis or z-axis perpendicular to the y-axis) that result from torsional rotation around the y-axis in a cutting tip without the hook may be reduced through use of the hook to balance the otherwise eccentrically weighted hook.

    摘要翻译： 在各种实施例中，具有直轴和离开直轴的成角度部分的超声乳化切割尖端可以包括在成角度部分上的钩，以使切割尖端的旋转轴线更靠近与轴的延伸中心线对准。 切割尖端可以构造成在垂直于轴的中心线的轴线（例如，围绕y轴的旋转）上来回扭转。 在一些实施例中，可以通过使用减少在没有钩的切割尖端中围绕y轴的扭转旋转引起的横向振动（例如，沿着垂直于y轴的x轴或z轴的一侧到另一侧） 的钩子来平衡否则偏心加权的钩子。

    MEMS check valve chip and methods
    23.
    发明授权
    MEMS check valve chip and methods 有权
    MEMS止回阀芯片及方法

    公开(公告)号：US09226851B2

    公开(公告)日：2016-01-05

    申请号：US13975307

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Nicholas Max Gunn

    IPC分类号： A61M5/00 ,  A61F9/007 ,  A61B3/16

    CPC分类号： A61F9/00781 ,  A61B3/16

    摘要： A MEMS check valve chip is described. The chip comprises a first side and an opposing second side, an outlet port extending from the first side to the second side, and a flexible outlet membrane anchored to the first side to overlie the outlet port. The flexible outlet membrane includes an outlet aperture and a sealing portion, and the sealing portion is movable between a closed position inhibiting fluid flow through the outlet aperture and an open position wherein the sealing portion displaces into the outlet port to permit fluid flow through the outlet aperture.

    摘要翻译： 描述了一种MEMS止回阀芯片。 芯片包括第一侧和相对的第二侧，从第一侧延伸到第二侧的出口端口以及锚固到第一侧以覆盖出口的柔性出口膜。 柔性出口膜包括出口孔和密封部分，并且密封部分可在禁止流过出口孔的流体的关闭位置和打开位置之间移动，其中密封部分移动到出口端口中，以允许流体流过出口 光圈。

    Debris Clearance System for an Ocular Implant
    25.
    发明申请
    Debris Clearance System for an Ocular Implant 有权
    眼植入物碎片清除系统

    公开(公告)号：US20150257930A1

    公开(公告)日：2015-09-17

    申请号：US14208201

    申请日：2014-03-13

    申请人： Alcon Research, Ltd.

    发明人： Casey Lind

    IPC分类号： A61F9/007

    CPC分类号： A61F9/00781

    摘要： An IOP control system for treatment of an ocular condition includes a drainage device sized for implantation into the eye of the patient, the drainage device including a fluid flow pathway to allow the flow of fluid from an inlet port to an outlet port. The drainage device also includes a flow system disposed within the drainage device and including a displaceable portion forming a part of the fluid flow pathway, the displaceable portion being displaceable via a magnetic field. An actuation system may be physically separate from the drainage device and may be configured to cooperate with the displaceable portion to displace the displaceable portion via the magnetic field to set free buildup or debris in the flow pathway.

    摘要翻译： 用于治疗眼部病症的IOP控制系统包括尺寸适于植入患者眼睛的排水装置，该排液装置包括允许流体从入口流到出口的流体流动路径。 排水装置还包括设置在排水装置内的流动系统，并且包括形成流体流动路径的一部分的可移位部分，该可移位部分可通过磁场移位。 致动系统可以与排水装置物理分离，并且可以被配置成与可移动部分配合，以通过磁场移动可移位部分，以在流动路径中设定自由积聚或碎屑。

    COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS
    26.
    发明申请
    COMPOSITIONS FOR TREATING MICROBIAL INFECTIONS 审中-公开
    用于治疗微生物感染的组合物

    公开(公告)号：US20150174137A1

    公开(公告)日：2015-06-25

    申请号：US14632547

    申请日：2015-02-26

    申请人： ALCON RESEARCH, LTD.

    发明人： Malay Ghosh ,  Masood A. Chowhan

    IPC分类号： A61K31/5383 ,  A61K47/02 ,  A61K45/06

    CPC分类号： A61K31/5383 ,  A61K9/0048 ,  A61K33/06 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to methods for treating a microbial infection comprising treating the infected tissue with a composition comprising a quinolone such as finafloxacin and a divalent cation such as magnesium. The present invention also relates to antimicrobial compositions comprising a quinolone such as finafloxacin and a divalent cation such as magnesium.

    摘要翻译： 本发明涉及用于治疗微生物感染的方法，包括用包含喹诺酮如氟尼沙星和二价阳离子如镁的组合物处理感染组织。 本发明还涉及包含喹诺酮如氟咪沙星和二价阳离子如镁的抗微生物组合物。

    SYSTEMS AND METHODS FOR PRIMING AN INTRAOCULAR PRESSURE SENSOR CHAMBER
    29.
    发明申请
    SYSTEMS AND METHODS FOR PRIMING AN INTRAOCULAR PRESSURE SENSOR CHAMBER 审中-公开
    用于引导室内压力传感器室的系统和方法

    公开(公告)号：US20150057523A1

    公开(公告)日：2015-02-26

    申请号：US13972608

    申请日：2013-08-21

    申请人： Alcon Research, Ltd.

    发明人： Nicholas Max Gunn

    IPC分类号： A61B3/16 ,  H01R43/00

    CPC分类号： A61B3/16 ,  A61B5/6867 ,  A61F9/00781 ,  Y10T29/49169

    摘要： An intraocular pressure monitoring and sensing device for implantation in an eye of a patient may include a substrate having a pressure sensor disposed on a top surface thereof and a pressure sensor cap disposed on the substrate over the pressure sensor. The pressure sensor cap may include a wall structure extending from the top surface of the substrate, the wall structure laterally surrounding the pressure sensor. The pressure sensor cap may further include a cap top situated above the pressure sensor, the cap top and wall structure together forming an interior chamber, and a chamber inlet providing fluid access to the interior chamber. At least one of the cap top and the wall structure includes a semi-permeable surface to aid in priming.

    摘要翻译： 用于植入患者眼睛的眼内压监测和感测装置可以包括具有设置在其顶表面上的压力传感器的基板和设置在压力传感器上的基板上的压力传感器盖。 压力传感器盖可以包括从基板的顶表面延伸的壁结构，壁结构横向围绕压力传感器。 压力传感器盖还可以包括位于压力传感器上方的帽顶部，帽顶部和壁部结构一起形成内部腔室，并且腔室入口提供流体进入内部腔室。 顶盖和墙壁结构中的至少一个包括半渗透表面以辅助起泡。

    RNAi-RELATED INHIBITION OF TNF alpha SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA
    30.
    发明申请
    RNAi-RELATED INHIBITION OF TNF alpha SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA 审中-公开
    肿瘤坏死因子α信号通路治疗玻璃体的RNAi相关抑制

    公开(公告)号：US20150057336A1

    公开(公告)日：2015-02-26

    申请号：US14484972

    申请日：2014-09-12

    申请人： Alcon Research, Ltd.

    发明人： Jon E. Chatterton ,  Abbot F. Clark ,  David P. Bingaman ,  Martin B. Wax ,  Adrian M. Timmers

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1138 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/53 ,  C12N2310/531

    摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions associated with elevated intraocular pressure (TOP), including glaucoma and ocular hypertension.

    摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFα）。 特别是使TNFα靶标沉默可用于治疗患有TNFα相关病症或出现TNFα相关病症风险的患者，如与眼内压升高（TOP）相关的眼部疾病，包括青光眼和高眼压症。