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公开(公告)号:US20250120582A1
公开(公告)日:2025-04-17
申请号:US18730460
申请日:2023-01-23
Inventor: Jenna Montague , Jennifer Barton , Hasina Shir
Abstract: Methods, devices and systems are described that enable identification of cancerous or pre-cancerous colon tissue. The described methods and systems rely on non-imaging. randomly sampled second harmonic generation (SHG) intensity measurements that are sufficient for differentiating between tumor and normal tissue. The disclosed methods and system further provide for angle-resolved SHG measurements associated with forward and backward scattered light that eliminate the need to obtain paired normal and cancer-suspicious measurements in each patient using the described techniques.
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公开(公告)号:US20250102360A1
公开(公告)日:2025-03-27
申请号:US18896776
申请日:2024-09-25
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ZANDEF DEKSIT INC. , DESERT BOTANICAL GARDENS
Inventor: Jnaneshwar DAS , Rakshith VISHWANATHA , Cole BRAUER , Zhiang CHEN , Lakshmi ANTERVEDI , Harish ANAND , Sophia DAVIS , Darwin MICK , Luiza APARECIDO , Kshitij SRIVASTAVA , Heather THROOP , Devin KEATING , Alejandro CUEVA RODRIGUEZ , Desmond HANAN , Kevin HULTINE , Amanda CLARKE , Jason Achilles MEZILIS , Roberta MARTIN , Elizabeth TREMBATH-REICHERT , Ramón ARROWSMITH
Abstract: An environmental monitoring system with a plurality of sensor units and an imaging system. The sensor units are configured to be distributed over a monitored area and to collect spatiotemporal data. Each of the sensor units may have a temperature sensor, an air pressure sensor, a humidity sensor, a clock, and/or a Wi-Fi transceiver. The sensor units are configured to communicatively couple together to form a sensor network. The imaging system may be configured both for handheld use and for mounted use. The imaging system may have a camera and a spectrometer. The imaging system is configured to generate a real-time semantic map of the area and position the sensor units on the semantic map. The environmental monitoring system is configured to use the semantic map and the spatiotemporal data to predict a need of the monitored area and variation of the need across the monitored area.
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公开(公告)号:US20250095347A1
公开(公告)日:2025-03-20
申请号:US18293315
申请日:2022-08-24
Inventor: Roy Asim
IPC: G06V10/82 , G06V10/778
Abstract: Described herein are means for systematically generating transparent models for computer vision and image recognition utilizing deep learning non-transparent black box models. According to a particular embodiment, there is a specially configured system for generating an explainable AI model by performing operations, including: training a Convolutional Neural Network (CNN) to classify objects; training a Convolutional Neural Network (CNN) to classify objects from training data having a set of training images; training a multi-layer perceptron (MLP) to recognize both the objects and parts of the objects; generating the explainable AI model based on the training of the MLP; receiving an image having an object embedded therein, wherein the image forms no portion of the training data for the explainable AI model; executing the CNN and the explainable AI model within an image recognition system, and generating a prediction of the object in the image via the explainable AI model; recognizing parts of the object; providing the parts recognized within the object as evidence for the prediction of the object; and generating a description of why the image recognition system predicted the object in the image based on the evidence comprising the recognized parts.
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公开(公告)号:US20250093654A1
公开(公告)日:2025-03-20
申请号:US18726715
申请日:2023-01-07
Inventor: Hong HUA , Austin WILSON
Abstract: An occlusion-capable viewing device includes an imaging lens, a collimating lens, and a virtual display module, and between the imaging lens and the collimating lens, an image inverter, and a spatial light modulator. The imaging lens projects a first inverted image of a scene on to an entrance surface of the image inverter. The image inverter rotates the first inverted image to yield a first upright image. The spatial light modulator attenuates a first image-region of the first upright image to produce a modulated optical beam. The virtual display module includes a display device and a light combiner, which combines (i) the collimated optical beam and (ii) illumination emitted by the display device to yield an occluded image.
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公开(公告)号:US20250084157A1
公开(公告)日:2025-03-13
申请号:US18829906
申请日:2024-09-10
Inventor: Michael SIERKS , Huilai TIAN
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
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公开(公告)号:US20250082636A1
公开(公告)日:2025-03-13
申请号:US18956911
申请日:2024-11-22
Inventor: Amol PATWARDHAN , Frank PORRECA , Andrej ROMANOVSKY
IPC: A61K31/506 , A61K9/00 , A61K31/165 , A61K31/357 , A61K31/416 , A61K31/55 , A61M16/01 , A61P43/00
Abstract: Compositions and methods are provided for treating, ameliorating, and preventing anesthesia-induced hypothermia and/or postsurgical associated hyperalgesia in a mammalian subject comprising administering to the subject an effective amount of an ion channel TRPV1 inhibitor.
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公开(公告)号:US20250076683A1
公开(公告)日:2025-03-06
申请号:US18954376
申请日:2024-11-20
Inventor: James T. Schwiegerling
Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights. By plotting a topographical representation of the diffraction efficiencies resulting from such a surface profile, step heights may be optimized to direct a desired level of light power into the diffraction orders corresponding to near, intermediate, and distance vision, thereby optimizing the lens performance.
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公开(公告)号:US20250074803A1
公开(公告)日:2025-03-06
申请号:US18820649
申请日:2024-08-30
Applicant: Dennis Grubb , Arizona Board of Regents on behalf of Arizona State University , FREEPORT MINERALS CORPORATION
Inventor: Anca Delgado , Evelyn Miranda , Nasser Hamdan , Leonard Santisteban , Dennis Grubb
IPC: C02F3/34 , C02F3/28 , C02F101/10 , C02F101/20 , C02F103/10
Abstract: Described herein is a method of purifying contaminated fluid influent, the method comprising: providing a reactor comprising a reactor inlet, a reactor outlet, and a purification composition; circulating contaminated fluid influent through the reactor to create a slag-treated fluid; providing a biochemical reactor comprising a biochemical reactor inlet, a biochemical reactor outlet, and a purification media; and circulating the slag-treated fluid through the biochemical reactor to generate a purified fluid. Also described herein is a contaminated fluid influent purification system, comprising: a reactor having a reactor inlet, a reactor outlet, and a purification composition; a biochemical reactor having a biochemical reactor inlet, a biochemical outlet, and a purification media; a settling tank; and a mixing tank; wherein the mixing tank is fluidly connected to a contaminated fluid influent source, the reactor and the settling tank; and wherein the settling tank is fluidly connected to the mixing tank and the biochemical reactor.
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公开(公告)号:US20250073325A1
公开(公告)日:2025-03-06
申请号:US18597598
申请日:2024-03-06
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , BAYLOR COLLEGE OF MEDICINE
Inventor: Sri KRISHNA , Marshall POSNER , Andrew SIKORA , Karen ANDERSON
Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.
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公开(公告)号:US12241855B2
公开(公告)日:2025-03-04
申请号:US18335818
申请日:2023-06-15
Applicant: Board of Regents, The University of Texas System , Arizona Board of Regents on Behalf of Arizona State University , William Marsh Rice University
Inventor: Dino Villagran , Paul Westerhoff , Jonathan Josue Calvillo Solis , Michael Wong
Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%. Providing the electrochemical sensor can include providing at least one member selected from the group consisting of perfluoro-1-octanethiol (PFTO), 2,2,2-trifluoroethanethiol (TFET) or perfluorodecanethiol (PFDT) on the surface of the glassy carbon substrate.
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