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公开(公告)号：US20250120582A1
公开(公告)日：2025-04-17
申请号：US18730460
申请日：2023-01-23
Inventor： Jenna Montague , Jennifer Barton , Hasina Shir
Abstract: Methods, devices and systems are described that enable identification of cancerous or pre-cancerous colon tissue. The described methods and systems rely on non-imaging. randomly sampled second harmonic generation (SHG) intensity measurements that are sufficient for differentiating between tumor and normal tissue. The disclosed methods and system further provide for angle-resolved SHG measurements associated with forward and backward scattered light that eliminate the need to obtain paired normal and cancer-suspicious measurements in each patient using the described techniques.
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公开(公告)号：US12239287B2
公开(公告)日：2025-03-04
申请号：US17753578
申请日：2020-09-09
Inventor： Jennifer Barton , Kelli Kiekens , Gabriella Romano , Swati Chandra , Steven Santaniello , Richard Cordova , David Vega
Abstract: A falloposcope is described, and a method of screening a patient for fallopian tube and/or ovarian cancer with the falloposcope. The falloposcope can perform optical imaging, including fluorescence imaging and/or optical coherence tomography (OCT), and optionally include a channel for a sampling wire, within a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube so a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing fluorescence stimulus wavelength through an illumination fiber of the falloposcope while imaging light at fluorescence emission wavelength through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue. Then the sampling wire is used to collect cells from the suspect tissue for karyotype and other analysis.
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Patent Agency Ranking
公开(公告)号：US10939864B2
公开(公告)日：2021-03-09
申请号：US15548692
申请日：2016-02-03
Inventor： Jennifer Barton , Urs Utzinger , Tyler Tate , Maureen Keenan , John Black
Abstract: A falloposcope is described, as is a method of screening a patient for fallopian tube and/or ovarian cancer with the Falloposcope. The falloposcope has an optical imaging subsystem capable of performing optical and fluorescence imaging, and an optical coherence tomography (OCT) channel, with a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube such that a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing at least one fluorescence stimulus wavelength through an illumination fiber of the falloposcope, while imaging light at one or more fluorescence emission wavelengths through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue from the fluorescence emission images. The OCT channel is also used to examine abnormalities in in-vivo female tissue, both to determine suspect tissue and analyze suspect abnormal tissue from fluorescence observations.
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公开(公告)号：US12144642B2
公开(公告)日：2024-11-19
申请号：US17195221
申请日：2021-03-08
Inventor： Jennifer Barton , Urs Utzinger , Tyler Tate , Maureen Keenan , John Forbes Black
IPC: A61B5/00 , A61B1/005 , A61B1/012 , A61B1/05 , A61B1/06 , A61B1/07 , A61B1/303 , A61B10/02 , A61B10/04
Abstract: A falloposcope is described, and a method of screening a patient for fallopian tube and/or ovarian cancer with the falloposcope. The falloposcope can perform optical imaging, including fluorescence imaging and/or optical coherence tomography (OCT), and optionally include a channel for a sampling wire, within a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube so a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing fluorescence stimulus wavelength through an illumination fiber of the falloposcope while imaging light at fluorescence emission wavelength through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue. Then the sampling wire is used to collect cells from the suspect tissue for karyotype and other analysis.
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公开(公告)号：US20210244346A1
公开(公告)日：2021-08-12
申请号：US17195221
申请日：2021-03-08
Inventor： Jennifer Barton , Urs Utzinger , Tyler Tate , Maureen Keenan , John Forbes Black
IPC: A61B5/00 , A61B1/303 , A61B1/005 , A61B1/07 , A61B1/05 , A61B1/012 , A61B1/06 , A61B10/02 , A61B10/04
Abstract: A falloposcope is described, and a method of screening a patient for fallopian tube and/or ovarian cancer with the falloposcope. The falloposcope can perform optical imaging, including fluorescence imaging and/or optical coherence tomography (OCT), and optionally include a channel for a sampling wire, within a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube so a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing fluorescence stimulus wavelength through an illumination fiber of the falloposcope while imaging light at fluorescence emission wavelength through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue. Then the sampling wire is used to collect cells from the suspect tissue for karyotype and other analysis.
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公开(公告)号：US20220330792A1
公开(公告)日：2022-10-20
申请号：US17753578
申请日：2020-09-09
Inventor： Jennifer Barton , Kelli Kiekens , Gabriella Romano , Swati Chandra , Steven Santaniello , Richard Cordova , David Vega
Abstract: A falloposcope is described, and a method of screening a patient for fallopian tube and/or ovarian cancer with the falloposcope. The falloposcope can perform optical imaging, including fluorescence imaging and/or optical coherence tomography (OCT), and optionally include a channel for a sampling wire, within a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube so a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing fluorescence stimulus wavelength through an illumination fiber of the falloposcope while imaging light at fluorescence emission wavelength through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue. Then the sampling wire is used to collect cells from the suspect tissue for karyotype and other analysis.
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公开(公告)号：US20180014773A1
公开(公告)日：2018-01-18
申请号：US15548692
申请日：2016-02-03
Inventor： Jennifer Barton , Urs Utzinger , Tyler Tate , Maureen Keenan , John Black
CPC classification number: A61B5/4325 , A61B1/00009 , A61B1/00082 , A61B1/0051 , A61B1/0052 , A61B1/0057 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0676 , A61B1/0684 , A61B1/07 , A61B1/303 , A61B5/0035 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/6847 , A61B5/6851 , A61B5/7282
Abstract: A falloposcope is described, as is a method of screening a patient for fallopian tube and/or ovarian cancer with the Falloposcope. The falloposcope has an optical imaging subsystem capable of performing optical and fluorescence imaging, and an optical coherence tomography (OCT) channel, with a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube such that a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing at least one fluorescence stimulus wavelength through an illumination fiber of the falloposcope, while imaging light at one or more fluorescence emission wavelengths through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue from the fluorescence emission images. The OCT channel is also used to examine abnormalities in in-vivo female tissue, both to determine suspect tissue and analyze suspect abnormal tissue from fluorescence observations.
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