公开(公告)号：US07745577B2

公开(公告)日：2010-06-29

申请号：US11283474

申请日：2005-11-17

Applicant: Mark I. Greene ,  Ramachandran Murali ,  Alan Berezov

Inventor： Mark I. Greene ,  Ramachandran Murali ,  Alan Berezov

IPC: A61K38/04 ,  A61K38/00 ,  A61K51/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC classification number: C07K16/32 ,  A61K2039/505 ,  C07K2317/565

Abstract: Novel peptides and pharmaceutical compositions comprising the same are disclosed. Conjugated compositions peptides linked to detectable agents and/or cytotoxic agents. are disclosed. Method of detecting tumors that have p185 on tumor cell surfaces are disclosed. Methods of preventing transformation of a normal cell into a tumor cell in an individual at risk of developing a tumor having tumor cells which have p185 on their surfaces are disclosed. Methods of treating an individual who has cancer characterized by tumor cells that have a p185 on their cell surfaces are disclosed.

Abstract translation: 公开了包含其的新型肽和药物组合物。 与可检测的试剂和/或细胞毒性剂连接的共轭组合物肽。 被披露。 公开了检测肿瘤细胞表面上具有p185的肿瘤的方法。 公开了防止正常细胞转化成具有在其表面具有p185的肿瘤细胞的肿瘤的风险中的个体的肿瘤细胞的方法。 公开了在细胞表面处理具有p185的肿瘤细胞特征的癌症的个体的方法。

公开(公告)号：US20100120688A1

公开(公告)日：2010-05-13

申请号：US12625706

申请日：2009-11-25

Applicant: Mark I. Greene ,  Ramachandran Murali ,  Hongtao Zhang ,  Mark Richter ,  Alan Berezov ,  Qingdu Liu ,  Jinqiu Chen

Inventor： Mark I. Greene ,  Ramachandran Murali ,  Hongtao Zhang ,  Mark Richter ,  Alan Berezov ,  Qingdu Liu ,  Jinqiu Chen

IPC: A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  C07K14/00 ,  C07K7/08 ,  C07K7/06

CPC classification number: C07K14/71 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  A61K47/48238 ,  A61K47/4833 ,  A61K47/48384 ,  A61K47/48407 ,  A61K47/48507 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6835 ,  A61K51/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/7151 ,  C07K14/82

Abstract: Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.