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21.
公开(公告)号:US08586748B2
公开(公告)日:2013-11-19
申请号:US12937006
申请日:2009-04-08
申请人: Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
发明人: Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
IPC分类号: C07D401/12 , C07D401/14 , A61K31/454
CPC分类号: C07D211/16 , C07D207/34 , C07D403/12 , C07D513/04
摘要: This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R1,R2,R4。 Ar和Het如本文所定义。 本发明还涉及使用式(I)化合物治疗通过CCR10的活性介导或维持的疾病和病症的方法。
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公开(公告)号:US20120129863A1
公开(公告)日:2012-05-24
申请号:US13058624
申请日:2009-08-05
IPC分类号: A61K31/502 , C07D237/32 , C07D403/14 , C07D413/14 , C07D417/10 , C07D413/10 , C07D417/06 , C07D409/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P29/00 , A61P9/00 , A61P9/06 , A61P13/12 , C07D403/06
CPC分类号: C07D237/32 , C07D403/06
摘要: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase. Also disclosed are pharmaceutical compositions, methods of using and making the same.
摘要翻译: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。 还公开了药物组合物,使用和制备它们的方法。
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公开(公告)号:US08063094B2
公开(公告)日:2011-11-22
申请号:US12526144
申请日:2008-02-07
申请人: Asitha Abeywardane , Denise Andersen , Tina Marie Morwick , Roger John Snow , Yancey David Ward
发明人: Asitha Abeywardane , Denise Andersen , Tina Marie Morwick , Roger John Snow , Yancey David Ward
IPC分类号: A61K31/4045 , C07D209/16
CPC分类号: C07D401/14 , C07D209/42 , C07D417/12 , C07D417/14
摘要: Heterocyclic compounds which are inhibitors of Mitrogen-Activated Protein Kinase-Activated Protein Kinase-2 (MAPKAP-K2) as described, in addition to their use in the treatment of cytokine mediated diseases.
摘要翻译: 除了它们用于治疗细胞因子介导的疾病之外,所述杂环化合物是除了用于治疗细胞因子介导的疾病之外的所述的氮活化蛋白激酶活化蛋白激酶-2(MAPKAP-K2)的抑制剂。
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公开(公告)号:US20060276496A1
公开(公告)日:2006-12-07
申请号:US11276933
申请日:2006-03-17
申请人: Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
发明人: Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
IPC分类号: A61K31/4745 , A61K31/403 , C07D471/02
CPC分类号: C07D471/02
摘要: Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
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