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1.
公开(公告)号:US20110275800A1
公开(公告)日:2011-11-10
申请号:US12937006
申请日:2009-04-08
申请人: Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
发明人: Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
IPC分类号: C07D403/14 , C07D249/04 , C07D401/06 , C07D405/14 , C07D401/14
CPC分类号: C07D211/16 , C07D207/34 , C07D403/12 , C07D513/04
摘要: This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R1,R2,R4。 Ar和Het如本文所定义。 本发明还涉及使用式(I)化合物治疗通过CCR10的活性介导或维持的疾病和病症的方法。
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2.
公开(公告)号:US08586748B2
公开(公告)日:2013-11-19
申请号:US12937006
申请日:2009-04-08
申请人: Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
发明人: Asitha Abeywardane , Derek Cogan , Younggi Choi , Donghong A. Gao , Daniel R. Goldberg , Alexander Heim-Riether , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Yang Yu
IPC分类号: C07D401/12 , C07D401/14 , A61K31/454
CPC分类号: C07D211/16 , C07D207/34 , C07D403/12 , C07D513/04
摘要: This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中R1,R2,R4。 Ar和Het如本文所定义。 本发明还涉及使用式(I)化合物治疗通过CCR10的活性介导或维持的疾病和病症的方法。
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3.Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them 有权
标题翻译: CCR10的α-取代的N-磺酰基Gylcine酰胺拮抗剂,含有它们的组合物和使用它们的方法公开(公告)号:US08859814B2
公开(公告)日:2014-10-14
申请号:US12992766
申请日:2009-05-14
申请人: Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
发明人: Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
IPC分类号: C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07C241/00 , C07C241/02 , C07D211/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D217/00 , C07D209/04 , C07D231/00 , C07D277/60 , C07D277/62 , C07D211/22 , C07D403/12 , C07D217/06 , C07D295/185 , C07D513/04 , C07D487/04 , C07D211/70 , C07D401/14 , C07D209/08 , C07D211/62 , C07C311/19 , C07D211/16 , C07D409/12 , C07D413/12 , C07C311/44 , C07D407/12 , C07D401/12
CPC分类号: C07C311/19 , C07C311/44 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/62 , C07D211/70 , C07D217/06 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D513/04
摘要: Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
摘要翻译: 公开了式(I)的化合物。 其中R1,R2Ar和Cy如本文所定义,或其药学上可接受的盐。 还公开了式(I)化合物的药物组合物,制备式I化合物的方法和使用式(I)化合物治疗与CCR10活化相关的病症的方法。
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4.ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM 有权
标题翻译: ALPHA取代的N-SULFONYL GYLCINE辅助CCR10的拮抗剂,含有它们的组合物和使用它们的方法公开(公告)号:US20110275612A1
公开(公告)日:2011-11-10
申请号:US12992766
申请日:2009-05-14
申请人: Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
发明人: Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
IPC分类号: A61K31/445 , C07D217/18 , C07D401/06 , C07D403/06 , C07D513/04 , C07D405/06 , C07C311/19 , C07D413/06 , C07D487/04 , C07D417/06 , A61K31/472 , A61K31/4545 , A61K31/454 , A61K31/4525 , A61K31/18 , C07D217/24 , A61K31/55 , A61K31/553 , A61K31/5513 , A61K31/4985 , A61P17/06 , A61P17/00 , A61P19/04 , A61P11/06 , C07D211/32
CPC分类号: C07C311/19 , C07C311/44 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/62 , C07D211/70 , C07D217/06 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D513/04
摘要: Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
摘要翻译: 公开了式(I)的化合物。 其中R1,R2Ar和Cy如本文所定义,或其药学上可接受的盐。 还公开了式(I)化合物的药物组合物,制备式I化合物的方法和使用式(I)化合物治疗与CCR10活化相关的病症的方法。
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5.Substituted [1,4]diazepino[1,2-A]indoles and azepino[1,2-A]indoles as anti-cytokine inhibitors 有权
标题翻译: 取代的[1,4]二氮杂[1,2-A]吲哚和氮杂环[1,2-A]吲哚作为抗细胞因子抑制剂公开(公告)号:US07790712B2
公开(公告)日:2010-09-07
申请号:US11276935
申请日:2006-03-17
申请人: Derek Cogan , Donghong A. Gao , Daniel R. Goldberg , Craig Andrew Miller , Neil Moss , Matthew Russell Netherton , Philip Dean Ramsden , Zhaoming Xiong
发明人: Derek Cogan , Donghong A. Gao , Daniel R. Goldberg , Craig Andrew Miller , Neil Moss , Matthew Russell Netherton , Philip Dean Ramsden , Zhaoming Xiong
IPC分类号: C07D487/04 , A61K31/519 , C07D471/04 , A61K31/4985 , A61K31/5365 , A61P37/06
CPC分类号: C07D487/04 , C07D471/04
摘要: The application relates to compounds of formula Ia and analogues thereof wherein R1 to R13 and X are as defined herein. The invention also relates to the use of the compounds of formula Ia as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
摘要翻译: 本申请涉及式Ia化合物及其类似物,其中R 1至R 13和X如本文所定义。 本发明还涉及式Ia化合物作为丝裂原活化蛋白激酶活化蛋白激酶-2(MAPKAP-k2)的抑制剂的用途,以及用于预防或治疗可被治疗的疾病或病症的方法 或通过调节受试者中MAPKAP-K2的活性和包括这些MAPKAP-K2抑制剂的药物组合物和试剂盒来预防。
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6.Derivatives of 6,7-dihydro-5H-imidazo[1,2-alpha]imidazole-3-carboxylic acid amides 有权
标题翻译: 6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-羧酸酰胺的衍生物公开(公告)号:US08552205B2
公开(公告)日:2013-10-08
申请号:US12745439
申请日:2008-11-20
申请人: Antonio Jose del Moral Barbosa, Jr. , Joerg Martin Bentzien , Steven Richard Brunette , Zhidong Chen , Derek Cogan , Donghong A. Gao , Alexander Heim-Riether , Joshua Courtney Horan , Jennifer A. Kowalski , Michael David Lawlor , Rene Marc Lemieux , Weimin Liu , Bryan McKibben , Craig Andrew Miller , Neil Moss , Matt Aaron Tschantz , Zhaoming Xiong , Hui Yu , Yang Yu
发明人: Antonio Jose del Moral Barbosa, Jr. , Joerg Martin Bentzien , Steven Richard Brunette , Zhidong Chen , Derek Cogan , Donghong A. Gao , Alexander Heim-Riether , Joshua Courtney Horan , Jennifer A. Kowalski , Michael David Lawlor , Rene Marc Lemieux , Weimin Liu , Bryan McKibben , Craig Andrew Miller , Neil Moss , Matt Aaron Tschantz , Zhaoming Xiong , Hui Yu , Yang Yu
IPC分类号: A61K31/4188 , C07D403/14 , C07D403/12 , C07D401/12 , C07D401/14
CPC分类号: C07D487/04
摘要: Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译: 6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-羧酸酰胺的衍生物对CAM和白血球素蛋白的相互作用表现出良好的抑制作用,因此可用于治疗炎性疾病。
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7.DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-alpha]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES 有权
标题翻译: 6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-羧酸酰胺的衍生物公开(公告)号:US20110224188A1
公开(公告)日:2011-09-15
申请号:US12745439
申请日:2008-11-20
申请人: Antonio Jose del Moral Barbosa , Joerg Martin Benzien , Steven Richard Brunette , Zhidong Chen , Derek Cogan , Donghong A. Gao , Alexander Heim-Riether , Joshua Courtney Horan , Jennifer A. Kowalski , Michael David Lawlor , Rene Marc Lemieux , Weimin Liu , Bryan Mckibben , Craig Andrew Miller , Neil Moss , Matt Aaron Tschantz , Zhaoming Xiong , Hui Yu , Yang Yu
发明人: Antonio Jose del Moral Barbosa , Joerg Martin Benzien , Steven Richard Brunette , Zhidong Chen , Derek Cogan , Donghong A. Gao , Alexander Heim-Riether , Joshua Courtney Horan , Jennifer A. Kowalski , Michael David Lawlor , Rene Marc Lemieux , Weimin Liu , Bryan Mckibben , Craig Andrew Miller , Neil Moss , Matt Aaron Tschantz , Zhaoming Xiong , Hui Yu , Yang Yu
IPC分类号: A61K31/501 , C07D487/04 , A61K31/454 , A61K31/4188 , A61K31/429 , A61K31/4439 , A61K31/496 , A61K31/4545 , A61K31/506 , A61P29/00 , A61P11/00 , A61P19/02 , A61P9/00 , A61P11/06 , A61P25/00 , A61P17/06 , A61P3/10
CPC分类号: C07D487/04
摘要: Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.
摘要翻译: 6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-羧酸酰胺的衍生物对CAM和白细胞整合素的相互作用表现出良好的抑制作用,因此可用于治疗炎性疾病。
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8.
公开(公告)号:US08729114B2
公开(公告)日:2014-05-20
申请号:US13581829
申请日:2011-03-02
申请人: Michael J. Burke , Derek Cogan , Donghong Amy Gao , Alexander Heim-Riether , Eugene Richard Hickey , Matthew Russell Netherton , Philip Dean Ramsden , David Charles Thompson , Zhaoming Xiong
发明人: Michael J. Burke , Derek Cogan , Donghong Amy Gao , Alexander Heim-Riether , Eugene Richard Hickey , Matthew Russell Netherton , Philip Dean Ramsden , David Charles Thompson , Zhaoming Xiong
IPC分类号: A61K31/4164 , A61K31/4192 , C07D249/04 , C07D247/02 , C07D257/04
CPC分类号: C07D249/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要: Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.
摘要翻译: 披露了可用于治疗自身免疫性疾病和其他疾病的式(I)的组织蛋白酶-S可逆抑制剂化合物。 还公开了含有该组合物的药物组合物及其制备和使用方法。
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9.
公开(公告)号:US20130158018A1
公开(公告)日:2013-06-20
申请号:US13581829
申请日:2011-03-02
申请人: Michael J. Burke , Derek Cogan , Donghong Amy Gao , Alexander Heim-Riether , Eugene Richard Hickey , Matthew Russell Netherton , Philip Dean Ramsden , David Charles Thompson , Zhaoming Xiong
发明人: Michael J. Burke , Derek Cogan , Donghong Amy Gao , Alexander Heim-Riether , Eugene Richard Hickey , Matthew Russell Netherton , Philip Dean Ramsden , David Charles Thompson , Zhaoming Xiong
IPC分类号: C07D249/04 , C07D401/06 , C07D409/14 , C07D513/04 , C07D417/06 , C07D471/04 , C07D487/04 , C07D409/12 , C07D403/04
CPC分类号: C07D249/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要: Disclosed are Cathepsin-S reversible inhibitor compounds of the formula (I) which are useful in the treatment of autoimmune and other diseases. Also disclosed are pharmaceutical compositions containing the same, and methods of making and using the same.
摘要翻译: 披露了可用于治疗自身免疫性疾病和其他疾病的式(I)的组织蛋白酶-S可逆抑制剂化合物。 还公开了含有该组合物的药物组合物及其制备和使用方法。
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公开(公告)号:US07511042B2
公开(公告)日:2009-03-31
申请号:US11002022
申请日:2004-12-01
申请人: Derek Cogan , Daniel R. Goldberg , Abdelhakim Hammach , Matthew Russell Netherton , Ronald A. Aungst
发明人: Derek Cogan , Daniel R. Goldberg , Abdelhakim Hammach , Matthew Russell Netherton , Ronald A. Aungst
IPC分类号: C07D401/02 , A61K31/44
CPC分类号: C07D401/12 , C07D249/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine mediated diseases. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译: 公开了式(I)的化合物,其中Ar1,X,R3,R4,R5和R6如本文所定义。 本发明的化合物抑制细胞因子的产生,因此可用于治疗细胞因子介导的疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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