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公开(公告)号：US20060276453A1
公开(公告)日：2006-12-07
申请号：US11276935
申请日：2006-03-17
申请人： Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
发明人： Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
IPC分类号： A61K31/551 , A61K31/55 , A61K31/498 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
摘要翻译： 杂环化合物及其类似物及其作为丝裂原活化蛋白激酶活化蛋白激酶-2（MAPKAP-k2）的抑制剂的用途，以及用于预防或治疗疾病或病症的方法，所述方法可以通过调节 MAPKAP-K2在受试者中的活性以及包括这些MAPKAP-K2抑制剂的药物组合物和试剂盒。
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公开(公告)号：US20060276496A1
公开(公告)日：2006-12-07
申请号：US11276933
申请日：2006-03-17
申请人： Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
发明人： Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
IPC分类号： A61K31/4745 , A61K31/403 , C07D471/02
CPC分类号： C07D471/02
摘要： Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
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公开(公告)号：US07470692B2
公开(公告)日：2008-12-30
申请号：US11209234
申请日：2005-08-23
申请人： Donghong Amy Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
发明人： Donghong Amy Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
IPC分类号： C07D403/12 , C07D403/14 , A61K31/501
CPC分类号： C07D487/04 , C07D209/10 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/08
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20060046986A1
公开(公告)日：2006-03-02
申请号：US11209234
申请日：2005-08-23
申请人： Donghong Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
发明人： Donghong Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/52 , A61K31/519 , A61K31/501 , A61K31/496 , A61K31/4439
CPC分类号： C07D487/04 , C07D209/10 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/08
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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公开(公告)号：US20060235017A1
公开(公告)日：2006-10-19
申请号：US11426603
申请日：2006-06-27
申请人： Pier Cirillo , Donghong Gao , Daniel Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Kamhi , Neil Moss , Matthew Netherton , Kevin Qian , Mark Ralph , Lifen Wu , Zhaoming Xiong , Ronald Aungst
发明人： Pier Cirillo , Donghong Gao , Daniel Goldberg , Abdelhakim Hammach , Ming-Hong Hao , Victor Kamhi , Neil Moss , Matthew Netherton , Kevin Qian , Mark Ralph , Lifen Wu , Zhaoming Xiong , Ronald Aungst
IPC分类号： A61K31/5377 , A61K31/513 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C07D403/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，Y，Q，W，R 3，R 4，R SUP > 5，R 6和R y在本文中定义。 本发明的化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 该化合物也可用于治疗与肿瘤学和抗凝血剂或纤维蛋白溶解疗法有关的疾病或病症。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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6.发明授权公开(公告)号：US08785489B2
公开(公告)日：2014-07-22
申请号：US13123048
申请日：2009-10-13
申请人： Asitha Abeywardane , Bennett Farmer , Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Lana Louise Smith Keenan , Ingo Andreas Mugge , Steven John Taylor , Zhaoming Xiong , Yang Yu , Qiang Zhang
发明人： Asitha Abeywardane , Bennett Farmer , Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Lana Louise Smith Keenan , Ingo Andreas Mugge , Steven John Taylor , Zhaoming Xiong , Yang Yu , Qiang Zhang
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/454 , A61K31/444 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/404 , C07D413/14 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/14 , C07D405/04 , C07D403/14 , C07D403/04 , C07D401/14 , C07D401/04 , C07D487/04 , C07D405/12 , C07D417/14 , C07D471/04 , C07D209/42
CPC分类号： A61K31/427 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
摘要翻译： 公开了本文所述的式I化合物和组合物，其是MMP-13的抑制剂。 还公开了使用和制备式I化合物的方法。
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7.发明申请公开(公告)号：US20110275631A1
公开(公告)日：2011-11-10
申请号：US13123048
申请日：2009-10-13
申请人： Asitha Abeywardane , Bennett Farmer, II , Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Lana Louise Smith Keenan , Ingo Andreas Mugge , Steven John Taylor , Zhaoming Xiong , Yang Yu , Qiang Zhang
发明人： Asitha Abeywardane , Bennett Farmer, II , Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Lana Louise Smith Keenan , Ingo Andreas Mugge , Steven John Taylor , Zhaoming Xiong , Yang Yu , Qiang Zhang
IPC分类号： A61K31/5377 , A61K31/4245 , A61K31/501 , A61K31/506 , A61K31/4439 , A61P35/04 , A61K31/444 , A61P19/02 , A61P25/00 , A61P19/10 , A61P9/10 , A61P9/00 , C07D413/14 , A61K31/454
CPC分类号： A61K31/427 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
摘要翻译： 公开了本文所述的式I化合物和组合物，其是MMP-13的抑制剂。 还公开了使用和制备式I化合物的方法。
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公开(公告)号：US20110039851A1
公开(公告)日：2011-02-17
申请号：US12738087
申请日：2008-10-14
申请人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
发明人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
IPC分类号： A61K31/5375 , C07C233/87 , C07C233/66 , C07D257/04 , C07D307/79 , C07C255/60 , C07D213/82 , C07D401/04 , C07D213/56 , C07D277/30 , C07D239/26 , C07D249/06 , C07D213/80 , C07C237/30 , C07D265/30 , C07C323/63 , A61K31/195 , A61K31/41 , A61K31/343 , A61K31/277 , A61K31/44 , A61K31/4439 , A61K31/4402 , A61K31/426 , A61K31/505 , A61K31/4192 , A61K31/4406 , A61K31/166 , A61K31/24 , A61P17/06 , A61P17/00 , A61P11/06 , A61P37/02
CPC分类号： C07D249/06 , C07C235/60 , C07C235/62 , C07C2601/02 , C07D239/26 , C07D257/04
摘要： The invention relates to a compound of formula (I): or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其互变异构体或其药学上可接受的盐，其中R 1至R 11，W，X，Y，Z和n如本文所定义。 本发明还涉及使用式（I）化合物及其组合物来治疗患者的各种疾病和病症的方法。 本发明还涉及制备式（I）化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08299123B2
公开(公告)日：2012-10-30
申请号：US12738087
申请日：2008-10-14
申请人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
发明人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07D249/06 , C07C235/60 , C07C235/62 , C07C2601/02 , C07D239/26 , C07D257/04
摘要： The invention relates to a compound of formula (I): or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其互变异构体或其药学上可接受的盐，其中R 1至R 11，W，X，Y，Z和n如本文所定义。 本发明还涉及使用式（I）化合物及其组合物来治疗患者的各种疾病和病症的方法。 本发明还涉及制备式（I）化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20050245536A1
公开(公告)日：2005-11-03
申请号：US11119524
申请日：2005-04-29
申请人： Ming-Hong Hao , Zhaoming Xiong , Ronald Aungst , Amy Davis , Derek Cogan , Daniel Goldberg
发明人： Ming-Hong Hao , Zhaoming Xiong , Ronald Aungst , Amy Davis , Derek Cogan , Daniel Goldberg
IPC分类号： A61K31/496 , A61K31/506 , C07D401/00 , C07D401/12 , C07D401/14 , C07D43/14
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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