公开(公告)号：US20080305165A1

公开(公告)日：2008-12-11

申请号：US12181038

申请日：2008-07-28

Applicant: HYUN JUNG NOH ,  CHEONG WEON CHO ,  JEONG KU ,  TAEK RHO KIM ,  HEE CHOL KANG ,  QING RI CAO ,  EUN YOUNG YANG ,  TAE KUN AN ,  EUN KYUNG JEON ,  JAE KYOUNG KO ,  HYE SUK HONG ,  IL HWAN KIM ,  HEA RAN SUH ,  HYE JIN HAN ,  GANG SOO CHAE

Inventor： HYUN JUNG NOH ,  CHEONG WEON CHO ,  JEONG KU ,  TAEK RHO KIM ,  HEE CHOL KANG ,  QING RI CAO ,  EUN YOUNG YANG ,  TAE KUN AN ,  EUN KYUNG JEON ,  JAE KYOUNG KO ,  HYE SUK HONG ,  IL HWAN KIM ,  HEA RAN SUH ,  HYE JIN HAN ,  GANG SOO CHAE

IPC: A61K9/56 ,  A61K9/14 ,  A61K9/30 ,  A61K31/38

CPC classification number: A61K9/5084 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2081 ,  A61K9/5026 ,  A61K9/5047

Abstract: Disclosed is a multiple unit type sustained release oral formulation comprising sustained release pellets formed from granules containing an active ingredient and a water-insoluble polymer, the granules being coated with a sustained release base material; and rapid release granules containing the active ingredient, and a method for preparing the same.

Abstract translation: 公开了一种多单位型缓释口服制剂，其包含由含有活性成分和水不溶性聚合物的颗粒形成的缓释丸，所述颗粒用缓释基材包被; 和含有活性成分的快速释放颗粒及其制备方法。

公开(公告)号：US20080137810A1

公开(公告)日：2008-06-12

申请号：US11634681

申请日：2006-12-06

Applicant: Chian Q. Liu ,  Raymond P. Conley ,  Albert T. Macrander ,  Hyon Chol Kang ,  G. Brian Stephenson ,  Jorg Maser

Inventor： Chian Q. Liu ,  Raymond P. Conley ,  Albert T. Macrander ,  Hyon Chol Kang ,  G. Brian Stephenson ,  Jorg Maser

IPC: G21K1/06

CPC classification number: G21K1/062 ,  B82Y10/00 ,  G21K2201/061 ,  G21K2201/067

Abstract: A zone plate multilayer structure includes a substrate carrying a plurality of alternating layers respectively formed of tungsten silicide (WSi2) and silicon (Si). The alternating layers are sequentially deposited precisely controlling a thickness of each layer from a minimum thickness of a first deposited layer adjacent the substrate to a maximum thickness of a last deposited layer. The first minimum thickness layer has a selected thickness of less than or equal to 5 nm with the thickness of the alternating layers monotonically increasing to provide a zone plate multilayer structure having a thickness of greater than 12 μm (microns). The x-rays are diffracted in Laue transmission geometry by the specific arrangement of silicon and tungsten silicide.

Abstract translation: 区域板多层结构包括承载分别由硅化钨（WSi 2 N 2）和硅（Si）形成的多个交替层的基板。 交替层顺序沉积，从邻近衬底的第一沉积层的最小厚度到最后沉积层的最大厚度精确地控制每一层的厚度。 第一最小厚度层具有小于或等于5nm的选定厚度，交替层的厚度单调增加，以提供厚度大于12μm（微米）的区域板多层结构。 X射线通过硅和硅化钨的具体布置在Laue透射几何中衍射。

公开(公告)号：US5846737A

公开(公告)日：1998-12-08

申请号：US686858

申请日：1996-07-26

Applicant: Hee Chol Kang

Inventor： Hee Chol Kang

IPC: G01N33/533 ,  C07D311/88 ,  C07K16/00

CPC classification number: G01N33/533 ,  Y10S436/80

Abstract: The invention describes useful conjugates of sulforhodamine, wherein the conjugated substance and the fluorophore are separated by an alkanoic acid spacer that is attached to the fluorophore via a sulfonamide bond. The increased length of the covalent linkage due to the spacer results in dye-conjugates having a number of surprisingly advantageous properties relative to previous sulforhodamine-labeled conjugates, including increased fluorescence.

Abstract translation: 本发明描述了磺酰罗丹胺的有用缀合物，其中共轭物质和荧光团通过经由磺酰胺键连接到荧光团上的链烷酸间隔物分离。 由间隔物引起的共价连接的长度增加导致染料缀合物相对于先前的磺酰罗丹明标记的缀合物具有许多令人惊奇的有利性质，包括增加的荧光。

公开(公告)号：US08981100B2

公开(公告)日：2015-03-17

申请号：US12666256

申请日：2008-07-24

Applicant: Hee Chol Kang ,  Kyle Gee ,  Iain Johnson ,  Michael Janes

Inventor： Hee Chol Kang ,  Kyle Gee ,  Iain Johnson ,  Michael Janes

IPC: C07D491/16 ,  C07D491/00 ,  G01N33/52

CPC classification number: G01N33/52 ,  C07D491/06 ,  C07D491/16 ,  C07F9/5442 ,  C07K5/0215 ,  G01N33/582 ,  G01N2333/4701 ,  Y10T436/17 ,  Y10T436/182

Abstract: Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.

Abstract translation: 描述了与结合硫醇化合物的亲电子反应性基团取代的荧光喹诺酮香豆素化合物。 该化合物可用于检测活细胞中氧化应激和相关过程。

公开(公告)号：US20140107323A1

公开(公告)日：2014-04-17

申请号：US14006129

申请日：2012-03-22

Applicant: Kyle Gee ,  Aimei Chen ,  Hee Chol Kang

Inventor： Kyle Gee ,  Aimei Chen ,  Hee Chol Kang

IPC: C07C309/42 ,  C07D223/08 ,  C07K1/13 ,  C07D223/26

CPC classification number: C07D225/08 ,  C07C309/42 ,  C07C2603/36 ,  C07D223/08 ,  C07D223/26 ,  C07D225/02 ,  C07K1/13 ,  C07K16/18 ,  G01N33/532

Abstract: The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application.

Abstract translation: 本公开涉及用于将点击反应性基团与载体分子或固体支持物缀合的反应性酯试剂。 反应性酯剂具有通式IA，其中在整个申请中描述了变量R1，R2，R3，Ra和L。

公开(公告)号：US08513451B2

公开(公告)日：2013-08-20

申请号：US12602388

申请日：2008-05-30

Applicant: Hee Chol Kang

Inventor： Hee Chol Kang

IPC: C07F9/02 ,  C07D207/00 ,  C12Q1/34

CPC classification number: G01N33/542 ,  C09B23/04 ,  C09B57/10 ,  C09B69/001 ,  C12Q1/34 ,  G01N33/531 ,  G01N33/573

Abstract: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.

Abstract translation: 描述了展示荧光共振能量转移（FRET）的磷脂酶A2（PLA2）特异性酶底物的组合物，合成方法和应用。 化合物通常具有以下结构：（I）其中，在整个申请中描述了变量。 这些新型化合物提供了一种灵敏的方法，用荧光比例分析法监测各种细胞，组织和小生物体中的实时PLA2特异性酶活性。

公开(公告)号：US20100203564A1

公开(公告)日：2010-08-12

申请号：US12602388

申请日：2008-05-30

Applicant: Hee Chol Kang

Inventor： Hee Chol Kang

IPC: C12Q1/34 ,  C07F9/02 ,  C07F5/02

CPC classification number: G01N33/542 ,  C09B23/04 ,  C09B57/10 ,  C09B69/001 ,  C12Q1/34 ,  G01N33/531 ,  G01N33/573

Abstract: Compositions, methods of synthesis and applications of phospholipase A2 (PLA2) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.

Abstract translation: 描述了展示荧光共振能量转移（FRET）的磷脂酶A2（PLA2）特异性酶底物的组合物，合成方法和应用。 化合物通常具有以下结构：（I）其中，在整个申请中描述了变量。 这些新型化合物提供了一种灵敏的方法，用荧光比例分析法监测各种细胞，组织和小生物体中的实时PLA2特异性酶活性。

公开(公告)号：US20080279938A1

公开(公告)日：2008-11-13

申请号：US12181112

申请日：2008-07-28

Applicant: CHEONG WEON CHO ,  JEONG KU ,  HEE CHOL KANG ,  QING Ri CAO ,  EUN YOUNG YANG ,  TAE KUN AN ,  EUN KYUNG JEON ,  JAE KYOUNG KO ,  HEA RAN SUH ,  HYE JIN HAN ,  GANG SOO CHAE

Inventor： CHEONG WEON CHO ,  JEONG KU ,  HEE CHOL KANG ,  QING Ri CAO ,  EUN YOUNG YANG ,  TAE KUN AN ,  EUN KYUNG JEON ,  JAE KYOUNG KO ,  HEA RAN SUH ,  HYE JIN HAN ,  GANG SOO CHAE

IPC: A61K9/26 ,  A61K31/38 ,  A61P29/00

CPC classification number: A61K9/2054 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2077 ,  A61K31/38

Abstract: Disclosed is a zaltoprofen-containing sustained release tablet comprising granules containing zaltoprofen and a binder, in which the granules are dispersed in a matrix comprising a hydrophilic polymer, and a diluent is present either in the granules or in the matrix.

Abstract translation: 公开了含有扎洛芬的持续释放片剂，其包含含有扎洛芬和粘合剂的颗粒，其中颗粒分散在包含亲水性聚合物的基质中，稀释剂存在于颗粒中或基质中。

公开(公告)号：US06281331B1

公开(公告)日：2001-08-28

申请号：US09045920

申请日：1998-03-23

Applicant: Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader

Inventor： Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader

IPC: C07K706

CPC classification number: C07K14/005 ,  C12N2740/16122

Abstract: The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as “DP-178”; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

Abstract translation: 本发明首先涉及合成肽，特别是T-20（也称为“DP-178”; SEQ ID NO：1）和T-20样肽的方法。 这些方法利用固相和液相合成方法来合成和组合特定肽片段的基团以产生感兴趣的肽。 本发明还涉及在合成目标肽（例如T-20）中充当中间体的单个肽片段。 本发明还涉及可以一起用于产生全长T-20和T-20样肽的这种肽中间体片段的基团。

公开(公告)号：US5723218A

公开(公告)日：1998-03-03

申请号：US484151

申请日：1995-06-07

Applicant: Richard P. Haugland ,  Rosaria P. Haugland ,  John Michael Brinkley ,  Hee Chol Kang ,  Michael Kuhn ,  K. Sam Wells ,  Yu Zhong Zhang

Inventor： Richard P. Haugland ,  Rosaria P. Haugland ,  John Michael Brinkley ,  Hee Chol Kang ,  Michael Kuhn ,  K. Sam Wells ,  Yu Zhong Zhang

IPC: C09K11/06 ,  G01N33/533 ,  B32B27/18

CPC classification number: G01N33/533 ,  C09K11/06 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2998

Abstract: The invention is a novel fluorescently labeled microparticle, where the microparticle internally incorporates at least one dipyrrometheneboron difluoride dye. Appropriate selection of substituents results in dipyrrometheneboron difluoride derivatives that, when incorporated into polymer microparticles, give the desired excitation and emission wavelengths. The spectral characteristics of the labeling dyes in liquid are not greatly changed when the dye is incorporated into the particles, and the spectral excitation and emission wavelengths are compatible with commonly used filter sets. Other embodiments of the fluorescent microparticles include additional dyes and/or bioreactive substances.

Abstract translation: 本发明是一种新型荧光标记微粒，其中微粒内部掺入至少一种二吡咯亚甲基二氟化物染料。 取代基的适当选择导致二吡咯亚甲基二氟化物衍生物，当掺入聚合物微粒中时，得到期望的激发和发射波长。 当染料掺入颗粒中时，液体中标记染料的光谱特性没有大的变化，光谱激发和发射波长与通常使用的滤光片组兼容。 荧光微粒的其它实施方案包括另外的染料和/或生物反应性物质。