公开(公告)号：US20080066049A1

公开(公告)日：2008-03-13

申请号：US11852952

申请日：2007-09-10

Applicant: Sandeep Jain ,  David Knight

Inventor： Sandeep Jain ,  David Knight

IPC: G06F9/44

CPC classification number: G06F21/6218 ,  G06F8/70 ,  G06F8/71 ,  G06F17/50 ,  G06Q10/06

Abstract: A set of tools and other mechanisms automatically enforce software development change policies by providing a way to map physical source control system codelines to projects and by providing a way to maintain current project and codeline state information. The set of tools and other mechanisms also provide ways to define change management rules and policies, as well as, ways to evaluate and allow or deny each proposed change against the defined change policy.

Abstract translation: 一套工具和其他机制通过提供一种将物理源控制系统代码线映射到项目并通过提供一种维护当前项目和代码状态信息的方法来自动实施软件开发变更策略。 一套工具和其他机制还提供了确定变更管理规则和政策的方法，以及如何评估和允许或拒绝每项拟议的变更与定义的变更政策。

公开(公告)号：US20080034085A1

公开(公告)日：2008-02-07

申请号：US11627024

申请日：2007-01-25

Applicant: Jitendra Chawla ,  David Knight ,  Edward Wong ,  Manish Kumar ,  Shawn Farshchi ,  Eric Montoya

Inventor： Jitendra Chawla ,  David Knight ,  Edward Wong ,  Manish Kumar ,  Shawn Farshchi ,  Eric Montoya

IPC: G06F15/173

CPC classification number: H04L67/22 ,  G06Q10/103 ,  H04L12/1831 ,  H04N7/15 ,  H04N21/44218

Abstract: In one embodiment, the methods and apparatuses detect devices participating in a conference; monitor the devices for an attribute corresponding to an attention level of each of the devices; and determine whether each device is active based on the attention level.

Abstract translation: 在一个实施例中，所述方法和装置检测参与会议的设备; 监视与每个设备的关注度相对应的属性的设备; 并根据注意力水平确定每个设备是否处于活动状态。

公开(公告)号：US20070265993A1

公开(公告)日：2007-11-15

申请号：US11458244

申请日：2006-07-18

Applicant: David Knight ,  Elaine Montgomery ,  Chris Daniels ,  Linda Wu ,  Ilan Kasan

Inventor： David Knight ,  Elaine Montgomery ,  Chris Daniels ,  Linda Wu ,  Ilan Kasan

IPC: G06F17/30

CPC classification number: G06F17/30699 ,  G06F17/30867

Abstract: In one embodiment, the methods and apparatuses detect a plurality of targets; select one of the plurality of targets as a selected target; detect a profile associated with the selected target; and display information associated with the selected target, wherein the information is referenced in the profile associated with the selected target.

Abstract translation: 在一个实施例中，所述方法和装置检测多个目标; 选择多个目标之一作为选定目标; 检测与所选择的目标相关联的简档; 并显示与所选择的目标相关联的信息，其中所述信息在与所选择的目标相关联的简档中引用。

公开(公告)号：US20070160606A1

公开(公告)日：2007-07-12

申请号：US11240275

申请日：2005-09-30

Applicant: George Heavner ,  Jill Giles-Komar ,  David Knight ,  Bernard Scallon ,  David Shealy

Inventor： George Heavner ,  Jill Giles-Komar ,  David Knight ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  A61K38/19 ,  A61K38/17

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/92

Abstract: The present invention relates to at least one novel anti-TNF antibody, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices, including the treatment of renal cell carcinoma.

Abstract translation: 本发明涉及至少一种新的抗TNF抗体，包括编码至少一种抗TNF抗体，TNF，载体，宿主细胞，转基因动物或植物的分离核酸及其制备和使用方法，包括治疗 组合物，方法和装置，包括治疗肾细胞癌。

公开(公告)号：US07179893B2

公开(公告)日：2007-02-20

申请号：US11400787

申请日：2006-04-07

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: C07K16/28 ,  C12N5/12

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07179466B2

公开(公告)日：2007-02-20

申请号：US10187121

申请日：2002-06-28

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghraveb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghraveb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07169388B2

公开(公告)日：2007-01-30

申请号：US10957134

申请日：2004-09-30

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07166595B2

公开(公告)日：2007-01-23

申请号：US10429195

申请日：2003-05-02

Applicant: Han-Jie Zhou ,  David J. Morgans, Jr. ,  Gustave Bergnes ,  Steven David Knight ,  Kenneth A. Newlander ,  Dashyant Dhanak ,  Nicholas D. Adams

Inventor： Han-Jie Zhou ,  David J. Morgans, Jr. ,  Gustave Bergnes ,  Steven David Knight ,  Kenneth A. Newlander ,  Dashyant Dhanak ,  Nicholas D. Adams

IPC: C07D239/36 ,  A61K31/513 ,  A61K31/517 ,  C07D239/70

CPC classification number: C07D239/36 ,  C07D231/12 ,  C07D233/56 ,  C07D239/47 ,  C07D239/91 ,  C07D249/08 ,  C07D403/06

Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

公开(公告)号：US07166284B2

公开(公告)日：2007-01-23

申请号：US10371443

申请日：2003-02-21

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20070009524A1

公开(公告)日：2007-01-11

申请号：US10043436

申请日：2002-01-10

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07H21/04

CPC classification number: C07K16/241 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/573 ,  A61K38/00 ,  A61K39/3955 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。