-
公开(公告)号：US06854668B2
公开(公告)日：2005-02-15
申请号：US10136270
申请日：2002-04-29
申请人： Thomas Francis Wancho , David Mann
发明人： Thomas Francis Wancho , David Mann
摘要： A sprinkler discharges a column of water downwardly onto a deflector that has a plurality of peripheral tines with a respective non-radial tapered notch separating each adjacent pair of tines. Opposed cutouts with tabs in the central portion of the deflector combine with the notches and with depressed peripheral tabs to produce a predetermined spray pattern.
摘要翻译： 喷洒器将一列水向下排放到具有多个周边齿的偏转器上，该偏转器具有分开每个相邻齿尖的相应的非径向锥形切口。 在偏转器的中心部分中具有突片的相对的切口与凹口结合并且具有凹陷的周边突片以产生预定的喷射图案。
-
公开(公告)号：US06682695B2
公开(公告)日：2004-01-27
申请号：US10197248
申请日：2002-07-18
申请人： Martin MacPhee , William N. Drohan , Randall S. Kent , Tom Lynch , Glenn Calvert , Shirley Miekka , David Mann , Wilson Burgess
发明人： Martin MacPhee , William N. Drohan , Randall S. Kent , Tom Lynch , Glenn Calvert , Shirley Miekka , David Mann , Wilson Burgess
IPC分类号： A61L208
CPC分类号： A61L2/0088 , A23C3/07 , A23C3/076 , A23L3/26 , A23L3/263 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/007 , A61L2/0082 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M1/3686
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible, alone or in combination, for TSEs.
-
公开(公告)号：US06477950B1
公开(公告)日：2002-11-12
申请号：US09547554
申请日：2000-04-12
IPC分类号： B41F502
CPC分类号： B41J11/0085 , B41J3/60 , B41J11/007
摘要： The present invention is an apparatus and method for duplex printing of a sheet-like substrate in a continuous single-pass flat printing process. The device comprises a first conveyor unit in communication with a feeder and a second conveyor unit in communication with a delivery. Each conveyor unit has a printing device and a drying/curing device disposed adjacent to the conveyor unit for applying a printed material to the substrate. A transfer device is disposed between the two conveyor units for transferring the substrate from the first conveyor unit to the second conveyor unit and turning the substrate, thereby allowing both sides of the substrate to be printed. Alternative embodiments may include any number of conveyor units and transfer units.
摘要翻译： 本发明是一种在连续单程平面印刷工艺中双面印刷片状基材的设备和方法。 该装置包括与进料器连通的第一输送机单元和与输送器连通的第二输送机单元。 每个传送单元具有印刷装置和邻近传送单元设置的干燥/固化装置，用于将印刷材料施加到基材上。 传送装置设置在两个输送单元之间，用于将基板从第一输送单元传送到第二输送单元并转动基板，从而允许印刷基板的两面。 替代实施例可以包括任何数量的传送单元和传送单元。
-
24.发明申请公开(公告)号：US20190022170A1
公开(公告)日：2019-01-24
申请号：US15502170
申请日：2015-08-04
申请人： David MANN , Erkki RUOSLAHTI , Masanobu KOMATSU , Vascular BioSciences , Sanford Burnham Prebys Medical Discovery Institute
发明人： David Mann , Erkki Ruoslahti , Masanobu Komatsu
IPC分类号： A61K38/12 , A61K38/08 , A61K47/64 , A61K31/436 , A61K31/438 , A61K31/18 , A61K31/337 , A61K31/506 , A61P13/12 , A61P31/00 , A61P11/00 , A61P1/16 , A61P35/00 , A61P9/12 , G01N33/50 , C40B50/02
摘要： Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.
-
公开(公告)号：US09788526B2
公开(公告)日：2017-10-17
申请号：US11858675
申请日：2007-09-20
申请人： Charles David Mann
发明人： Charles David Mann
IPC分类号： A01K15/02
CPC分类号： A01K15/025 , A01K15/026
摘要： Pet toys configured to accept an edible or chewable treat which can be readily replaced. The pet toys have a first portion and a second portion which releasably engage to retain the edible treat with the toy until the treat is consumed or otherwise removed from the toy by the pet. When desired, the toy can be disassembled by removing the first portion from the second portion, new treats can be added to the toy, and the two portions reassembled.
-
26.发明申请Methods for Increasing the Selective Efficacy of Gene Therapy Using CAR Peptide and Heparan-Sulfate Mediated Macropinocytosis 有权使用CAR肽和肝素 - 硫酸盐介导的巨噬细胞增多的基因疗法提高选择功效的方法公开(公告)号：US20160022759A1
公开(公告)日：2016-01-28
申请号：US14649455
申请日：2013-12-03
申请人： David MANN , Vascular BioSciences
发明人： David Mann
CPC分类号： A61K38/08 , A61K45/06 , C12Q1/34 , G01N33/6893 , G01N2333/926 , G01N2800/12 , G01N2800/321
摘要： Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.
摘要翻译： 公开了用于引发疾病选择性巨噬细胞增多症的组合物和方法。 组合物可以作为疾病活动的标志物，并且作为经历疾病重塑的组织中增强的巨噬细胞增多的触发因素，例如伤口愈合，癌症，PAH，炎症，糖尿病，克罗恩病，溃疡性结肠炎，强直性脊柱炎，子宫内膜疾病，牛皮癣 肠易激综合征，关节炎，纤维化疾病，间质性膀胱炎，自身免疫疾病，哮喘，急性肺损伤和成人呼吸窘迫综合征。 组合物还可以用作疾病选择性细胞穿透肽在患病组织的细胞和细胞外基质中的受体。
-
公开(公告)号：US20100307321A1
公开(公告)日：2010-12-09
申请号：US12791798
申请日：2010-06-01
IPC分类号： G10H1/38
CPC分类号： G10H7/00 , G06F3/0481 , G06F3/167 , G09B15/00 , G10H1/0025 , G10H1/38 , G10H2210/125 , G10H2220/101 , G10H2220/111 , G10H2230/015 , G10H2240/075
摘要： An apparatus for enhancing audio comprising a first interface and a harmonizing module is disclosed. The first interface receive a first audio segment from a first source. The harmonizing module is coupled to the first interface. The harmonizing module is configured to identify at least one musical property of the first audio segment; calculate a subset of notes that are harmonious with the first audio segment based on the at least one musical property; and select from the subset of notes to generate an audio track to be played substantially synchronously with the first audio segment. A second interface may also be provided to receive a second audio segment from a second source. In this case, the harmonizing module may be configured to generate the audio track by transforming one or more notes of the second audio segment. A method is also provided.
摘要翻译： 公开了一种用于增强音频的装置，包括第一接口和协调模块。 第一个接口从第一个源接收第一个音频段。 协调模块耦合到第一接口。 协调模块被配置为识别第一音频段的至少一个音乐属性; 基于所述至少一个音乐属性计算与所述第一音频段和谐的音符的子集; 并且从音符子集中选择以产生要与第一音频段基本同步地播放的音轨。 还可以提供第二接口以从第二源接收第二音频段。 在这种情况下，协调模块可以被配置为通过变换第二音频段的一个或多个音符来生成音轨。 还提供了一种方法。
-
28.发明申请公开(公告)号：US20090202039A1
公开(公告)日：2009-08-13
申请号：US12264106
申请日：2008-11-03
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。
-
公开(公告)号：US07441154B2
公开(公告)日：2008-10-21
申请号：US10661200
申请日：2003-09-12
IPC分类号： G06F11/00
CPC分类号： G06F11/2257 , G06F11/2294
摘要： Embodiments of the invention provide a method for determining errors and metrics in a computer network. The method includes positioning an analyzer in communication with the network, capturing a data trace of the network with the analyzer, determining a network device topology from a first processing of the data trace, building user layer protocols using a second processing of the data trace and the determined device topology, determining errors in the network device topology using protocol experts applied to the user layer protocols in conjunction with the determined device topology, and displaying at least one of the device topology and the determined errors to a user.
摘要翻译： 本发明的实施例提供了一种用于确定计算机网络中的错误和度量的方法。 该方法包括定位与网络通信的分析器，利用分析器捕获网络的数据跟踪，从数据跟踪的第一处理确定网络设备拓扑，使用数据跟踪的第二处理构建用户层协议;以及 所确定的设备拓扑，使用协议专家确定网络设备拓扑中的错误，所述协议专家结合所确定的设备拓扑来应用于所述用户层协议，并且向用户显示所述设备拓扑和所确定的错误中的至少一个。
-
公开(公告)号：US07352706B2
公开(公告)日：2008-04-01
申请号：US10661907
申请日：2003-09-12
IPC分类号： H04L12/28
摘要： Embodiments of the invention provide a scalable method for analyzing a network. The method includes generating a data trace representative of the network, determining a topology for the network from the data trace, and sequentially analyzing each frame in the data trace to determine at least one of network errors, warnings, and metrics. The analysis of each frame generally includes analyzing a first protocol layer of the frame with a first expert engine, determining if a second protocol layer is present in the frame, passing the frame to a second expert engine, and passing the frame to additional expert engines if the frame contains additional protocol layers.
摘要翻译： 本发明的实施例提供了一种用于分析网络的可扩展方法。 该方法包括生成表示网络的数据跟踪，从数据跟踪确定网络的拓扑，以及顺序分析数据跟踪中的每个帧以确定网络错误，警告和度量中的至少一个。 每个帧的分析通常包括用第一专家引擎分析帧的第一协议层，确定帧中是否存在第二协议层，将帧传递到第二专家引擎，并将帧传递到附加的专家引擎 如果帧包含其他协议层。
-
-
-
-
-
-
-
-
-
搜索结果
49 条记录 (耗时 0.034 秒)
