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1.发明申请公开(公告)号：US20090202039A1
公开(公告)日：2009-08-13
申请号：US12264106
申请日：2008-11-03
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。
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2.发明授权公开(公告)号：US07848487B2
公开(公告)日：2010-12-07
申请号：US12264106
申请日：2008-11-03
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。
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3.发明授权Methods for sterilizing biological materials by irradiation over a temperature gradient 失效通过温度梯度照射对生物材料进行灭菌的方法公开(公告)号：US06908591B2
公开(公告)日：2005-06-21
申请号：US10197249
申请日：2002-07-18
申请人： Martin MacPhee , Glenn Calvert , Tom Lynch , Randall S. Kent , David Mann , Wilson Burgess , Shirley Miekka , William N. Drohan
发明人： Martin MacPhee , Glenn Calvert , Tom Lynch , Randall S. Kent , David Mann , Wilson Burgess , Shirley Miekka , William N. Drohan
CPC分类号： A61L2/007 , A61L2/0029 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0064 , A61L2/10 , A61L2202/22
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, spores, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译： 公开了用于灭菌组织以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶原，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合地负责的霉菌，真菌，孢子，朊病毒或类似物质。 所述方法包括用照射对一个或多个组织进行消毒。
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公开(公告)号：US06682695B2
公开(公告)日：2004-01-27
申请号：US10197248
申请日：2002-07-18
申请人： Martin MacPhee , William N. Drohan , Randall S. Kent , Tom Lynch , Glenn Calvert , Shirley Miekka , David Mann , Wilson Burgess
发明人： Martin MacPhee , William N. Drohan , Randall S. Kent , Tom Lynch , Glenn Calvert , Shirley Miekka , David Mann , Wilson Burgess
IPC分类号： A61L208
CPC分类号： A61L2/0088 , A23C3/07 , A23C3/076 , A23L3/26 , A23L3/263 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/007 , A61L2/0082 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M1/3686
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible, alone or in combination, for TSEs.
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公开(公告)号：US07252799B2
公开(公告)日：2007-08-07
申请号：US09942941
申请日：2001-08-31
申请人： Shirley I. Miekka , Wilson Burgess , William N. Drohan , Martin J. Macphee , Randall S. Kent , David M. Mann , Yuri Griko
发明人： Shirley I. Miekka , Wilson Burgess , William N. Drohan , Martin J. Macphee , Randall S. Kent , David M. Mann , Yuri Griko
IPC分类号： A61K38/46 , A61K39/395
CPC分类号： A61L2/007 , A61K38/38 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/0082
摘要： Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations containing albumin, such as plasma protein fractions, with irradiation.
摘要翻译： 公开了用于灭菌含有白蛋白的制剂的方法，以降低其中的一种或多种活性生物污染物或病原体的水平，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶，纳米细菌，衣原体，立克次体），酵母 ，霉菌，朊病毒或类似物质，单独或组合，用于TSEs和/或单细胞或多细胞寄生虫。 这些方法包括用照射消毒含有白蛋白的制剂，例如血浆蛋白质级分。
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公开(公告)号：US06946098B2
公开(公告)日：2005-09-20
申请号：US09925620
申请日：2001-08-10
申请人： Shirley I. Miekka , Wilson Burgess , William N. Drohan , Yuri Griko , Martin J. MacPhee , David M. Mann
发明人： Shirley I. Miekka , Wilson Burgess , William N. Drohan , Yuri Griko , Martin J. MacPhee , David M. Mann
CPC分类号： A61L2/0029 , A23L3/263 , A61L2/0011 , A61M1/3681 , A61M1/3683 , A61M1/3686
摘要： Methods are disclosed for sterilizing biological materials to reduce the level therein of one or more biological contaminants or pathogens, such as prions, responsible for the disease states known as transmissible spongiform encephalopathies (TSEs) in mammals. These methods involve sterilizing biological materials with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少一种或多种生物污染物或病原体（诸如朊病毒）的水平的方法，所述生物污染物或病原体负责哺乳动物称为传染性海绵状脑病（TSEs）的疾病状态。 这些方法包括用辐射灭菌生物材料。
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公开(公告)号：US06783968B2
公开(公告)日：2004-08-31
申请号：US09960704
申请日：2001-09-24
IPC分类号： A01N6300
CPC分类号： C12N13/00 , C12N9/2465 , C12Y302/01022
摘要： Methods are disclosed for sterilizing preparations of glycosidases to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, prions or similar agents responsible, alone or in combination, for TSEs. These methods involve sterilizing preparations of glycosidases, such as alpha-glucosidase or alpha-galactosidase, with irradiation.
摘要翻译： 公开了消除糖苷酶制剂的方法以降低其中一种或多种活性生物污染物或病原体如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原，尿细菌，衣原体，立克次体），酵母中的水平 ，霉菌，单细胞或多细胞寄生虫，朊病毒或类似物质，单独或组合负责TSE。 这些方法包括用照射消毒糖苷酶（例如α-葡糖苷酶或α-半乳糖苷酶）的制剂。
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公开(公告)号：US20110091353A1
公开(公告)日：2011-04-21
申请号：US12959106
申请日：2010-12-02
IPC分类号： A61L2/00
CPC分类号： A61L2/0035 , A61L2/0088
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译： 公开了用于灭菌组织以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶原，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用照射对一个或多个组织进行灭菌。
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公开(公告)号：US06749851B2
公开(公告)日：2004-06-15
申请号：US09942938
申请日：2001-08-31
IPC分类号： A61K3846
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0029 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0082 , C12N13/00
摘要： Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. These methods involve sterilizing preparations of digestive enzymes, such as trypsin, &agr;-galactosidase and iduronate-2-sulfatase, with irradiation.
摘要翻译： 公开了用于对消化酶的制备物进行消毒以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素酶，纳米细菌，衣原体，立克次体）， 对TSE和/或单细胞或多细胞寄生虫单独或组合负责的酵母，霉菌，真菌，朊病毒或类似物质。 这些方法包括消化酶的消毒，如胰蛋白酶，α-半乳糖苷酶和艾杜糖醛酸-2-硫酸酯酶的照射。
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公开(公告)号：US07229959B1
公开(公告)日：2007-06-12
申请号：US08479038
申请日：1995-06-07
申请人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
发明人： William N. Drohan , Martin J. MacPhee , Hernan Nunez , Gene Liau , Wilson H. Burgess , Thomas Maciag
IPC分类号： A61K38/36
CPC分类号： C12N5/069 , A61K31/25 , A61K31/337 , A61K31/4164 , A61K31/43 , A61K31/496 , A61K31/513 , A61K33/06 , A61K38/00 , A61K38/363 , A61K38/37 , A61K38/4833 , A61K45/06 , A61K47/42 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0052 , A61L26/0066 , A61L26/0085 , A61L27/34 , A61L27/507 , A61L2300/256 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/416 , A61L2300/418 , A61L2300/602 , C07K14/501 , C07K14/503 , C12N5/0062 , C12N2533/56 , C08L89/06 , C08L89/00 , C08L5/08 , A61K2300/00
摘要： This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial compositions, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like.
摘要翻译： 本发明提供补充和未补充的组织密封剂及其生产和使用方法。 公开了补充有至少一种抗体的组织密封剂。 该组合物可进一步补充有例如一种或多种止痛剂，抗微生物组合物，抗凝剂，抗增殖剂，抗炎化合物，细胞因子，细胞毒素，药物，生长因子，干扰素，激素，脂质，脱矿质骨或骨形态发生蛋白， 软骨诱导因子，寡核苷酸聚合物，多糖，多肽，蛋白酶抑制剂，血管收缩剂或血管扩张剂，维生素，矿物质，稳定剂等。
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