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1.发明授权公开(公告)号：US07848487B2
公开(公告)日：2010-12-07
申请号：US12264106
申请日：2008-11-03
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。
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2.发明申请公开(公告)号：US20090202039A1
公开(公告)日：2009-08-13
申请号：US12264106
申请日：2008-11-03
IPC分类号： G21K5/00
CPC分类号： C07K16/26 , A61K39/39591 , A61L2/0011 , A61L2/0035 , A61L2/0082 , A61L2/10 , A61L2/16
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing biological materials containing one or more non-aqueous solvents with irradiation.
摘要翻译： 公开了用于灭菌生物材料以减少其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合负责的霉菌，真菌，朊病毒或类似物质。 所述方法包括用辐射对含有一种或多种非水溶剂的生物材料进行灭菌。
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3.发明授权Methods for sterilizing biological materials by irradiation over a temperature gradient 失效通过温度梯度照射对生物材料进行灭菌的方法公开(公告)号：US06908591B2
公开(公告)日：2005-06-21
申请号：US10197249
申请日：2002-07-18
申请人： Martin MacPhee , Glenn Calvert , Tom Lynch , Randall S. Kent , David Mann , Wilson Burgess , Shirley Miekka , William N. Drohan
发明人： Martin MacPhee , Glenn Calvert , Tom Lynch , Randall S. Kent , David Mann , Wilson Burgess , Shirley Miekka , William N. Drohan
CPC分类号： A61L2/007 , A61L2/0029 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0064 , A61L2/10 , A61L2202/22
摘要： Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, spores, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation.
摘要翻译： 公开了用于灭菌组织以降低其中的一种或多种活性生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，如支原体，脲酶原，纳米细菌，衣原体，立克次体），酵母， 对于TSE和/或单细胞或多细胞寄生虫，单独或组合地负责的霉菌，真菌，孢子，朊病毒或类似物质。 所述方法包括用照射对一个或多个组织进行消毒。
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公开(公告)号：US06682695B2
公开(公告)日：2004-01-27
申请号：US10197248
申请日：2002-07-18
申请人： Martin MacPhee , William N. Drohan , Randall S. Kent , Tom Lynch , Glenn Calvert , Shirley Miekka , David Mann , Wilson Burgess
发明人： Martin MacPhee , William N. Drohan , Randall S. Kent , Tom Lynch , Glenn Calvert , Shirley Miekka , David Mann , Wilson Burgess
IPC分类号： A61L208
CPC分类号： A61L2/0088 , A23C3/07 , A23C3/076 , A23L3/26 , A23L3/263 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0064 , A61L2/007 , A61L2/0082 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M1/3686
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible, alone or in combination, for TSEs.
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公开(公告)号：US20090214382A1
公开(公告)日：2009-08-27
申请号：US11579497
申请日：2005-05-05
申请人： Wilson Burgess , David Mann , William Drohan , Shirley Miekka
发明人： Wilson Burgess , David Mann , William Drohan , Shirley Miekka
IPC分类号： A61L2/08
CPC分类号： A01N37/42 , A61L2/0035 , A01N25/00 , A01N2300/00
摘要： Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacterial (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible. These methods involve the use of alpha-keto acids in methods of sterilizing biological materials with irradiation.
摘要翻译： 公开了用于消毒生物材料以减少其中的一种或多种生物污染物或病原体的水平的方法，例如病毒，细菌（包括细菌和细胞内细菌，例如支原体，尿素原体，纳米细菌，衣原体，立克次体），酵母，霉菌 ，真菌，单细胞或多细胞寄生虫，和/或朊病毒或相关代理人。 这些方法涉及在用辐照灭菌生物材料的方法中使用α-酮酸。
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公开(公告)号：US20050069453A1
公开(公告)日：2005-03-31
申请号：US10672068
申请日：2003-09-29
申请人： Ren-Yo Forng , David Mann , Wilson Burgess , William Drohan , Martin MacPhee , Shirley Miekka
发明人： Ren-Yo Forng , David Mann , Wilson Burgess , William Drohan , Martin MacPhee , Shirley Miekka
CPC分类号： A61L2/007 , A61L2/0011 , A61L2/0035 , A61L2/0041 , A61L2/0047 , A61L2/0052 , A61L2/0058 , A61L2/0082 , A61L2202/22 , C12N9/6456
摘要： Methods are disclosed for sterilizing preparations of urokinase to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia and rickettsias), yeasts, molds, fungi, single or multicellular parasites, and prions or similar agents responsible, alone or in combination, for TSEs. These methods involve sterilizing preparations of urokinase with irradiation.
摘要翻译： 公开了用于消灭尿激酶制剂以降低其中一种或多种活性生物污染物或病原体如病毒，细菌（包括细胞内和细胞内细菌如支原体，尿素酶，纳米细菌，衣原体和立克次体），酵母中的水平的方法 ，霉菌，单细胞或多细胞寄生虫，以及对TSE单独或组合负责的朊病毒或类似物质。 这些方法包括用辐射对尿激酶的制剂进行消毒。
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