公开(公告)号：US06262107B1

公开(公告)日：2001-07-17

申请号：US09346263

申请日：1999-07-01

Applicant: Chun Li ,  Sidney Wallace ,  Dong-Fang Yu ,  David J. Yang

Inventor： Chun Li ,  Sidney Wallace ,  Dong-Fang Yu ,  David J. Yang

IPC: A01N4302

CPC classification number: A61K31/337 ,  A61K47/547 ,  A61K47/60 ,  A61K47/645 ,  A61K51/0497 ,  A61K2121/00 ,  A61K2123/00 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606

Abstract: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.

Abstract translation: 公开了通过将紫杉醇或多西他赛与水溶性螯合剂，聚乙二醇或聚合物如聚（1-谷氨酸）或聚（1-天冬氨酸）缀合而形成的紫杉醇和多西紫杉醇的水溶性组合物。 还公开了使用组合物治疗肿瘤，自身免疫疾病如类风湿性关节炎以及用于预测肿瘤紫杉醇摄取和放射性标记的DTPA-紫杉醇肿瘤成像的方法。 其他实施方案包括用于预防再狭窄的可植入支架的涂层。

公开(公告)号：US06240872B1

公开(公告)日：2001-06-05

申请号：US09590536

申请日：2000-06-08

Applicant: Dong Fang Zhou

Inventor： Dong Fang Zhou

IPC: B63B700

CPC classification number: B63B7/06 ,  B63B2007/003

Abstract: A foldable boat includes a bottom panel, a pair of side panels foldably and sealedly affixed on two sides of the bottom panel, and a front and rear elastic panels sealedly attached at a front and rear end of the foldable boat respectively in such a manner in a folded condition, the two side panels are adapted to be folded on top of the bottom panel overlappedly, and in an unfolded condition, the two side panels are adapted to be folded to be disposed perpendicularly with respect to the bottom panel. Moreover, a front and rear supporting frames are respectively mounted between the two side panels, so as to detachably affixed on two front panel edges of the two side panels for rigidly supporting and retaining the two side panels in the unfolded condition.

Abstract translation: 可折叠船包括底板，可折叠地密封地固定在底板的两侧上的一对侧板以及分别以折叠船的前端和后端密封地附接在折叠船的前端和后端的前后弹性板， 折叠状态，两个侧板适于在底板的上面重叠地折叠，并且在展开状态下，两个侧板适于被折叠成相对于底板垂直设置。 此外，前后支撑框架分别安装在两个侧板之间，以可拆卸地固定在两个侧板的两个前面板边缘上，用于在展开状态下刚性地支撑和保持两个侧板。

公开(公告)号：US6034246A

公开(公告)日：2000-03-07

申请号：US919206

申请日：1997-08-28

Applicant: Malcolm Francis Graham Stevens ,  Dong-Fang Shi ,  Tracey Dawn Bradshaw ,  Samantha Wrigley

Inventor： Malcolm Francis Graham Stevens ,  Dong-Fang Shi ,  Tracey Dawn Bradshaw ,  Samantha Wrigley

IPC: A61K31/42 ,  A61K31/423 ,  A61K31/425 ,  A61K31/428 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07D263/56 ,  C07D263/57 ,  C07D277/66

CPC classification number: C07D263/57 ,  C07D277/66

Abstract: There are disclosed herein 2-phenylbenzazole compounds having a 3'-substituent and a 4'-NR.sup.2 R.sup.6 substituent in the phenyl group where R.sup.5 and R.sup.6 are each hydrogen or alkyl, or where the $'-NR.sup.5 R.sup.6 substituent is N-acyl (or N-benzoyl). There are also disclosed 2-phenylbenzazole compounds in the form of 4'-N sulphamate salts. Such compounds exhibit significant selective cytotoxic activity in respect of tumor cells and provide potentially useful chemotherapeutic agents for selective treatment of a range of cancers.

Abstract translation: 本文公开了苯基中具有3'-取代基和4'-NR 2 R 6取代基的2-苯基吲唑化合物，其中R 5和R 6各自为氢或烷基，或其中$'NR5R6取代基为N-酰基（或N - 苯甲酰基）。 还公开了4'-N氨基磺酸盐形式的2-苯基唑化合物。 这样的化合物在肿瘤细胞方面表现出显着的选择性细胞毒性活性，并且提供用于选择性治疗一系列癌症的潜在有用的化学治疗剂。

公开(公告)号：US09593109B2

公开(公告)日：2017-03-14

申请号：US13594598

申请日：2012-08-24

Applicant: Jiangao Song ,  Phuongly Pham ,  Jingyuan Ma ,  Aaron Robert Novack ,  Imad Nashashibi ,  David W. G. Wone ,  Dong-Fang Shi ,  Xin Chen

Inventor： Jiangao Song ,  Phuongly Pham ,  Jingyuan Ma ,  Aaron Robert Novack ,  Imad Nashashibi ,  David W. G. Wone ,  Dong-Fang Shi ,  Xin Chen

IPC: C07D307/78 ,  C07D307/79 ,  C07D471/04 ,  C07D473/04 ,  C07D498/04

CPC classification number: C07D471/04 ,  C07D473/04 ,  C07D498/04

Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.

Abstract translation: 本公开涉及作为GPR131的激动剂或其它调节活性的化合物及其在治疗各种疾病中的用途。 在具体实施方案中，化合物的结构由式I给出：其中变量如本文所述。 还描述了用于制备式I化合物的相关组合物，制剂和方法。

公开(公告)号：US08750308B2

公开(公告)日：2014-06-10

申请号：US13380001

申请日：2011-10-14

Applicant: Jian Qiang Hu ,  Hao Dong ,  Li Huang ,  Dong Fang Ji ,  Guang Xue Li ,  Qing Ren ,  Feng Shi ,  Ke Tang ,  Yang Sheng Xiao ,  Ming Hua Zhao

Inventor： Jian Qiang Hu ,  Hao Dong ,  Li Huang ,  Dong Fang Ji ,  Guang Xue Li ,  Qing Ren ,  Feng Shi ,  Ke Tang ,  Yang Sheng Xiao ,  Ming Hua Zhao

IPC: H04B3/20

CPC classification number: H04L69/16 ,  G06F9/546 ,  H04L47/19 ,  H04L47/266 ,  H04L67/10 ,  H04L67/2814 ,  H04L67/2876 ,  H04L69/163

Abstract: This disclosure provides methods and servers to transmit data packets via Transmission Control Protocol (TCP) connections. In some aspects, transmitting data packets includes receiving a data packet from a first application on a first server. The data packet is analyzed to determine a destination address associated with a second server. The data packet is transmitted based on the address associated with the second server. In some aspects, transmitting data packets includes receiving a data packet from a second application on a second server. The data packet is analyzed to determine the destination address associated with a first application on the first server. The data packet is transmitted based on the address associated with the first application. In some aspects, transmitting data packets includes a flow control mechanism to control data transmission.

Abstract translation: 本公开提供了通过传输控制协议（TCP）连接传输数据分组的方法和服务器。 在一些方面，发送数据分组包括从第一服务器上的第一应用接收数据分组。 分析数据分组以确定与第二服务器相关联的目的地地址。 基于与第二服务器相关联的地址来发送数据分组。 在一些方面，发送数据分组包括从第二服务器上的第二应用接收数据分组。 分析数据分组以确定与第一服务器上的第一应用相关联的目的地地址。 基于与第一应用相关联的地址传输数据包。 在一些方面，发送数据分组包括用于控制数据传输的流控制机制。

公开(公告)号：US08703776B2

公开(公告)日：2014-04-22

申请号：US13495878

申请日：2012-06-13

Applicant: Aaron Robert Novack ,  Dong-Fang Shi ,  Jingyuan Ma ,  Imad Nashashibi ,  Phuongly Pham ,  Jiangao Song ,  David W. G. Wone ,  Xueyan Wang ,  Jeffrey D. Johnson ,  Brian Edward Lavan ,  Charles A. McWherter ,  Xin Chen

Inventor： Aaron Robert Novack ,  Dong-Fang Shi ,  Jingyuan Ma ,  Imad Nashashibi ,  Phuongly Pham ,  Jiangao Song ,  David W. G. Wone ,  Xueyan Wang ,  Jeffrey D. Johnson ,  Brian Edward Lavan ,  Charles A. McWherter ,  Xin Chen

IPC: A61K31/4965 ,  A01N43/60

CPC classification number: C07D233/90 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.

Abstract translation: 公开了作为GPR131的激动剂或其它调节活性的化合物。 还描述了相关的组合物，制剂和使用方法。

公开(公告)号：US20130195108A1

公开(公告)日：2013-08-01

申请号：US13380001

申请日：2011-10-14

Applicant: Jian Qiang Hu ,  Hao Dong ,  Li Huang ,  Dong Fang Ji ,  Guang Xue Li ,  Qing Ren ,  Feng Shi ,  Ke Tang ,  Yang Sheng Xiao ,  Ming Hua Zhao

Inventor： Jian Qiang Hu ,  Hao Dong ,  Li Huang ,  Dong Fang Ji ,  Guang Xue Li ,  Qing Ren ,  Feng Shi ,  Ke Tang ,  Yang Sheng Xiao ,  Ming Hua Zhao

IPC: H04L29/06

CPC classification number: H04L69/16 ,  G06F9/546 ,  H04L47/19 ,  H04L47/266 ,  H04L67/10 ,  H04L67/2814 ,  H04L67/2876 ,  H04L69/163

Abstract: This disclosure provides methods and servers to transmit data packets via Transmission Control Protocol (TCP) connections. In some aspects, transmitting data packets includes receiving a data packet from a first application on a first server. The data packet is analyzed to determine a destination address associated with a second server. The data packet is transmitted based on the address associated with the second server. In some aspects, transmitting data packets includes receiving a data packet from a second application on a second server. The data packet is analyzed to determine the destination address associated with a first application on the first server. The data packet is transmitted based on the address associated with the first application. In some aspects, transmitting data packets includes a flow control mechanism to control data transmission.

Abstract translation: 本公开提供了通过传输控制协议（TCP）连接传输数据分组的方法和服务器。 在一些方面，发送数据分组包括从第一服务器上的第一应用接收数据分组。 分析数据分组以确定与第二服务器相关联的目的地地址。 基于与第二服务器相关联的地址来发送数据分组。 在一些方面，发送数据分组包括从第二服务器上的第二应用接收数据分组。 分析数据分组以确定与第一服务器上的第一应用相关联的目的地地址。 基于与第一应用相关联的地址传输数据包。 在一些方面，发送数据分组包括用于控制数据传输的流控制机制。

公开(公告)号：US20120260509A1

公开(公告)日：2012-10-18

申请号：US13444886

申请日：2012-04-12

Applicant: Dong Fang ,  Florina Winter ,  Ashok Bakul Patel ,  Rache Jane Otter ,  Matthias Richard Hien ,  Andrew Anthony Szczepanowski

Inventor： Dong Fang ,  Florina Winter ,  Ashok Bakul Patel ,  Rache Jane Otter ,  Matthias Richard Hien ,  Andrew Anthony Szczepanowski

IPC: B26B21/52 ,  B25G1/10

CPC classification number: B26B21/52 ,  Y10T16/466

Abstract: A hand held device comprising a handle, said handle comprising a grip portion and a connection portion, said connection portion rotating with respect to said grip portion about a rotational axis, said connection portion forming a docking portion suitable for receiving an optional head unit, said docking portion being positioned opposite distally away from said grip portion, wherein rotation of the connection portion relative to the grip portion generates a specific amount of dynamic torsional resistance. The handle has a set amount of stiffness and damping and/or stiffness and momentum of inertia such that the device provides a controlled return during rotation about the rotational axis so the device can contour about the surface in a desirable manner.

Abstract translation: 一种手持式装置，包括手柄，所述手柄包括握持部分和连接部分，所述连接部分围绕旋转轴线相对于所述抓握部分旋转，所述连接部分形成适于接收可选头部单元的对接部分，所述对接部分 对接部分远离所述把手部分定位成相对于所述连接部分相对于所述把手部分的旋转产生特定量的动态扭转阻力。 手柄具有一定量的刚度和阻尼和/或刚度和惯性动量，使得该装置在围绕旋转轴线旋转期间提供受控的返回，因此该装置可以以期望的方式围绕该表面轮廓。

公开(公告)号：US08183381B2

公开(公告)日：2012-05-22

申请号：US12171209

申请日：2008-07-10

Applicant: Jingyuan Ma ,  Christopher J. Rabbat ,  Jiangao Song ,  Xin Chen ,  Imad Nashashibi ,  Zuchun Zhao ,  Aaron Novack ,  Dong Fang Shi ,  Peng Cheng ,  Yan Zhu ,  Alison Murphy

Inventor： Jingyuan Ma ,  Christopher J. Rabbat ,  Jiangao Song ,  Xin Chen ,  Imad Nashashibi ,  Zuchun Zhao ,  Aaron Novack ,  Dong Fang Shi ,  Peng Cheng ,  Yan Zhu ,  Alison Murphy

IPC: C07D401/00

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.

Abstract translation: 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

公开(公告)号：US20100005669A1

公开(公告)日：2010-01-14

申请号：US12323503

申请日：2008-11-26

Applicant: Florina Winter ,  Chunfang Song ,  Dong Fang ,  RanMin Wang ,  Brian William Cataldo ,  Jing Jun Xia

Inventor： Florina Winter ,  Chunfang Song ,  Dong Fang ,  RanMin Wang ,  Brian William Cataldo ,  Jing Jun Xia

IPC: B26B21/00

CPC classification number: B26B21/521 ,  B26B21/522 ,  B26B21/528 ,  Y10T16/476 ,  Y10T29/49 ,  Y10T29/49826

Abstract: A razor handle includes an at least partially hollow elongated structure and an at least partially hollow sleeve. The elongated structure has an interior surface and an exterior surface, a first opening at a proximate end, and a second opening along a length of the elongated structure. The sleeve has an interior surface and an exterior surface with a protrusion. The protrusion is adapted to extend through the second opening to the exterior surface of the elongated structure forming a gripping member.

Abstract translation: 剃刀手柄包括至少部分中空的细长结构和至少部分中空的套筒。 细长结构具有内表面和外表面，在近端处的第一开口和沿着细长结构的长度的第二开口。 套筒具有内表面和具有突起的外表面。 该突起适于延伸通过第二开口延伸到形成夹持构件的细长结构的外表面。