公开(公告)号：US08999706B2

公开(公告)日：2015-04-07

申请号：US11911400

申请日：2006-04-12

Applicant: Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

Inventor： Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

IPC: C12N5/00 ,  C12N15/00 ,  C12N5/074 ,  C12N5/071

CPC classification number: C12N5/0607 ,  C12N5/0628 ,  C12N2500/44 ,  C12N2501/11 ,  C12N2501/115

Abstract: Isolated human multipotent adult stem cell and isolated populations of cells that include human multipotent adult stem cells are disclosed. Human hair-follicle derived multipotent adult stem cells and methods of preparing isolated populations of cells that include human multipotent adult stem cells are disclosed. Isolated human hair-follicle derived multipotent adult stem cell that can differentiate in culture into a neuronal cell, a glial cell, a melanocyte cell, a muscle cell, an osteocyte, a chondrocyte, and a lymphocyte. Isolated human hair-follicle derived multipotent adult stem cell that can grow in cell culture in spheres are disclosed. Human pancreas derived multipotent adult stem cells, human liver derived multipotent adult stem cells, human kidney derived multipotent adult stem cells, human heart derived multipotent adult stem cells, human neural derived multipotent adult stem cells and methods of preparing isolated populations of cells that include such human multipotent adult stem cells are disclosed. Method of treating an individual who has diabetes, cardiac muscle damage, muscle damage and disease, neurodegenerative disease or nerve damage or injury, bone loss, damage and/or disease, cartilage loss, damage and/or disease, hair loss and immune disorders, are disclosed.

Abstract translation: 公开了分离的人多能成体干细胞和包括人多潜能成体干细胞的分离的细胞群。 公开了人毛囊衍生的多能成体干细胞和制备包括人多潜能成体干细胞的分离的细胞群的方法。 分离的人毛囊衍生的多能成体干细胞，其可以在培养物中分化成神经元细胞，胶质细胞，黑素细胞，肌细胞，骨细胞，软骨细胞和淋巴细胞。 公开了可以在球体的细胞培养物中生长的分离的人毛囊衍生的多潜能成体干细胞。 人胰腺来源的多能成体干细胞，人肝来源的多潜能成体干细胞，人肾来源的多潜能成体干细胞，人心源性多潜能成体干细胞，人神经衍生多潜能成体干细胞以及制备分离的细胞群的方法， 公开了人多能成体干细胞。 治疗患有糖尿病，心肌损伤，肌肉损伤和疾病，神经变性疾病或神经损伤或损伤，骨丢失，损伤和/或疾病，软骨损失，损伤和/或疾病，脱发和免疫疾病的个体的方法， 被披露。

公开(公告)号：US20130140062A1

公开(公告)日：2013-06-06

申请号：US13497467

申请日：2012-01-04

Applicant: Kuang-Yao Chang ,  Lin-Dong Fang

Inventor： Kuang-Yao Chang ,  Lin-Dong Fang

IPC: H05K1/05 ,  H05K3/00

CPC classification number: H05K1/0206 ,  H05K1/05 ,  H05K2201/09072 ,  H05K2201/10106 ,  Y10T29/49155

Abstract: A manufacturing method of a circuit board structure includes steps of: providing a circuit board which comprising a metal substrate, a metal layer and a dielectric layer disposed between the metal substrate and the metal layer; forming grooves on the circuit board to expose the metal substrate, the dielectric layer and the metal layer; performing a procedure for connecting metal in the grooves so that the metal substrate and the metal layer being in contact with each other. A structure of circuit board comprises a metal substrate, a dielectric layer and a metal layer. The dielectric layer is formed on the metal substrate, and the metal layer is formed on the dielectric layer; wherein the metal substrate and the metal layer can be in contact with each other at an appropriate position by performing a metal connecting procedure.

Abstract translation: 电路板结构的制造方法包括以下步骤：提供包括金属基板，金属层和设置在金属基板和金属层之间的电介质层的电路板; 在所述电路板上形成凹槽以暴露所述金属基板，所述电介质层和所述金属层; 执行用于在槽中连接金属使得金属基板和金属层彼此接触的过程。 电路板的结构包括金属基板，电介质层和金属层。 在金属基板上形成电介质层，在电介质层上形成金属层， 其中金属基板和金属层可以通过执行金属连接程序在适当的位置彼此接触。

公开(公告)号：US08440168B2

公开(公告)日：2013-05-14

申请号：US12340338

申请日：2008-12-19

Applicant: David J. Yang ,  Chang-Sok Oh ,  Saady Kohanim ,  Dong-Fang Yu ,  Richard Mendez ,  E. Edmund Kim

Inventor： David J. Yang ,  Chang-Sok Oh ,  Saady Kohanim ,  Dong-Fang Yu ,  Richard Mendez ,  E. Edmund Kim

IPC: A61K51/04 ,  A61K49/00

CPC classification number: A61K51/0497 ,  A61K31/165 ,  C07C235/34 ,  C07F13/00 ,  C07F13/005

Abstract: Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.

Abstract translation: 公开了用于成像和化疗和放射治疗的组合物和方法。 更具体地说，本发明涉及包含与乙二胺缀合或嵌入的β-肾上腺素能受体靶向化合物的靶向物质的试剂。 本发明还涉及这种用于心血管疾病成像和治疗的药剂的应用方法以及用于制备放射性标记的治疗剂或诊断剂的试剂盒。

公开(公告)号：US20130078253A1

公开(公告)日：2013-03-28

申请号：US13436411

申请日：2012-03-30

Applicant: Dong FANG ,  Paul MOORE ,  Steve RUBEN ,  Sudeepta AGGARWAL

Inventor： Dong FANG ,  Paul MOORE ,  Steve RUBEN ,  Sudeepta AGGARWAL

IPC: A61K39/395 ,  G01N33/574 ,  C07K16/18

CPC classification number: C07K16/249 ,  A61K39/39533 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/57 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/10

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供用于评估，治疗和预防使用癌症相关靶（CAT）的疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US20130059856A1

公开(公告)日：2013-03-07

申请号：US13495878

申请日：2012-06-13

Applicant: Aaron Robert Novack ,  Dong-Fang Shi ,  Jingyuan Ma ,  Imad Nashashibi ,  Phuongly Pham ,  Jiangao Song ,  David W. G. Wone ,  Xueyan Wang ,  Jeffrey D. Johnson ,  Brian Edward Lavan ,  Charles A. McWherter ,  Xin Chen

Inventor： Aaron Robert Novack ,  Dong-Fang Shi ,  Jingyuan Ma ,  Imad Nashashibi ,  Phuongly Pham ,  Jiangao Song ,  David W. G. Wone ,  Xueyan Wang ,  Jeffrey D. Johnson ,  Brian Edward Lavan ,  Charles A. McWherter ,  Xin Chen

IPC: A61K31/4164 ,  C07D403/12 ,  A61K31/4178 ,  C07D401/12 ,  A61K31/4439 ,  A61P3/10 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/506 ,  A61K31/4985 ,  C07D233/90 ,  A61K31/454

CPC classification number: C07D233/90 ,  C07D249/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.

Abstract translation: 公开了作为GPR131的激动剂或其它调节活性的化合物。 还描述了相关的组合物，制剂和使用方法。

公开(公告)号：US20100190831A1

公开(公告)日：2010-07-29

申请号：US12641263

申请日：2009-12-17

Applicant: Dong Fang Shi ,  Jiangao Song ,  Jingyuan Ma ,  Aaron Novack ,  Phuongly Pham ,  Imad Fayek Nashashibi ,  Christopher J. Rabbat ,  Xin Chen

Inventor： Dong Fang Shi ,  Jiangao Song ,  Jingyuan Ma ,  Aaron Novack ,  Phuongly Pham ,  Imad Fayek Nashashibi ,  Christopher J. Rabbat ,  Xin Chen

IPC: A61K31/44 ,  C07D307/79 ,  A61K31/343 ,  A61P3/10 ,  C07D311/58 ,  A61K31/352 ,  C07D319/08 ,  A61K31/357 ,  C07D307/83 ,  C07D405/10 ,  A61K31/41 ,  C07D333/60 ,  A61K31/381 ,  C07D307/94 ,  C07D213/643

CPC classification number: C07D405/04 ,  C07D213/64 ,  C07D231/56 ,  C07D235/12 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/94 ,  C07D311/58 ,  C07D319/08 ,  C07D333/54 ,  C07D333/60 ,  C07D405/10 ,  C07D407/04 ,  C07D407/12

Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

Abstract translation: 提供GPR120激动剂。 这些化合物可用于治疗代谢疾病，包括II型糖尿病和与血糖控制不良相关的疾病。

公开(公告)号：US20090238756A1

公开(公告)日：2009-09-24

申请号：US12340338

申请日：2008-12-19

Applicant: David J. Yang ,  Chang-Sok Oh ,  Saady Kohanim ,  Dong-Fang Yu ,  Richard Mendez ,  E. Edmund Kim

Inventor： David J. Yang ,  Chang-Sok Oh ,  Saady Kohanim ,  Dong-Fang Yu ,  Richard Mendez ,  E. Edmund Kim

IPC: A61K51/04 ,  C07C233/40 ,  A61K49/00 ,  A61K49/22 ,  A61K31/165 ,  A61P9/00 ,  A61K49/04 ,  A61K49/10 ,  C07F13/00

CPC classification number: A61K51/0497 ,  A61K31/165 ,  C07C235/34 ,  C07F13/00 ,  C07F13/005

Abstract: Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.

Abstract translation: 公开了用于成像和化疗和放射治疗的组合物和方法。 更具体地说，本发明涉及包含与乙二胺缀合或嵌入的β-肾上腺素能受体靶向化合物的靶向物质的试剂。 本发明还涉及这种用于心血管疾病成像和治疗的药剂的应用方法以及用于制备放射性标记的治疗剂或诊断剂的试剂盒。

公开(公告)号：US20090130065A1

公开(公告)日：2009-05-21

申请号：US11911400

申请日：2006-04-12

Applicant: Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

Inventor： Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

IPC: A61K35/12 ,  C12N5/08

CPC classification number: C12N5/0607 ,  C12N5/0628 ,  C12N2500/44 ,  C12N2501/11 ,  C12N2501/115

Abstract: Isolated human multipotent adult stem cell and isolated populations of cells that include human multipotent adult stem cells are disclosed. Human hair-follicle derived multipotent adult stem cells and methods of preparing isolated populations of cells that include human multipotent adult stem cells are disclosed. Isolated human hair-follicle derived multipotent adult stem cell that can differentiate in culture into a neuronal cell, a glial cell, a melanocyte cell, a muscle cell, an osteocyte, a chondrocyte, and a lymphocyte. Isolated human hair-follicle derived multipotent adult stem cell that can grow in cell culture in spheres are disclosed. Human pancreas derived multipotent adult stem cells, human liver derived multipotent adult stem cells, human kidney derived multipotent adult stem cells, human heart derived multipotent adult stem cells, human neural derived multipotent adult stem cells and methods of preparing isolated populations of cells that include such human multipotent adult stem cells are disclosed. Method of treating an individual who has diabetes, cardiac muscle damage, muscle damage and disease, neurodegenerative disease or nerve damage or injury, bone loss, damage and/or disease, cartilage loss, damage and/or disease, hair loss and immune disorders, are disclosed.

Abstract translation: 公开了分离的人多能成体干细胞和包括人多潜能成体干细胞的分离的细胞群。 公开了人毛囊衍生的多能成体干细胞和制备包括人多潜能成体干细胞的分离的细胞群的方法。 分离的人毛囊衍生的多能成体干细胞，其可以在培养物中分化成神经元细胞，胶质细胞，黑素细胞，肌细胞，骨细胞，软骨细胞和淋巴细胞。 公开了可以在球体的细胞培养物中生长的分离的人毛囊衍生的多潜能成体干细胞。 人胰腺来源的多能成体干细胞，人肝来源的多潜能成体干细胞，人肾来源的多潜能成体干细胞，人心源性多潜能成体干细胞，人神经衍生多潜能成体干细胞以及制备分离的细胞群的方法， 公开了人多能成体干细胞。 治疗患有糖尿病，心肌损伤，肌肉损伤和疾病，神经变性疾病或神经损伤或损伤，骨丢失，损伤和/或疾病，软骨损失，损伤和/或疾病，脱发和免疫疾病的个体的方法， 被披露。

公开(公告)号：US20080300389A1

公开(公告)日：2008-12-04

申请号：US12009421

申请日：2008-01-18

Applicant: David J. Yang ,  Dong-Fang Yu ,  I-Chien Wei

Inventor： David J. Yang ,  Dong-Fang Yu ,  I-Chien Wei

IPC: C07H15/00

CPC classification number: A61K33/24 ,  A61K31/282 ,  A61K47/61

Abstract: The current disclosure, in one embodiment, includes a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid. According to another embodiment, the disclosure provides a method of synthesizing a polysaccharide conjugate by covalently bonding a monomeric amino acid having an O-group to a polysaccharide and by conjugating a metal to the O-group to form a polysaccharide conjugate. According to a third embodiment, the disclosure relates to a method of killing a cancer cell by administering to the cell an effective amount of a polysaccharide conjugate. This conjugate has a polysaccharide and at least one monomeric amino acid having an O-group covalently bound to the polysaccharide. The conjugate also has at least one metal conjugated by the O-group of the amino acid.

Abstract translation: 在一个实施方案中，本公开内容包括多糖缀合物。 该缀合物具有多糖和至少一个与多糖共价结合的具有O-基团的单体氨基酸。 缀合物还具有至少一种由氨基酸的O-基缀合的金属。 根据另一个实施方案，本公开提供了通过将具有O-基团的单体氨基酸与多糖共价键合并通过将金属与O基团缀合以形成多糖缀合物来合成多糖缀合物的方法。 根据第三实施方案，本公开涉及通过向细胞施用有效量的多糖缀合物来杀死癌细胞的方法。 该缀合物具有多糖和至少一个与多糖共价结合的具有O-基团的单体氨基酸。 缀合物还具有至少一种由氨基酸的O-基缀合的金属。

公开(公告)号：US20080123370A1

公开(公告)日：2008-05-29

申请号：US11998053

申请日：2007-11-27

Applicant: Sin-Tung Huang ,  Lin-Dong Fang

Inventor： Sin-Tung Huang ,  Lin-Dong Fang

IPC: F21V7/04

CPC classification number: G02F1/133615 ,  G02F1/133608 ,  G02F2001/133328

Abstract: An exemplary backlight module includes a tray and at least two opposite frame beams. The tray includes two opposite side walls, and the side walls include a plurality of first fixing members. The two frame beams are separate pieces from each other, and include a plurality of second fixing members secured with the first fixing members such that the two frame beams are fixed to the tray. A liquid crystal display including the backlight module is also provided.

Abstract translation: 示例性背光模块包括托盘和至少两个相对的框架梁。 托盘包括两个相对的侧壁，并且侧壁包括多个第一固定构件。 两个框架梁彼此分开，并且包括固定有第一固定构件的多个第二固定构件，使得两个框架梁固定到托盘。 还提供了包括背光模块的液晶显示器。