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    GROUP A STREPTOCOCCUS VACCINE
    21.
    发明申请
    GROUP A STREPTOCOCCUS VACCINE 审中-公开

    公开(公告)号：US20190256562A1

    公开(公告)日：2019-08-22

    申请号：US16398598

    申请日：2019-04-30

    Applicant: Griffith University

    Inventor： Manisha Pandey ,  Michael Batzloff ,  Michael Good

    IPC: C07K14/315 ,  A61K38/48 ,  A61K39/395 ,  C07K16/40 ,  A61K39/09 ,  C07K16/12

    Abstract: The invention relates to methods of eliciting an immune response to group A streptococcal bacteria in a mammal, the method including the step of administering to the mammal an effective amount of a composition comprising an isolated p145 peptide of SEQ ID NO: 56 and/or a p145 peptide variant having an amino acid sequence at least 90% identical to SEQ ID NO: 56, and an isolated SpyCEP peptide of SEQ ID NO: 18 and/or a SpyCEP peptide variant having an amino acid sequence at least 90% identical to SEQ ID NO: 18.

    VACCINE COMPRISING DRUG AND PARASITE ADMINISTRATION
    22.
    发明申请
    VACCINE COMPRISING DRUG AND PARASITE ADMINISTRATION 审中-公开

    公开(公告)号：US20190224293A1

    公开(公告)日：2019-07-25

    申请号：US16333675

    申请日：2016-10-24

    Applicant: GRIFFITH UNIVERSITY

    Inventor： Michael GOOD ,  Danielle STANISIC ,  Leanne LOW

    IPC: A61K39/018 ,  A61P33/06 ,  A61K31/65 ,  A61K31/7056 ,  A61K31/435 ,  A01K67/027

    Abstract: Apicomplexan parasites or red blood cells infected with apicomplexan parasites are administered to an animal in combination with a delayed death agent that initially allows parasite replication but subsequently kills the apicomplexan parasites. This allows the elicitation of an immune response by the animal while preventing the parasites producing a serious infection of the animal. The apicomplexan parasites may be malaria or babesia parasites. The delayed death agent may be a tetracycline class antibiotic, a macrolide antibiotic or a lincosamide antibiotic.

    VENTRICULAR ASSISTANCE SYSTEM AND METHOD
    24.
    发明申请
    VENTRICULAR ASSISTANCE SYSTEM AND METHOD 有权

    公开(公告)号：US20210379354A1

    公开(公告)日：2021-12-09

    申请号：US17288340

    申请日：2019-10-30

    Applicant: Griffith University

    Inventor： Geoff Tansley ,  Alice Catherine Boone

    IPC: A61M60/17 ,  A61M60/295 ,  A61M60/497 ,  A61M60/515 ,  A61M60/857 ,  A61M60/843

    Abstract: A system for providing ventricular assistance to a heart of a subject, the system including a balloon configured to be inserted into a ventricle of the heart, wherein the balloon is configured to differentially inflate to thereby urge blood towards a semilunar valve of the ventricle; a fluid conduit in fluid communication with the balloon; a pumping mechanism attached to the fluid conduit; and, a controller configured to control the pumping mechanism to thereby selectively supply fluid into the balloon so as to inflate the balloon at least partially in accordance with the cardiac cycle.

    METHODS FOR TREATING CHRONIC FATIGUE SYNDROME AND MYALGIC ENCEPHALOMYELITIS
    25.
    发明申请
    METHODS FOR TREATING CHRONIC FATIGUE SYNDROME AND MYALGIC ENCEPHALOMYELITIS 有权

    公开(公告)号：US20210069180A1

    公开(公告)日：2021-03-11

    申请号：US16992005

    申请日：2020-08-12

    Applicant: GRIFFITH UNIVERSITY

    Inventor： Sonya M. Marshall-Gradisnik ,  Donald R. Staines ,  Peter Kenneth Smith ,  Helene Marie Cabanas

    IPC: A61K31/485

    Abstract: In one aspect the invention relates to a method of treatment selected from the group consisting of: (a) treating a symptom such as pain in a subject identified or diagnosed as having Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); (b) treating a symptom such as pain in a subject having dysfunctional TRPM3 ion channel activity; (c) restoring NK cell function in a subject having dysfunctional TRPM3 ion channel activity; and (d) restoring calcium homeostasis in a subject having dysfunctional TRPM3 ion channel activity. The method comprises the step of administering to the subject a therapeutically effective amount of at least one therapeutic compound selected from the group consisting of: (i) an opioid receptor antagonist; (ii) an opioid antagonist; and (iii) a therapeutic compound that restores TRPM3 ion channel activity. In some embodiments the therapeutic compound is naltrexone hydrochloride.

    SILICON CARBIDE SCHOTTKY DIODES
    28.
    发明申请
    SILICON CARBIDE SCHOTTKY DIODES 审中-公开

    公开(公告)号：US20200091281A1

    公开(公告)日：2020-03-19

    申请号：US16469809

    申请日：2017-12-13

    Applicant: GRIFFITH UNIVERSITY

    Inventor： Sima DIMITRIJEV ,  Jisheng HAN

    IPC: H01L29/06 ,  H01L29/16 ,  H01L29/872 ,  H01L29/66 ,  H01L21/3065 ,  H01L21/308

    Abstract: A silicon carbide (SiC) Schottky diode comprises a layer of N-type SiC and a layer of P-type SiC in contact with the layer of N-type SiC creating a P-N junction. An anode is in contact with both the layer of N-type SiC and the layer of P-type SiC creating Schottky contacts between the anode and both the layer of N-type SiC and the layer of P-type SiC. An edge of the layer of P-type SiC is electrically active and comprises a tapered negative charge density at the P-N junction, which can be achieved by a tapered or sloping edge the layer of P-type SiC.

    TREATMENT OF ALPHAVIRUS-INDUCED INFLAMMATION
    30.
    发明申请
    TREATMENT OF ALPHAVIRUS-INDUCED INFLAMMATION 审中-公开

    公开(公告)号：US20190255097A1

    公开(公告)日：2019-08-22

    申请号：US16304550

    申请日：2016-05-26

    Applicant: GRIFFITH UNIVERSITY

    Inventor： Surendran Mahalingam ,  Lara Josefina Herrero

    IPC: A61K31/737 ,  A61K9/00 ,  A61P31/14 ,  A61P19/02 ,  A61P29/00

    Abstract: Disclosed is a method of treating alphavirus infections, particularly in humans, in which pentosan polysulfate is administered to an infected subject. Whilst not effecting the viral load in a subject, the pentosan polysulfate acts to reduce inflammation in tissues, such as the muscles, and in the joints of a subject. In addition, cartilage damage in the joints may be reduced. The reduction in inflammation and/or cartilage damage acts to reduce the severe pain experienced by subjects suffering from alphavirus infections, such as Ross River virus, chikungunya virus and Barmah Forest virus.

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